Ivabradine-hydrochloride - Adrenergic Receptor 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEIvabradine hydrochlorideCat. No.: HY-B0162ACAS No.: 148849-67-6分式: CHClNO分量: 505.05作靶点: Adrenergic Receptor作通路: GPCR/G Protein; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DM

2、SO : 51 mg/mL (100.98 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.9800 mL 9.9000 mL 19.8000 mL5 mM 0.3960 mL 1.9800 mL 3.9600 mL10 mM 0.1980 mL 0.9900 mL 1.9800 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Ivabradine hydroch

3、loride可服的，超极化激活的环核苷酸门控离通道 (HCN) 通道阻滞剂。体内研究Ivabradine hydrochloride treatment (10 mg/kg/d) induces long-term HRR, and that improves diastolic LVfunction probably involving attenuated hypoxia, reduced remodeling, and/or preserved nitric oxidebioavailability, resulting from processes triggered early af

4、ter HRR initiation: angiogenesis and/or preservationof endothelial nitric oxide synthase expression 1. Ivabradine hydrochloride leads to a sustained 15-20%1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEheart rate reduction, but has no effect on blood pressure. While ivabradine has no effect on end

5、othelialfunction and vascular reactive oxygen species production in angiotensin II-treated rats, it improves bothparameters in ApoE knockout mice. Ivabradine hydrochloride treatment leads to an attenuation ofangiotensin II signaling and increased the expression of telomere-stabilizing proteins in Ap

6、oE knockout mice,which may explain its beneficial effects on the vasculature. The absence of these protective ivabradineeffects in angiotensin II-infused rats may relate to the treatment duration or the presence of arterialhypertension 2.户使本产品发表的科研献 J Cell Physiol. 2019 Feb;234(2):1925-1936.See more

7、 customer validations on HYPERLINK / www.MedChemEREFERENCES1. Fang, Y., et al. Heart rate reduction induced by the if current inhibitor ivabradine improves diastolic function and attenuates cardiactissue hypoxia. J Cardiovasc Pharmacol, 2012. 59(3): p. 260-7.2. Kroller-Schon, S., et al. Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidativestress. Basic Res Cardiol, 2011. 106(6): p. 1147-58.McePdfHeightCaution: Product has not been fully validated for medical applications.For re