BEC-hydrochloride - Arginase 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBEC hydrochlorideCat. No.: HY-19548ACAS No.: 222638-67-7分式: CHBClNOS分量: 229.49作靶点: Arginase作通路: Immunology/Inflammation; Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 H2

2、O : 35 mg/mL (152.51 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 4.3575 mL 21.7874 mL 43.5749 mL5 mM 0.8715 mL 4.3575 mL 8.7150 mL10 mM 0.4357 mL 2.1787 mL 4.3575 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 BEC hydrochloride个

3、竞争性的 Arginase II抑制剂，Ki值是0.31 uM (ph 7.5)。REFERENCES1. Colleluori DM et al. Classical and slow-binding inhibitors of human type II arginase. Biochemistry. 2001 Aug 7;40(31):9356-62.1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE2. Kim NN et al. Probing erectile function: S-(2-boronoethyl)-L-cystein

4、e binds to arginase as a transition state analogue and enhancessmooth muscle relaxation in human penile corpus cavernosum. Biochemistry. 2001 Mar 6;40(9):2678-88.3. Karina Ckless et al. Inhibition of Arginase Activity Enhances Inflammation in Mice with Allergic Airway Disease, in Association withInc

5、reases in Protein S-Nitrosylation and Tyrosine Nitration. J Immunol. Author manuscript; available in PMC 2010 Jun 28.4. Steppan J et al. Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism. Proc Natl Acad Sci U SA. 2006 Mar 21;103(12):4759-64.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-