加拿大奶牛肉牛沙门氏菌

1、沙门氏菌Neonatal SalmonellosisPrepared by: Dr. Terry Hunt病因/发病机理 Cause & Pathogenesis都柏林沙门氏菌、猪伤寒沙门氏菌和其他种 Salmonella Dublin, S. typhimurium and others 内毒素造成分泌过度、吸收降低、炎症Endotoxins causing hyper secretion, decreased absorption and inflammation细胞内存活、进而全身症状，可以发展为细菌携带者 Live in cells and become systemic and ma

2、y progress to carrier state由粪便和口途径传播Transmission is by fecal/oral route 危险因素Risk Factors注意：这是人畜共患病(公众健康) This is a Zoonotic Disease (Public Health)临床症状Clinical Findings通常为产后1-2月Calves are usually 1-2 months of age发热Fever顽固性腹泻-带血或纤维粘膜Intractable diarrhea may be blood and/or fibrin脱水Dehydration虚弱Weakn

3、ess败血症Terminal septicemia 高死亡率High mortality瘦弱Emaciation 尸解和诊断 Post Mortem & Diagnosis大小肠的Pseudodiptheretic membrane in both small and large intestine 肠系膜淋巴结分离细菌Isolate organism from mesenteric lymph nodes鉴别诊断Differential Diagnosis肠杆菌病Colibacillosis轮状病毒Rotavirus冠状病毒Corona virus产气荚膜梭菌Clostridium perf

4、ringens球虫病Coccidiosis隐孢子虫病后遗症 Sequelae败血症和死亡Septicemia and death 细菌携带者Carrier state 治疗Treatment纠正脱水和酸中毒Dehydration - 皮肤皱折和眼球凹陷来确定体重%脱水比例 = 补充的液体量(L) Body weight * % dehydration = litres of fluids required Acidosis - 依据敏感性/警觉性确定 补充等渗溶液 Add to isotonic solutions 碳酸氢钠 13gm/L 13 gm of Na bicarbonate in a litre of fluid (1.3%)不能吸吮者Depressed calves that do not suckle静注液体加碳酸盐细心护理病牛 Nursing calves & mildly affected calves多次口服电解液若喂牛奶，用非碳酸盐类电解液 抗菌药 Antimicrobials 仅对细菌性腹泻有效全身使用光谱抗生素连续口服抗生素时间仅为3天预防Prevention & Control出生后2