PHCCC - mGluR Antagonist - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPHCCCCat. No.: HY-100409CAS No.: 179068-02-1分式: CHNO分量: 294.3作靶点: mGluR作通路: GPCR/G Protein; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 32 mg/mL (108.73 mM)* means sol

2、uble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.3979 mL 16.9895 mL 33.9789 mL5 mM 0.6796 mL 3.3979 mL 6.7958 mL10 mM 0.3398 mL 1.6989 mL 3.3979 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 PHCCC是Group I metabotropic glutamate receptor拮抗剂，EC50

3、是6 uM。REFERENCES1. Marino MJ et al. Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinsons diseasetreatment. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13668-73.1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE2. Maj M et al. (-)-PHCCC, a positive

4、 allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.Neuropharmacology. 2003 Dec;45(7):895-906.3. Szczurowska E et al. Positive allosteric modulator of mGluR4 PHCCC exhibits proconvulsant action in three models of epileptic seizuresin immature rats. Physiol Res

5、. 2012;61(6):619-28.4. Domin H et al. Neuroprotective potential of the group III mGlu receptor agonist ACPT-I in animal models of ischemic stroke: In vitro andin vivo studies. Neuropharmacology. 2016 Mar;102:276-94.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-589