Ondansetron-hydrochloride-dihydrate-GR-38032-hydrochloride-dihydrate-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEOndansetron hydrochloride dihydrateCat. No.: HY-B0002ACAS No.: 103639-04-9Synonyms: GR 38032 (hydrochloride dihydrate); SN 307 (hydrochloridedihydrate)分式: CHClNO分量: 365.85作靶点: 5-HT Receptor作通路: GPCR/G Protein; Neuronal Signaling

2、储存式: 4C, protect from light* 该产品在溶液状态不稳定，建议您现现配，即刻使。溶解性数据体外实验 H2O : 61.66 mg/mL (168.54 mM; Need warming)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.7334 mL 13.6668 mL 27.3336 mL5 mM 0.5467 mL 2.7334 mL 5.4667 mL10 mM 0.2733 mL 1.3667 mL 2.7334 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您

3、现现配，即刻使。BIOLOGICAL ACTIVITY物活性 Ondansetron hydrochloride dihydrate (GR 38032 hydrochloride dihydrate; SN 307 hydrochloridedihydrate)是5- HT3受体拮抗剂。户使本产品发表的科研献1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE Int J Pharm. 2015 Dec 30;496(1):33-41. Patent. US20170319486A1.See more customer validations o

4、n HYPERLINK / www.MedChemEREFERENCES1. Brown AM, et al. Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT3A). J Physiol. 1998 Mar15;507 ( Pt 3):653-65.2. Barann M, et al. Recombinant human 5-HT3A receptors in outside-out patches of HEK 293 cells: basic properties and

5、 barbiturateeffects. Naunyn Schmiedebergs Arch Pharmacol. 2000 Sep;362(3):255-65.3. Wildeboer KM, et al. Ondansetron results in improved auditory gating in DBA/2 mice through a cholinergic mechanism. Brain Res. 2009Dec 1;1300:41-50.4. Khedhaier A, et al. Circadian rhythms in toxic effects of the ser

6、otonin antagonist ondansetron in mice. Chronobiol Int. 2003Nov;20(6):1103-16.5. Umathe SN, et al. The 5-HT3 receptor antagonist, ondansetron, blocks the development and expression of ethanol-induced locomotorsensitization in mice. Behav Pharmacol. 2009 Feb;20(1):78-83.6. Doggrell SA, et al. Cardiac safety concerns for ondansetron, an antiemetic commonly used for nausea linked to cancer treatment andfollowing anaesthesia. Expert Opin Drug Saf. 2013 May;12(3):421-31.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use onl