NFAT-Inhibitor-VIVIT-peptide-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemENFAT InhibitorCat. No.: HY-P1026CAS No.: 249537-73-3Synonyms: VIVIT peptide; 11R-VIVIT分式: CHNOS分量: 1685.94Sequence: Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-GluSequence Shortening: MAGPHPVIVITGPHEE作靶点: Others作

2、通路: Others储存式: Powder -80C 2 years-20C 1 yearIn solvent -80C 6 months-20C 1 monthBIOLOGICAL ACTIVITY物活性 NFAT Inhibitor (VIVIT peptide; 11R-VIVIT)种选择性的 NFAT 抑制剂。体外研究 NFAT Inhibitor is superior at inhibiting calcineurin-mediated dephosphorylation of NFAT1, NFAT2, andNFAT4 in cell extracts. NFAT Inhibi

3、tor (100 M) that effectively inhibits NFAT1-calcineurin binding andNFAT1 dephosphorylation, does not inhibit calcineurin phosphatase activity toward the RII phosphopeptide.NFAT Inhibitor selectively inhibits NFAT activation without disrupting other calcineurin-dependent pathways1. NFAT Inhibitor att

4、enuates NFAT-dependant protein expression in immune cells. NFAT activity regulatesproinflammatory secretion and is attenuated by NFAT Inhibitor in murine microglia cultures 2.户使本产品发表的科研献 Arthritis Rheumatol. 2019 Aug;71(8):1252-1264. Sci Signal. 2018 Oct 16;11(552). pii: eaao5150.See more customer v

5、alidations on HYPERLINK / www.MedChemE1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEREFERENCES1. Aramburu J, et al. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science. 1999 Sep24;285(5436):2129-33.2. Nagamoto-Combs K, et al. Microglial phenotype is regulated by activity of the transcription factor, NFAT (nuclear factor of activated Tcells). J Neurosci. 2010 Jul 14;30(28):9641-6.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-37