AZD-0284 - RORγ Inverse Agonist - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAZD-0284Cat. No.: HY-120384CAS No.: 2101291-07-8分式: CHFNOS分量: 524.43作靶点: ROR作通路: Metabolic Enzyme/Protease储存式: 4C, stored under nitrogen* In solvent : -80C, 6 months; -20C, 1 month (stored undernitrogen)溶解性数据体外实验 DMSO : 100 mg/m

2、L (190.68 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.9068 mL 9.5342 mL 19.0683 mL5 mM 0.3814 mL 1.9068 mL 3.8137 mL10 mM 0.1907 mL 0.9534 mL 1.9068 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配

3、，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 0.83 mg/mL (1.58 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 0.83 mg/mL (1.58 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility:

4、0.83 mg/mL (1.58 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 AZD-0284核受体 ROR 的反向激动剂。 在开发于治疗寻常型斑块状银屑病和呼吸道疾病。IC50 & Target ROR 1REFERENCES1. Narjes, F, et al. The discovery of AZD0284, an inverse agonist of the nuclear receptor RORg. American Chemical Society, 2017 DrugDesign and Delivery Symposium 26 October 2017McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fa