TR-antagonist-1 - Thyroid Hormone Receptor Antagonist - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETR antagonist 1Cat. No.: HY-111443CAS No.: 500794-88-7分式: CHBrNO分量: 561.26作靶点: Thyroid Hormone Receptor作通路: Others储存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性数据体外实验 DMSO : 83.3 m

2、g/mL (148.42 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.7817 mL 8.9085 mL 17.8171 mL5 mM 0.3563 mL 1.7817 mL 3.5634 mL10 mM 0.1782 mL 0.8909 mL 1.7817 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 TR antagonist 1亲和的甲状腺激素受体 (

3、thyroid hormone receptor (TR) 拮抗剂，对 TR 和 TR 的IC50 值分别为 36 和 22 nM。IC50 & Target IC50: 36 nM (Thyroid hormone ), 22 nM (Thyroid hormone ) 1体外研究TR antagonist 1 displays high affinity for both thyroid hormone TR and TR (IC50=36 and 22 nM,respectively). TR antagonist 1 acts as a full antagonist in the T

4、RAFR cell assay and the IC50 32 nM for both1/2 Master of Small Molecules 您边的抑制剂师www.MedChemETRAF1 and TRAF1 1.体内研究 TR antagonist 1 treatment lowers heart rate and shows a possible trend toward an increase of low-densitylipoprotein cholesterol (LDL-C) in the cholesterol fed rat model 1.REFERENCES1. Koehler K, et al. Thyroid receptor ligands. 6. A high affinity direct antagonist selective for the thyroid hormone receptor. J Med Chem.2006 Nov 16;49(23):6635-7.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-589559