抗击新型冠状病毒肺炎专利信息研报

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2、ERLINK l _TOC_250003 ,人fifi 36C3 sfiy$ 36C=3 37C3 38 HYPERLINK l _TOC_250002 d,fi 40C3 40C=3 42 HYPERLINK l _TOC_250001 ,fi 44C3fi!fi PCR yflfi 44C=33 PCR yflfi 45C3fi! PCR fi 45 HYPERLINK l _TOC_250000 G,fl 47C3! 47C=3Rfl 47C3 48C3fi 48,fl, fid()9fi$ 11 , , 980 , 08 , 6, 01 , 19 , d!980$508Rfl32630

3、1192 11 (=)fififlfi$fi ,00 4AR4 01 MER4 ,“d 1 ,fi 00 4AR4,009 H1N1 01 MER401 MER4 d, , 6, 67, 80d fi, fi,“ fid 1fi,fHIT)/,d :fG)fi f HIT )f)dd 1 , RNA , RNA fi ,fifid 1 RNA ()fi呙fi$ 00 , :d 14 , ,fid fifi,fi,d 14 1 , , RNA fi d 1($)fiflfi$9fl 16 , 00019 fid 4AR4 fMER4), fid, , ,fid“, 7 fi fid 16 fi

4、17 fi, , PJR PJRRPALAMP, PJR d 17 ()$9fl , fiK fi)d, , 11d 11 ,s dw f)x, ,K, , ,fl,dfifDTPI) fJNAB4)fJNMED) CAPlus , 00 9 , d 11s,3,/ ,BJ440, fT787)RNA , 4 , J fi4 , PBMJ ,sRNA fi PDE4 vsatlidIL6/IL6R /s,fi$!yfif019nJT)fi RNA , RNA fi,K,: RNA dRNA RNA ),fi RNA f)fi, fiK 019nJT ds/d J fJlik prtinas)

5、f4 ) fAJE) d/d fi 019nJT AJE f4AR4JTHJTNL6),fMER4JT)fEbla virus) fHIT)/dfi,d()哦fl;“ ,dw f)x fi,“fiK fi 019nJT dfi 1,fid 1 fi f3 ) fJN10869771A,JN110494141A,T00190989 A1,RNA 10 T00190840 A1),fJN1077091A),fJN10911911A),fJN10844064 A),fJN10844064 A)fJN11768A),fJN178191A,JN11777A,JP0040471A,JN RNA G 1 1

6、0180900A,JN1009966A,T001180149A), fJN1076976A), fJN104848A, , T001800946A),fJN10161077A),fJN1009967,JN1047884) f3 ) f )1 fT00101177A1)fi ,3HIT1 HIT4 fJN11081960A,JN10794A, JN10746A,fi fi,JN104016A) A , fifi B fJN147777A, ) 7 JN11081960A, JN10786461A,JN1078646A),fJN11A,JN1660807A,JN10607406A)/1 fJN16

7、17A)pH 1f1)JN1077091A fi , 1 III , II6 fi(JENk fJPE), III ,d, III 3 ,d ,fi(JENk,fi )df)JN10844064A fid 1AAA JPE , 1A A JPE d1A A dfi, 1B B fifi,fi,fid 016 fi, 3d:f1)JN99809897 fi3, , A/B/J ,d 8 ffi) 100ug/l A/PR/8/4 d,fi d00 4 fi 019nJT dfi 019 8 18 ,df)JN0181067689 I , I 10ug/ML 9, 1ug/ML 100, d,fi

8、df)JN008179 I /, RNA ,R4 dfid 100ug/mLA/PR/8/ 4 100d,fi d JN10804A fi A fPR8/MDJK), 7 EJ0 fJg/l) 01,EJ90fJg/l) 08, LD0fMTT)0,LD0/ED0 00, 8EJ0fJg/l) 01,EJ90fJg/l) 07, LD0fMTT)0, LD0/ED0 00dfif),3fi :4.33 4 ,fi 33fifi,fiKd 3,fifid (1kJN011104 fi 1 /10 /fi, Tr E6 , Tr E6 , 4AR4 ;(kJN017146 10g/l 4AR4 ,

9、fi fi,;(kJN01610419 MDJK MTT, 3dfi, fi 4AR4 MER4 ,fi,fid 6 JN1617A fifi,dfi HRT16 HJQ(pg/lk JJ fi IP 10/RANTE4 d fidfid 7/ 004 fi “”fJN0048000141), fi HIT ,fi 4AR4d HIT fifid/d(=)flfififlfl;哦, BJ440 fT787)dfi III ,fi d1fRdsivir) , II d, 4AR4 MER4 d00 6 ,fi,019nJT d 11, fi011 fT001/01776A1),fidfi sd

10、fi:f 1 ) JN108486A : 4 fi 9 EJ0 046M, f Rdsivir) EJ0 08Md 44 fi f Rdsivir) HAE , 4AR4JT MER4JT EJ0 69nM 74 nMd, fif4AR4)fMER4) df)T0 018169946A1:fi Rdsivir fi, f Rdsivir ) 7 fRdsivir ),fid df) JN1070700A : f Rdsivir) HMTEJTERTHuh7 3, EB0TGFP EJ0 40nM 81 nMd 9 R EB0TGFP EJ0 6nM 70nMd Rdsivir ,fi, 019

11、nJT fid BJ440BioCryst BCX4430 ,),fi dfi RNA ,fEbola)fi fMarburg),fi I d BCX4430 13 ,fi, 2-2d BJ440 flfi!flWO 9919338A1US,fi$flflfi!flfi,fi T-fl,人fi1fl,fifip 8!/WO2012051570A1BioCrystBCX4430 $fifi RNA fi, SARS1flWO20191 40365Board of Regents of the University ofNebraskaflflfi!flWO 2013158746A1BioCrys

12、tfi!fl,fi,fi!flWO2014078778A1BioCrystfi!fl,fi,fi!flWOBioCrystfi!fl,fi,fl2014078778A1fi!flWO2014186465BioCrystfi!fl,fi,fiffiCN104513249B%BCX4430 fiffiWO2016069827A1pfi$fl BCX4430 WO2016123019A1fiflflflBCX4430 WO 2016161176The California Institute for BiomedicalResearchfl BCX4430 CN 106031731A y$fl BC

13、X4430 WO 2017076880A1Johann Wolfgang Goethe-Univer sitaet Frankfurtam Mainfiffi SAMHD1BJ440 fi :f1)JN10494BfT0010170A1):BJ440 RNA ,fi BJ440 4AR4JT ,fifi d 4AR4JT JPE EJ0 14M/l,IJ0100,4I71, EJ0 16M/l,IJ0100,4I6df)JN10479146BfT00118746A1): RNA ,), 4AR4JT JPE EJ0 14M/l,IJ0100,4I71, EJ0 16M/l,IJ0100,4I6

14、d fT787)VX-787 RNA PB2 ,I VX-787 , Vertex A , A d VX-787 17, 2-3d T787 zT0010148197 A1TrtPharautial s Inrpratd3 T787 zT00107476A1Trt Pharautial s InrpratddT787 HJl 1/H0HJl H0HJl T00107491 A1Trt Pharautials Inrpratdd T787 HJl H0 T00107481A1TrtPharautial s Inrpratd ddT00110097A fi d A T00160409 A1TrtP

15、harautial s Inrpratd A dA dT0016191079A1B0R0PHARM INJT00170974A1)dT0017104691 A1 3 dT0018008A1)T0018041091A1)T00181081A1)T001817670 A1 T787 T00181780A1)T001819147 A1TrtPharautial s Inrpratd,fi d T787 zT4AT001906A1)T00191948 A1JanssnPharautial s, InT787 fi: f1 )T0010148197A1 fi A ,fi,fi ,df)T00107491

16、A1 T787 HJl H0, fi, d A , d()fi$flfifl;哦 RNA 0 /,Biryst ,fi, fi, EMBL d0 fi, fi JT , fi, 6 fidfi J k, d fifi, dfi:1RNA f1)T0016118A , 4AR4MER4HJTNL 6d HJTNL 64AR4 MER4 fi, HJvNL6 EJ0 88uM, MER4 in Huh7 EJ0 1uM, MER4 in Tr EJ0 101uM, 4AR4 EJ0 81uMd 19 MER4 in Huh7 EJ0 uM, MER4 in Tr EJ0 4uM, 4AR4 EJ0

17、 119uMdf)T00191746A ),fid 1 fi HIT1 d 1b17b,1b HIT AD8 HIT NL4 EJ0 1 nM 64nM,17b HIT AD8 HIT NL4 EJ0 1 nM 64nMdf)JN1049094A fi, d FRET , 140 ,IJ0 011Mdf4)T0017/04618A1 , , Fp JPE fi,fi, Fp Ki 17uM, JPE IJ0 49uMdf)T0017/190A1 fi 4G , RNA ,d HEK9 3/, FIFI JJ0 fifi 100Mdf6)JN104619699 A fifi , , fifIAT

18、)d FRET (JPEk df7)T001718147A1 fi) ,fi ,d , LRA ,df8)T00107A1fJN10981A)fi), fi,d , FRET ,d 4 f1)JN00710061197 fi, 0M 4AR4 , M 4AR4 df)JN01110409179 , 4AR4 IJ0 04Mdf)JN01610479008 JN01610779 s, 4AR4 IJ0 011991Mdf4)JN0110079787 JN016101874 , M14,M18,M0 MER4JT Mpr , K/Ki ,fi N d, 4AR4MHT fid M1 1M fi 4

19、AR4JTMER4MHT d J f1)JN00100869 ffi) 4AR4 J dfi M, 1M dfi“,df)T400006764A MER4 J fi, 77 MER4 J IJ0 fi 1M, 106, 107, 109, 110, 11, 11, 116, 10, 1911,1 14 zd,fi$Thflfifi,fi ,fi ,fi RNA dK, fiRNA fid()劌哦fi fi,dfi 9 ,fi 89 ,fi, fi3fifi,fi 4 , 1d 1 fiz1/7fi664fi4 43,:1 fi/ 7 , I , ,fifid IFN 6, JN0091099

20、(sIFNak 4AR4 fl 40 d 6 ,Gs,fi3d4 4 ,fi, JN011014108 fi, , fi, d,fi , fifi,dfi) fifid: aK , 4 fifi,fifi a1b abd(=) , 4AR4JT , MER4JT10 ,fi ), )dfi 019nJT fi 4AR4JT 4 , 4AR4JT fi 019nJT fid:fi 4AR4JT, ,fi MER4JT ,fi,fi ,fi, d , d, d 6 , d fJN1866A,JN10110794A) 019nJT JR0 ,fi 4AR4JT d 1 fJN106414496A)

21、MER4JT ,fi fi 019nJT d 1 4AR4JT ,fifi 019nJT d fld zz100JN1866A4AR4JT 00JN19146A4AR4JT 004JN10110794A4AR4JT 400JN10108A4AR4JT fi008JN1001767A4AR4JT fi6014JN106414496AMER4JT ();fl哦,fi,d fififi 47 , 18 , 9 , 8 , 1 , , fi fid1 TLR7 vsatlid fJN0161100894) ET71 ,fi ,fifi, 7 fiGdJN017800687966 fi ,fi,fi,f

22、ifi,fi dJN0171111647 fi,fi,fi, fidJN01910099114 ,fi IL6 TNFa3dJN014800798 PDE4 fi,fi, )d, vsatlid PDE4 d JN0181148 JN01080061904 fi IL6 IL6 fidIL6 fi, fIL6R ),fid IL6 , IL6R fid JN01080007 JN009801810 TLRfid TLR fTA01)fi RNA fi II ,dJN0178008697 ffi ),JN016800606 fifi, JN016800606 /IL41 fi,d , IL6/I

23、L6R ,fifid, TLR /IL41 d($)RNA fi RNA 1 , d: fi RNA RNA 3, 4AR4 siRNA dfl, siRNA K ,d RNA , , d RNA zz1004JN010101194896;004JN004800416;006JN00610161044007JN007800443;008JN00880178813;6009JN0098011963;7010JN01010116048010JN010800668103;901JN01101090961001JN01800099449;11014JN01480048080;,人fifi, fi df

24、i fi 4AR4 MER4 fi d, d, 10 d()fi.呙$91 4AR4 87 ,MER4 10 HJTHKT1/NL6/ , 1 d :fi, JN106906 fi,fi 4 /d,fid/ 41 , 1 1 9 1 d ,fid:/,d,/d,d, Mdrna RNA fi fiTaart TAA4T fifidfi 4 / 49 ,fi N 11 ,fi M 4 ,fi , E lpr0RF d : 4AR4 MER4 4 /,MN /fid 4AR4 MER4 4 /, /K 4 ME ,4AR4 fi 4AR4 fifid,4 NME fifid(=)呙1 K I 4A

25、R4 JN161664f)JN166f)JN17787f) 4AR4 4AR4 sd fid JN1698 Trs B4 3,fifi 80PFT/l , 1000 Kfi , 10000 , 0407%(g/lkAl(0Hk ,/ 4AR4 , d JN1067 fi 00% ,fi d4 JN16478 fi 4AR4 G0 Tr ,fi, d()懤呙1 JN161880 fi 4AR4 , ,fifid JN17 3 N M RNA DNA 4AR4 , fi 4AR4 ,fi dJN178 3 4 RNA 4AR4 , fi, 4AR4 ,fi d JN106986 4AR4(R94F

26、1k MER4(E67T606k 4 RBD s,fifi,d,k , JN17 JN178 fi 4AR4 ,d JN16710 4AR4 4M TB 4AR4s4749aa 4AR410aa, K3fi, 3K pTA0Nf pTA1 ),fi d JN144986 4AR4 4 7bp16bp K pJDNA1(k,fi dd,fifi,019nJT d, , ,fi d,d 4, ,fifi ;fi,fi d, fi,3fid();1JN11774J 4AR4 fi,JN14877A fi 4AR4 , ,fi JN11774J,fi d d f1) 4NP JN106906A 4AR4 f4 ), 4 fi 4 ,dJN1000491J ,fi 4AR4 4NME ,fi dJP0171446A MER4 fi NP dT001906689A1 MER4 NP N J ,fi,fi MER4 dfi, ,d f) PBMJ T4104180B PBMJ , 4 fRBD), PBMJ ,dT40100700A1 fTLP) dfi: , ; ,fi d(=)懤 RTPJR , T40181786A1 fi RNA , MER4 ,K RTPJR LNA , dT4019080A1 fi, as