S-Flurbiprofen-Esflurbiprofen-DataSheet-生命科学试剂-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemE(S)-FlurbiprofenCat.No.:HY-15123CASNo.:51543-39-6Synonyms:Esflurbiprofen分⼦式:C₁₅H₁₃FO₂分⼦量:244.26作⽤靶点:COX;PGEsynthase作⽤通路:Immunology/Inflammation储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:100mg/mL(409.40mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM4.0940mL20.4700mL40.9400mL5mM0.8188mL4.0940mL8.1880mL10mM0.4094mL2.0470mL4.0940mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的⼯作液，建议您现⽤现配，当天使⽤；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分⽐指该溶剂在您配制终溶液中的体积占⽐)：1.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(10.23mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(10.23mM);Clearsolution1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性(S)-FlurbiprofenFlurbiprofen的活性对映体，其对COX-1和COX-2的IC50分别为0.48μM和0.47μM。IC50&TargetCOX-1COX-20.48μM(IC50)0.47μM(IC50)体外研究(S)-Flurbiprofen(10–7M)resultsinatotalsuppressionofbasalandstimulatedPGE2releaseinratskin[2].REFERENCES[1].ACarabaza,etal.StereoselectiveInhibitionofInducibleCyclooxygenasebyChiralNonsteroidalAntiinflammatoryDrugs.JClinPharmacol.1996Jun;36(6):505-12.[2].BAverbeck,etal.InflammatoryMediatorsDoNotStimulateCGRPReleaseifProstaglandinSynthesisIsBlockedbyS(+)-flurbiprofeninIsolatedRatSkin.InflammRes.2003Dec;52(12):519-23.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-