Acetylene-linker-Val-Cit-PABC-MMAE-LCB14-0602-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAcetylene-linker-Val-Cit-PABC-MMAECat.No.:HY-19812CASNo.:1411977-95-1Synonyms:LCB14-0602分⼦式:C₆₇H₁₀₆N₁₀O₁₆分⼦量:1307.62作⽤靶点:Drug-LinkerConjugatesforADC作⽤通路:Antibody-drugConjugate/ADCRelated储存⽅式:4°C,storedundernitrogen*该产品在溶液状态不稳定，建议您现⽤现配，即刻使⽤。溶解性数据体外实验DMSO:50mg/mL(38.24mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM0.7647mL3.8237mL7.6475mL5mM0.1529mL0.7647mL1.5295mL10mM0.0765mL0.3824mL0.7647mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现⽤现配，即刻使⽤.体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥1.25mg/mL(0.96mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥1.25mg/mL(0.96mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥1.25mg/mL(0.96mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性Acetylene-linker-Val-Cit-PABC-MMAE(LCB14-0602)由ADClinker(Acetylene-linker-Val-Cit-PABC)和MMAE组成，MMAE⼀种有效的微管(tubulin)抑制剂。Acetylene-linker-Val-Cit-PABC-MMAE(LCB14-0602)可⽤于偶联抗体。IC50&TargetAuristatinREFERENCES[1].PROTEIN-ACTIVEAGENTCONJUGATESANDMETHODFORPREPARINGTHESAME.WIPOPatentApplicationWO/2012/153193.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>