O-304-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEO-304Cat.No.:HY-112233CASNo.:1261289-04-6分⼦式:C₁₆H₁₁Cl₂N₃O₂S分⼦量:380.25作⽤靶点:AMPK作⽤通路:Epigenetics;PI3K/Akt/mTOR储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:30mg/mL(78.90mM;Needultrasonicandwarming)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.6298mL13.1492mL26.2985mL5mM0.5260mL2.6298mL5.2597mL10mM0.2630mL1.3149mL2.6298mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(6.57mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性O-304⼀种⾸创的，具有⼝服活性的泛AMPK激活剂，可通过抑制pAMPK的去磷酸化来增加AMPK活性。O-304可⽤于2型糖尿病和相关⼼⾎管并发症的研究。IC50&TargetAMPK[1]体内研究O-304increasesglucoseuptakeinskeletalmuscle,reducedβcellstress,andpromotedβcellrestindiet-inducedobesemice.O-304reducesfastingplasmaglucoselevelsandhomeostasismodelassessmentofinsulinresistance(HOMA-IR)inaproof-of-conceptphaseIIaclinicaltrialintype2diabetes(T2D)patientsonMetformin[2].户使⽤本产品发表的科研⽂献•BiochemJ.2022Jun7;BCJ20220170.•BiochemJ.2021Oct20;BCJ20210411.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].PeriodicReportingforperiod1-AMPK-DIAB(AsmallmoleculeAMPactivatedproteinkinase(AMPK)activator,denotedO304,asanovelinnovativedrugforthetreatmentoftype2diabetes).McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792