Z-Lanoconazole-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE(Z)-LanoconazoleCat.No.:HY-14282A分⼦式:C₁₄H₁₀ClN₃S₂分⼦量:319.83作⽤靶点:Fungal作⽤通路:Anti-infection储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:100mg/mL(312.67mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM3.1267mL15.6333mL31.2666mL5mM0.6253mL3.1267mL6.2533mL10mM0.3127mL1.5633mL3.1267mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(7.82mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:2.5mg/mL(7.82mM);Suspendedsolution;Needultrasonic1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性(Z)-LanoconazoleLanoconazole的Z构型形式。Lanoconazole⼀种强效⼝服咪唑类抗真(antifungal)试剂，具有⼴谱的体内外抗真活性。Lanoconazole通过抑制sterol14-alpha去甲酶，阻断真膜上的ergosterol⽣物合成，从⽽⼲扰ergosterol的⽣物合成。Lanoconazole可⽤于⽪肤真病和甲真病的研究。IC50&TargetIC50:antifungal[1]体内研究ressthleprtriotfoneuror;phhe-3motctictorsossuts,

inflammatoryprotein-2,andinhibitedneutrophilinfiltrationtotheinflammationsite[2].Lanoconazole(oral

administration;3,10or30mg/kg;onceaday;3weeks)significantlyinhibitsC.neoformanscomparedwiththesaline

controlinnormalmice.Inaddtion,itsignificantlyreducesthegrowthofC.neoformansinthelungsandbrainsof

MAIDSmice[3].REFERENCES[1].ShokoohiGR,etal.InVitroActivitiesofLuliconazole,Lanoconazole,andEfinaconazoleComparedwithThoseofFiveAntifungalDrugsagainstMelanizedFungiandRelatives.AntimicrobAgentsChemother.2017Oct24;61(11).pii:e00635-17.[2].NakamuraA,etal.Anti-inflammatoryeffectoflanoconazoleon12-O-tetradecanoylphorbol-13-acetate-and2,4,6-trinitrophenylchloride-inducedskininflammationinmice.Mycoses.2020Feb;63(2):189-196.[3].FurukawaK,etal.Lanoconazole,anewimidazoleantimycoticcompound,protectsMAIDSmiceagainstencephalitiscausedbyCryptococcusneoformans.JAntimicrobChemother.2000Sep;46(3):443-50.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forres