分子检测与男性生殖病理

伴滋养层分化

上皮增 变模扁平 状内翻

3

4FISH检测：3,7和 左图：低级别内翻生长型UC17 （蓝色信号）扩右图：低级别内翻生长型UC3号 5实验结果-FISH

实验结果-FISHUroVysionFISH在内翻生长型UC中24/38(63.2%)病例阳性，内翻性 的内翻生长型UC中有9/13(69.2%)UroVysion UroVysion6

2004

2016

透明细胞RCC状RCC未分类的RCC透明细胞透明细胞 状RCC嫌色细胞(经典型)RCCMiTF-TFE(易位)RCC未分类7 状结构的肾肿状RCC(1型和2型) 状RCC 遗传性平滑肌瘤病肾细胞癌综合征相关的RCC

ClearcellrenalcellcarcinomaMostcommon(70-Lossofchromosome3p(60-HarboringabnormalitiesoftheVHLgene3pPapillaryrenalcellcarcinomaMostcommonnon-clearcellsubtype(10-Trisomyofchromosome7and/or17，lossofchromosomeY(Male)ActivationofMET

Metastaticrenalcell20-30%ofpatientswithmetastaticRCCatthetimeofdiagnosisAnother30%subsequentlydevelopmetastasisafterresectionHistologicsubty ofmetastaticRCCcanbeparticularlyproblematic8FDual-colorfluorescenceinsituhybridization3pdeletion Disomy7/17Fsupportingtheclassificationof9MetastaticclearcellrenalcellDual-colorfluorescenceinsituhybridizationLackof3pdeletion Trisomy7/17supportingthereclassificationof 分子检测 肿瘤病

•导

☞ ☞两类上皮（分泌细胞、基底细胞☞ ☞产物异常： (Ck5/6,(Ck5/6,p63,34βE12,TMPRSS2:ERGGeneFusionisSpecificforProstate

OriginofProstaticSmallCellCarcinomatherapyorfromselectiveoutgrowthofrareclonalpopulationsduringhormonaltherapycopynumberchange?ARamplification:>10%ofthenucleicontainedmultiplesignalsandtheARsignal/Xp11signalratiowasPolysomy:>10%ofthenucleicontainedgreaterthantwosignalsofARandtheAR/Xp11ratiowas<2consideredtobeFISHpositive

ERG

状腺瘤（无） 状肾细胞癌（7/17三体，Y缺失后肾腺瘤（无）&实体型 状肾细胞癌（7/17三体，Y缺失）&肾母细胞嗜 瘤（无）&嫌色细胞癌（嗜酸性）（1,2,6,10,17丢失透明细胞肾细胞癌（3p，VHL） 状肾细胞癌（7/17三体，Y缺失&TFE3易位肾癌（TFE3融 ）&透明细 状肾细胞癌（无状肾细胞癌（7/17三体，Y缺失）&粘液样小管状和梭形细胞癌（无内翻 上皮癌（3,7,和17多体，9p21缺失）&内翻 状瘤（无Xp11.2①t(X;1)(p11.2;q21)，PRCC-②t(X;17)(p11.2;q25)，ASPL-③t(X;1)(p11.2;p