药学英语之减肥药原理讲解

GenericName:Sibutraminehydrochloride

ProductName:Reductil/EctivaProductname:QuMeiGenericName:

Sibutraminehydrochloride

SibutramineFormula:

C17H26ClN

molecule

ChemicalstructureIndications:

obesity(肥胖症，多脂)！！！

pharmacologySibutramineisaneurotransmitter(神经递质)reuptake（重吸收）inhibitorthatreducesthereuptakeofserotonin（血清素),norepinephrine（去甲肾上腺素）,anddopamine,therebyincreasingthelevelsofthesesubstancesinsynapticclefts（突触间隙）andhelpingenhancesatiety（饱满感）;theserotonergic（5-羟色胺能）action,inparticular,isthoughttoinfluenceappetite.

contraindicationsSibutramineiscontraindicatedin:1Psychiatric(精神病学旳)conditionsasbulimianervosa（神经性贪食症）,anorexia（厌食症）,seriousdepressionorpreexistingmania（狂躁症）2Patientsbelow18yearsofage3Concomitant（伴行旳，并发旳）treatmentwithaMAOinhibitor（单胺氧化酶克制剂）,antidepressantorothercentrallyactivedrugs,particularlyotheranoretics（消瘦剂，减食欲剂）4Hypertensionthatisnotsufficientlycontrolled(cautionincontrolledhypertension)5Existingpulmonaryhypertension（肺动脉高血压）6Pregnantandlactating（泌乳）women

sideeffects!!Frequentlyencounteredsideeffectsare:drymouth,paradoxicallyincreasedappetite,nausea(恶心),strangetasteinthemouth,upsetstomach,constipation（便秘）,troublesleeping,dizziness,drowsiness（困倦）,menstrualcramps/pain,headache,flushing（面红）,orjoint/musclepain.Thefollowingsideeffectsareinfrequentbutseriousandrequireimmediatemedicalattention:

cardiacarrhythmias（心律不齐）,paresthesia（感觉异常）,mental/moodchanges(e.g.,excitement,restlessness,confusion,depression,rarethoughtsofsuicide).Symptomsthatrequireurgentmedicalattentionare

seizures（癫痫发作）,problemsurinating（排尿）,abnormalbruising（碰伤）orbleeding,hematemesis（呕血）,feverandrigors（僵直）,chestpain,hemiplegia,（半身不遂）abnormalvision,dyspnea（呼吸困难）andedema.（水肿）Suggestion!!Don’ttakeQUMeioranykindofmedicinewhosemainingredientisSibutramine.Moreexerciseandlessfoodi