原发性高血压患者静息心率与高敏C反应蛋白、内皮素、靶器官损害的研究的论文

原发性高血压患者静息心率与高敏C反应蛋白、内皮素、靶器官损害的研究的论文 原发性高血压患者静息心率与高敏C反应蛋白、内皮素、靶器官损害的研究的论文AbstractObjective:Toinvestigatetherelationshipbetweenrestingheartrate(RHR)andhigh-sensitivityC-reactiveprotein(hs-CRP),endothelin(ET),andtargetorgandamageinpatientswithprimaryhypertension.Methods:Atotalof168patientswithprimaryhypertensionwereenrolledinthiscross-sectionalstudy.RHRwasmeasuredbyelectrocardiogram,andhs-CRPandETweremeasuredbyenzyme-linkedimmunosorbentassay.Targetorgandamagewasassessedbyechocardiography,carotidintima-mediathickness,andestimatedglomerularfiltrationrate.Results:ThemeanRHRwas72.5±9.8beats/min,andthemeanhs-CRPandETlevelswere3.8±3.7mg/Land3.1±1.8pg/mL,respectively.RHRwaspositivelycorrelatedwithhs-CRP(r=0.309,P<0.001)andET(r=0.283,P<0.001).Afteradjustingforpotentialconfoundingfactors,RHRremainedindependentlyassociatedwithhs-CRP(β=0.239,P=0.002)andET(β=0.176,P=0.027).Furthermore,RHRwaspositivelycorrelatedwithleftventricularmassindex(r=0.277,P<0.001)andcarotidintima-mediathickness(r=0.245,P=0.002),butnotwithestimatedglomerularfiltrationrate.Conclusion:RHRispositivelycorrelatedwithhs-CRP,ET,leftventricularmassindex,andcarotidintima-mediathicknessinpatientswithprimaryhypertension.ThesefindingssuggestthatRHRmaybeausefulmarkerforidentifyingpatientswithhypertensionwhoareatincreasedriskoftargetorgandamage.Keywords:restingheartrate,high-sensitivityC-reactiveprotein,endothelin,targetorgandamage,hypertension摘要目的：探讨静息心率（RHR）与高敏C反应蛋白（hs-CRP）、内皮素（ET）及靶器官损害在原发性高血压患者中的关系。方法：本横断面研究纳入168例原发性高血压患者。使用心电图测量RHR，采用酶联免疫吸附法测量hs-CRP和ET。采用超声心动图、颈动脉内膜-中膜厚度和估测肾小球滤过率评估靶器官损害。结果：平均RHR为72.5±9.8次/分钟，平均hs-CRP和ET水平分别为3.8±3.7mg/L和3.1±1.8pg/mL。RHR与hs-CRP（r=0.309，P<0.001）和ET（r=0.283，P<0.001）呈正相关。在调整潜在混杂因素后，RHR仍独立与hs-CRP（β=0.239，P=0.002）和ET（β=0.176，P=0.027）相关。此外，RHR与左心室质量指数（r=0.277，P<0.001）和颈动脉内膜-中膜厚度（r=0.245，P=0.002）呈正相关，但与估测肾小球滤过率无相关性。