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2Risks
Of
Investing
In
InnovationPleasenote:CompaniesthatARKbelievesarecapitalizingondisruptiveinnovationanddevelopingtechnologiestodisplaceoldertechnologiesorcreatenewmarketsmaynotinfact
do
so.ARKaimstoeducateinvestorsandseekstosizethepotentialinvestmentopportunity,
notingthatrisksanduncertaintiesmayimpact
our
projectionsandresearchmodels.Investorsshouldusethecontentpresentedfor
informationalpurposesonly,
andbeawareofmarket
risk,disruptiveinnovationrisk,regulatoryrisk,andrisksrelatedtocertaininnovationareas.Pleasereadriskdisclosurecarefully.RISK
OFINVESTING
IN
INNOVATIONRAPIDPACEOFCHANGEREGULATORYHURDLESPOLITICALORLEGALPRESSURECOMPETITIVELANDSCAPEDISRUPTIVEEXPOSUREACROSSSECTORSANDMARKETCAPINNOVATIONUNCERTAINTYANDUNKNOWNSàAim
for
a
cross-sector
understanding
of
technologyandcombinetop-down
and
bottom-up
research.àAim
to
understand
theregulatory,
market,
sector,andcompany
risks.
(See
Disclosure
Page)Sources:ARKInvestmentManagementLLC,2023.3BigIdeas
2024DisruptingTheNorm,DefiningTheFutureARKInvest
proudlypresents"BigIdeas2024:DisruptingtheNorm,DefiningtheFuture."
Atraditionsince2017,BigIdeasoffersacomprehensiveanalysisof
technological
convergenceand
itspotentialtorevolutionizeindustriesandeconomies.ARKseekstodeliver
long-termcapitalappreciationbyinvestingintheleaders,enablers,and
beneficiariesofdisruptiveinnovation.With
abelief
thatinnovationiskey
notonly
togrowthbut
alsotoresilience,ARKemphasizesthenecessityof
astrategicallocationto
innovationinevery
investor'sportfolio.Thisapproachaimstotapintotheexponentialgrowthopportunitiesoftenoverlooked
inbroad-based
indices,whilesimultaneouslyprovidingahedgeagainst
therisksposed
byincumbentsfacingdisruption.We
hopeyou
enjoyBigIdeas2024.54TechnologicalConvergenceArtificialIntelligenceBitcoinAllocationBitcoin
In
202319344353SmartContractsDigitalConsumersDigital
Walle
ts647587Precision
TherapiesMultiomic
To
ols
&
TechnologyElectric
VehiclesRobotics96104113122Robotaxis133AutonomousLogisticsReusable
Rockets3D
Printing1431535ResearchBy:BrettWintonChiefFuturistARKVentureInvestmentCommitteeMemberTechnologic
alConver
ge
nceSources:ARKInvestmentManagementLLC,2024.Forecastsareinherentlylimitedandcannotbereliedupon.Forinformationalpurposesonlyandshouldnotbeconsideredinvestmentadviceorarecommendationtobuy,sell,orholdanyparticularsecurity.Pastperformanceisnotindicativeoffutureresults.6According
to
ARK’sresearch,
convergence
among
disruptive
technologies
will
define
this
decade.Five
major
technology
platforms—Artificial
Intelligence,
Public
Blockchains,
Multiomic
Sequencing,Energy
Storage,
and
Robotics—are
coalescing
and
should
transform
global
economic
activity.Technological
convergence
could
create
tectonic
macroeconomicshifts
more
impactful
than
thefirst
and
second
industrial
revolutions.Globally,
real
economic
growth
could
accelerate
from
3%on
average
during
the
past
125
years
to
more
than
7%during
the
next
7
years
as
robots
reinvigoratemanufacturing,
robotaxistransform
transportation,
and
artificial
intelligence
amplifiesknowledgeworker
productivity.Catalyzed
by
breakthroughs
in
artificial
intelligence,the
global
equitymarket
value
associatedwith
disruptive
innovation
could
increase
from
16%
of
the
total*
to
more
than
60%
by
2030.
As
aresult,
the
annualized
equity
return
associated
with
disruptive
innovation
could
exceed
40%during
the
nextseven
years,
increasingits
market
capitalization
from
~$19
trillion
today
to
roughly$220trillion
by
2030.*Throughoutthissection,weincludepublicblockchainvalueaspartofallcalculationsandforecastsof“equitymarketvalue.”Sources:ARKInvestmentManagementLLC,2024.ThisARKanalysisisbasedonarangeofunderlyingdatafromexternalsources,whichmaybeprovideduponrequest.Forecastsareinherentlylimitedandcannotbereliedupon.Forinformationalpurposesonlyandshouldnotbeconsideredinvestmentadviceorarecommendationtobuy,sell,orholdanyparticularsecurity.Pastperformanceisnotindicativeoffutureresults.7PublicBlockchainsUponlarge-scaleadoption,allmoneyandcontractslikelywillmigrateontoPublicBlockchainsthatenable
andverify
digitalscarcity
andproofofownership.ThefinancialecosystemislikelytoreconfiguretoaccommodatetheriseofMultiomicSequencingCryptocurrencies
andSmartContracts.Thesetechnologiesincreasetransparency,reducetheinfluenceofcapitalandregulatorycontrols,andcollapsecontractexecutioncosts.Insuchaworld,DigitalWalletswouldbecomeincreasinglynecessaryasmoreassetsbecomemoney-like,andcorporationsandconsumersadapttothenewfinancialinfrastructure.Corporatestructuresthemselvesmaybecalledintoquestion.Thecosttogather,sequence,andunderstanddigitalbiologicaldataisfallingprecipitously.MplualttfioormmiscwT
eitchhunnoplorgeiceesdpernotveidd
ea
cr
ec
es
es
sa
rtcohD
N
A
,scientists,therapeuticorganizationsandhealthFive
InnovationPlatforms
AreConvergingAndDefining
ThisRMNuAl
t,i
opmr
oitcedi
na,
taansdh
odui
gl
idt
aflehe
edailnt
ht
odnaot
av
.eCl
aPnrecceirs
icoanreshouldtransformwithpan-cancerbloodtests.ArtificialIntelligenceTcohnerdai
tpiioenss
u.
Ms
i
nugl
t
ieommei
rcgsi
ns
hg
oguelndeuendl
oi
tci
nk
ge
tnetci
rhenl
yi
qnueewsComputationalsystemsandsoftwarethatevolvewithdatacansolveintractableproblems,automateknowledgework,andacceleratetechnology’sintegrationintoeveryeconomicsector.Theadoptionof
NeuralNetworksshouldprovemoremomentousthantheintroductionoftheinternetandpotentiallycreate10softrilliondollarsofvalue.Atscalethesesystemswillrequireunprecedentedcomputationalresources,andAI-specificcomputehardwareshoulddominatetheNextGenClouddatacentersthattrainandoperateAImodels.Thepotentialforend-usersisclear:aconstellationofAI-drivenIntelligentDevicesthatpervadepeople'slives,changingthewaythattheyspend,work,andplay.Theadoptionofartificialintelligenceshouldtransformeverysector,impacteverybusiness,andcatalyzeeveryinnovationplatform.thattargetandcurerarediseasesandchronicPcorongsrtarumcmtsawbiltehBaipoplol
igcya
tciaopnas
baicl
irtoi
es
ss
,
iinndcul
usdt
riinegs
,
t
hedesignandsynthesisofnovelbiologicalparticularlyagricultureandfoodproduction.Technological
EraRoboticsEnergy
StorageCatalyzedbyartificialintelligence,AdaptiveRobots
canDecliningcostsof
AdvancedBatteryTechnology
shouldcauseanexplosionin
formfactors,enabling
AutonomousMobilityoperatealongsidehumansandnavigatelegacyinfrastructure,changingthewayproductsaremadeandsold.3DPrintingshouldcontributetothedigitizationofmanufacturing,increasingnotonlytheperformanceandprecisionofend-usepartsbutalsotheresilienceofsupplychains.Meanwhile,theworld’sfastestrobots,ReusableRockets,shouldcontinuetoreducethecostoflaunchingsatelliteconstellationsandenableuninterruptibleconnectivity.Anascentinnovationplatform,roboticscouldcollapsethecostofdistancewithhypersonictravel,thecostofmanufacturingcomplexitywith3Dprinters,andthecostofproductionwithAI-guidedrobots.systemsthatcollapsethecostofgettingpeopleandthingsfromplacetoplace.Electricdrivetraincostdeclinesshouldunlockmicro-mobilityandaerialsystems,includingflyingtaxis,enablingbusinessmodelsthattransformthelandscapeofcities.Autonomyshouldreducethecostoftaxi,delivery,andsurveillancebyanorderofmagnitude,enablingfrictionlesstransportthatcouldincreasethevelocityofe-commerceandmakeindividualcarownershiptheexceptionratherthantherule.Theseinnovationscombinedwithlarge-scalestationarybatteriesshouldcauseatransformationinenergy,substitutingelectricityforliquidfuelandpushinggenerationinfrastructuretowardstheedgeofthenetwork.Sources:ARKInvestmentManagementLLC,2024.ThisARKanalysisisbasedonarangeofunderlyingdatafromexternalsources,
whichmaybeprovideduponrequest.Forecastsareinherentlylimitedandcannotbereliedupon.Forinformationalpurposesonlyandshouldnotbeconsideredinvestmentadviceorarecommendationtobuy,sell,orholdanyparticularsecurity.Pastperformanceisnotindicativeoffutureresults.8ConvergingTechnologies
Are
GeneratingAHistoric
Technological
WaveEstimatedEconomicImpactofGeneralPurposeTechnologies(AnnualPercentagePointAdditionstoRealGDPGrowthAndConsumerSurplus)183DPrintingReusableRocketsAdaptiverobotsAdvancedBatteriesAutonomousMobilityCloudComputingInternal
Combustion
EngineElectricity138InternetCellphonesGPSTelephoneRadioRefrigerationAirConditioningAITheWebChemicals&SyntheticPCsBiotechFiberopticsE-CommerceRenewablesMaterialsAutomobileAssemblyLineTelevisionRailroadsTelegraphIntelligentDevicesMultiomicTechnologyPrecisionTherapiesProgrammableBiologyDigitalWalletsSmartContractsCryptocurrenciesIntegrated
CircuitPhotographyBicycleJetEngineNuclearPowerSteamEngineContainerization3-2Sources:ARKInvestmentManagementLLC,2024.ThisARKanalysisisbasedonarangeofunderlyingsources,includingBekaret
al.2017,whichmaybeprovideduponrequest.ThechartusesGPT4promptingtosurveyacomprehensivelistofgeneralpurposetechnologiesusingtheidentificationframeworkdetailedtherein.Whereavailable,academic
literatureisalsousedtoassessattributableeconomicimpact.AGPT-4
scoringrubricassessestechnology-by-technologyimpacts.Theimpactmeasureddirectlyismatchedagainstthescoringtotuneallscorestoproducetechnology-by-technologyestimatesofeconomicimpact(evenwhendirectmeasuresofeconomicimpactareunattainable).ConsistentwithGeneralPurposeTechnologytheory,thesetechnologiesareassumedtogo
throughaperiodofinvestmentinwhicheconomicimpactisnegativebeforeproductivityadvancesbegintorealizeintoeconomicdata.
Alltechnologiesareassumedtohavethesamediffusionandrealizationcycle.Ifrecenttechnologiesareassumedtodiffuse
morequickly,thecurrentwavewouldappearsteeper.Forecastsareinherentlylimitedandcannotbereliedupon.Forinformationalpurposesonlyandshouldnotbeconsideredinvestmentadviceorarecommendationtobuy,sell,orholdanyparticularsecurity.Pastperformanceisnotindicativeoffutureresults.AI
ServesAs
The
CentralTechnology
CatalystTheTechnology
Convergencematrixillustratestherelationshipsbetweenandamongtechnologies.Cryptocurrencies9Convergence
ScoreSmartContractsHighestDigitalWalletsPrecisionTherapiesHighMidMultiomicTechnologyProgrammableBiologyNeuralNetworksNextGenCloudIntelligentDevicesLowAutonomousMobilityAdvancedBatteryTechnologyLowestRenewableRocketsAdaptiveRobotics3DPrintingAdvancedCrypto-currenciesSmartContractsDigitalWalletsPrecisionTherapiesMultiomic
ProgrammableTechnology
BiologyNeuralNetworksNextGenCloudIntelligentDevicesAutonomousMobilityRenewableRocketsAdaptiveRobotics3DPrintingBatteryTechnologyCatalyzing
TechnologyMoredetailedversionofthisgraphic,includingdetailedscoringinformationandjustificationavailable
here.Sources:ARKInvestmentManagementLLC,2024.ThisARKanalysisisbasedonarangeofunderlyingdatafromexternalsources,whichmaybeprovideduponrequest.Forecastsareinherentlylimitedandcannotbereliedupon.Forinformationalpurposesonlyandshouldnotbeconsideredinvestmentadviceorarecommendationtobuy,sell,orholdanyparticularsecurity.Pastperformanceisnotindicativeoffutureresults.10AI
Is
Accelerating
Faster
Than
ForecastersAnticipatedExpected
Years
Until
LaunchOfAGeneralArtificialIntelligenceSystem(LogScale)PreGPT-3average80years100101OpenAIannouncesGPT-3Googledemonstratesadvancedconversationalagent,LLaMda250yearsChatGPTlaunchestothepublic34yearsGPT-4launches18years8years2019202020212022202320242025202620272028202920
30Sources:ARKInvestmentManagementLLC,2024,basedondatafromMetaculus,includingbenchmarkdetails,asofJanuary3,2024.
Benchmarkbroadlyrequiresthesuccessfulpassageofanadversarialtwo-hourTuningtest,broadsuccessonaQ&Aknowledgeandlogicbenchmark,andthesuccessfulinterpretationofandexecutioncomplexmodelcarassembly
instruction,allwithinasinglesystem.GreenlinesarederivedestimatesfortimetogeneralpurposeAI(stronglyformulated)baseduponforecastsforaweakerbenchmark.Forecastsareinherentlylimitedandcannotbe
reliedupon.Forinformationalpurposesonlyandshouldnotbeconsideredinvestmentadviceorarecommendationtobuy,sell,orholdanyparticularsecurity.Pastperformanceisnotindicativeoffutureresults.11IndividualTechnology
Advances
Can
Coalesce
AndCascadeIntoMassiveNew
MarketOpportunitiesNeuralNetworksAdvanced
Battery
TechnologyAutonomousMobility+=AdvancedAIenablesrobotaxistorely
onfewer,
lessexpensivesensors.Batteryelectricdrivetrainsreducerobotaxioperatingcostsby60%.ThecombinationofAIandbatteryelectricdrivetrainsenablesrobotaxisystemstoscale.RobotaxiManufacturingCosts(PerVehicle,
2024)*RobotaxiOperatingCostPerMileByDrivetrainTypeAdaptive
Robotics200$0.31InadditiontobetterbatteriesandAI,general
purposerobotswillrequirebetter:15010050•
Electricmotors$0.12•
Power
electronics•
Sensors•
Power-efficient
computeAsrobotaxisscale,thecostofeachtechnologyshoulddeclineaccordingtoitslearningcurve.WaymoTesla9CamerasInternal
combustionElectric5LIDARs,29cameras,6radars,8ultrasonicsensors*Waymomanufacturingcostsareestimatedbaseduponpublicstatements.Sources:ARKInvestmentManagementLLC,2024.ThisARK
analysisisbasedonarangeofexternalsources,whichmaybeprovideduponrequest.Forecastsareinherentlylimitedandcannotbereliedupon.Forinformationalpurposesonlyandshouldnotbeconsideredinvestmentadviceorarecommendationtobuy,sell,orholdanyparticularsecurity.Pastperformanceisnotindicativeoffutureresults.12The
ImpactOf
These
Technologies
On
The
Economy
ShouldProve
DramaticEconomicImpactofSelectMajorTechnologies(CumulativeIncreaseInRealGDPAttributabletoTechnologyAfterIntroduction)140%12
0%100%80%60%40%20%0%**Information
Technology(1995
to2005)Auto
nomou
sMobility(2023
to
2030)SteamEngine(1830to1910)AI(2023
to
2030)IndustrialRobots(1997to2007)AdaptiveRobotics*(2023to2030)*AdaptiveRobotics,AutonomousMobility,andAIImpactareARKInvestestimates.AIestimateincludesconsumersurplusesthat
maynotbecapturedintraditionaleconomicstatistics.IT
productivityimpactlikelyalsoundercountsconsumersurplus.IndustrialRobotandIT
impactmeasuresimpactonUS,Europe,andJapaneseeconomies.SteamEngineimpactismeasuredagainsttheUKeconomy.
Sources:ARKInvestmentManagementLLC,2024,basedondatafromCrafts2004,O’Mahonyetal.2009,and
McKinseyGlobalInstitute
2017.
Forecastsareinherentlylimitedandcannotbereliedupon.Forinformationalpurposesonlyandshouldnotbeconsideredinvestmentadviceorarecommendationtobuy,sell,orholdanyparticularsecurity.Pastperformanceisnotindicativeoffutureresults.13Technological
Innovation
Could
Be
Disruptive
Enough
To
Dominate
GlobalEquity
MarketCapitalizations20232030AnnualGrowthForecastEquity
MarketCapEstimateEquity
MarketCapForecastNon-innovationDisruptiveInnovationTotal$98
trillion$19
trillion$117
trillionNon-innovationDisruptiveInnovationTotal$140trillion$220
trillion$360
trillion3%42%17%MultiomicSequencingArtificiaI
IntelligenceRobotics37%PublicBlockchainsEnergyStorage50%PublicBlockchains48%RoboticsEnergyStorage78%Multiomic
Sequencing39%AINote:Forecastednumbersarerounded.Sources:ARKInvestmentManagementLLC,2024.ThisARKanalysisisbasedonarangeofexternalsources,includingtheWorldFederationofExchangesandtheMSCIACWIIMIInnovationIndexwhichmaybeprovideduponrequest.Forecastsareinherentlylimitedandcannotbereliedupon.Forinformationalpurposesonlyandshouldnotbeconsideredinvestmentadviceorarecommendationtobuy,sell,orholdanyparticularsecurity.Pastperformanceisnotindicativeoffutureresults.ExpectationsFor
Public
Blockchains14Althoughthe
scenariosdescribed
inthe
table
beloware
writteninpresent
tense,
they
are
forecasted,
possible
outcomesbasedonARK'sviews.
These
possible
outcomesmay
not
be
realized
inthefuture
due
to
a
number
of
uncertainties.
The
informationprovided
should
not
be
considered
investment
advice
and
should
not
form
the
basisof
any
investment
decision.Technology2040PossibilitiesARK’s2030Expectationof
ProgressCryptocurrencieshavedisplacedmostpermission-based,centrallycontrolledmonetarysystems,enablingfinancialecosystemstoreformulatearoundadigitalassetthatcan
eliminatecounterpartyriskwhilecontinuingtofacilitatetransactionflows.Thereformulationbeganattheedgesofthetraditionalfinancialsystemingeographieswithbrokenmoneysystemsandinmarketsotherwisemis-servedbytraditionalfinancialintermediaries.Indevelopedmarkets,cryptocurrenciesinitiallyservedasastoreofvalue,providinglittledirectutility.Overtime,theefficienciesofatrulyneutraldigitalcurrency,primarilybitcoin,haveprevailedoverotherfinancialarchitectures.GlobalmoneysupplyhasgrownintandemwithGDP,andcryptocurrenciesnowaccountfor~10%ofthetotal.Littleofthatvalueaccrualisattributabletothedirectdisplacementofmoneythoughthereareinstancesinemergingmarkets.Muchoftheappreciationisafunctionoflowsingle-digitpercentallocationsbyinstitutionalandhighnetworthindividualsaswellascorporateandnation-statetreasuries.Cryptocurrenciescontinuetodisplacegoldasaflight-to-safetyasset,taking40%shareofthemarket.Utilityusecasessuchasremittancesandglobalsettlementsaccountfor~10%and~5%ofvolumes,respectivelyCryptocurrenciesMostcontractshavemigratedtoopen-sourceprotocolsthatenable
andverifydigitalscarcityandproofofownership.Risk-sharingarrangementsaremoretransparent,assetsofallsortsaresecuritized,bought,andsoldmoreeasily,andcounterpartyriskshavediminishedsubstantially.Theimportanceoftraditionalfinancialintermediarieshasdwindled,evenasmorehumanactivitybecomescommercialized.Decentralizedprotocols,enabledbybalance-sheet-lightdigitalwalletplatforms,facilitatemosttraditionalfinancialfunctions.Consumerinternetservicesrelyonbusinessmodelsenabledbydigitalassetownership.Everycorporateentityandeveryconsumerhasadaptedascentralizedcorporatestructuresthemselvesarecalledintoquestion.GlobalfinancialassetsaspercentofGDPhavecontinuedtoincrease,withlessthan5%securedbysmartcontractingplatforms—adynamicconsistentwiththeadoptioncurveofdialupinternet.At1%,thegrosstakefromtokenizedassetsondecentralizedprotocolsislessthanathirdofthefeesthattraditionalfinancialinstitutionsextract.Applicationprotocols,whichpayalargershareoffeestoincentivizenetworkparticipants,accountfor75%ofgrossdecentralizedprotocolrevenues.TheblendednettakeratebetweenapplicationlayerprotocolsandLevel1protocolsisroughly60bps.Smart
ContractsDigitalwalletsenablenearlyeverypersonwithaconnecteddevicetotransmitandreceivemoneyinstantly,fundamentallytransformingtheRoughly90%ofsmartphoneusersrelyondigitalwalletstosomedegree.Themajorityusesdigitalwalletsasthefront-endformorethanhalfofmeaningfulthrough-flowofcommercialandfinancialexperiences.Digitalwalletsthatfacilitatewholesalepricingoffinancialservicesforindividualusershavefinancialfunctions.Digitalwalletplatformproviderscontinuetorelyontraditionalecosystemstofacilitatefinancialactivitieslikelendingbutcan
extractleaddisruptedretailbankingrelationships,fundamentallytransformingconsumer
generationfeesof5-20%fordeliveringcustomerstothoseinstitutions.Theyalsorelationshipswithfinancialserviceproviders.In
additiontotheirfinancialfunctions,digitalwalletsaredistributionplatformsforavarietyofdigitalcan
capture3-10%commercefacilitationfeesfore-commerceactivitydirectedthroughtheirplatforms.DigitalWalletsservices—fromride-hailingtoe-commerce—andaresecurerepositoriesfordigitalhealthandothersensitivedata.Traditionalfinancialserviceinstitutionsandtheirassociatedpaymentprocessingvaluechainshavegivenwaylargelytointernet-enableddigitalwalletsformosteconomicactivity.Sources:ARKInvestmentManagementLLC,2024.Intheabovetable,we
characterizetheconvergenttechnologicalcapabilitiesthatwebelievemaymanifestby2030and2050.Westressthatthesescenarios,writteninthepresenttense,arepossibleoutcomes—notassuredoutcomes—andthatthefuturemayplayoutdifferently.
ThisARKanalysisisbasedonarangeofexternalsources,whichmaybeprovideduponrequest.Forecastsareinherentlylimitedandcannotbereliedupon.Forinformationalpurposesonlyandshouldnotbeconsideredinvestmentadvice
orarecommendationtobuy,sell,orholdanyparticularsecurity.ExpectationsForMultiomic
Sequencing15Althoughthe
scenariosdescribed
inthe
table
beloware
writteninpresent
tense,
they
are
forecasted,
possible
outcomesbasedonARK'sviews.
These
possible
outcomesmay
not
be
realized
inthe
futuredue
to
a
number
of
uncertainties.
The
informationprovided
should
not
be
considered
investment
advice
and
should
not
formthe
basisof
any
investment
decision.Technology2040PossibilitiesARK’s2030Expectationof
ProgressTechnologyenablesthemanipulationofmolecularbiologicalsystems,catalyzinganewgenerationofmoreefficaciousanddurableprecisiontherapies.CRISPR-basedgene-editingenablesthemanipulationofDNAdirectlywithincreasingspecificity.RNA-actingtherapeutictechniquesrestricttheareaofDNAthatcan
betranscribedintoproteins.AI-advancesenablethetargetingofspecificproteinsthatcauseunderlyingdisorders.Thesebreakthroughshaveshorteneddevelopmenttimelinesforandincreasedtheefficacyofcurativetherapiesthatcommandhigherpricesthantraditionaltherapies.Researchersareaimingtocuremostrarediseases.Traditionalhealthservicespendingdeclines,cedingeconomicterraintomolecularcures.Precisiontherapiesmakeup25%ofnewlyreleaseddrugs.Byimprovingthequalityoflife,loweringancillarymedicalcosts,andofteneffectivelycuringdiseases,theycommandaveragepricepremiumsof7xrelativetotraditionaldrugs.CombinedwithexpectedimprovementsinR&Defficiencies,thesedrugsadd15%or~$300billiontodrugrevenuesin2030.Precision
TherapiesCatalyzedbytheprecipitousfallinsequencingcosts,researchersandcliniciansroutinelycollectpatients’epigenomic,transcriptomic,andproteomicdata.WithincreasinglycomprehensivedigitalhealthreadoutsfromintelligentdevicesandemergingAItools,theyalignthispanoplyofmultiomicdatatounderstand,predict,andtreatdisease.Asaresult,cancercarehastransformedcompletely:multiomictechnologiesdetectcanceratearlystages,targettreatmentmoreprecisely,andproviderecurrencemonitoring.Regularblood-basedpan-cancertestsareastandardofcareforpatientsinmiddleage.MultiomictechnologyhasincreasedbiotechR&Defficiency,asclinicaltrialstargetpatientpopulationsandmeasureoutcomesmorepreciselyandeasily.CombinedwithAI,multiomictechnologyhastransformedtherelationshipbetweenpatientsandhealthsystems.Digitalhealthproviders,diagnostictoolcompanies,andmoleculartestingcompaniesareleadingthecharge.Legacydrugfranchisesandhealthservicesystemshavelosttheirprominence.Wastefulhealthcarespendingdeclinesashealthylivesextend.Atfullpenetration,R&Defficiencyassociatedwithdrugdevelopmentcoulddouble,thankstoAI-enhancedmultiomictechnology.By2030,nearlyallnewdrugdevelopmentprogramsincorporatemultiomicsintopreclinicalR&D,and~50%incorporateAIintoclinicalprograms.RealizedreturnsonR&Dhaveimprovedby10%withline-of-sighttoaneardoublingofR&Dreturnsby2035.Earlydetectionmulti-cancerbloodtestshavebecomestandardofcareastheyhavecutcancermortalityby25%forsomeagecohorts.Indevelopedmarkets,30%ofpatientsbenefitfromthenewdiagnosticsregime.Multiomic
TechnologiesAItools,improvedgenomicsynthesistechniques,andscalablebiologicalmanufacturingtechniquesenablenovel,lowercostbiologicalconstructswithpredictableperformance,poweringarenaissanceinagricultureandmaterialsscience.Programmablebiologyenablesbreakthroughsinmaterialsscienceandbio-basedfuelsthatincreasefoodproductionandreduceenvironmentalexternalities.Molecularbiologicalprimitivesofferasubstratefornewrobustcomputationarchitectures.Stillrestrictedtoearlystageanddevelopmentprojects,gene
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