短链脂肪酸在肝缺血再灌注损伤中的研究进展

杆菌属等厌氧菌[12-13]。外源性SCFAs是体内SCFAs的主要来源，故本文主要围绕外源性证据表明，产生丁酸盐的细菌与潜在的发病机制之间存在关系[15-17血浆中的SCFAs,乙酸盐所占比例最高，主要由厌氧菌发酵碳水化合物生成，部分来自中已鉴定出3种丙酸盐合成途径，即：琥珀酸酯、丙二醇和丙烯酸酯途径。琥SCFAs作为肠道微生物代谢的主要产物，在[1]ZhaiY,PetrowskyH,HongJC,etal.Ischaemi肝胆外科杂志，2022,28(7):542-546.DOI:10.3760/的影响[J].中华肝胆外科杂志，2023,29(8):615-621.DOI:10.3760/113884-[5]0hiraH,FujiokaY,KatagiriC,etxhibitsneuroprotectiveeffectsforischemicstrokein[J].JNeuroinflammation,2016,13(1):300.DOI:10.1186/s12974-016-0765-6.[7]MorrisonDJ,PrestonT.Forcrobiotaandtheirimpactonhuman200.DOI:10.1080/19490976.2015.1134082.itsderivedbutyrate[J].ClinSci(Lond),2022/CS20240997.[9]XiaT,HeW,LuoZ,etacromol,2024,270(Pt2):132256.DOI:10.1016/j.ijbiomac.2024.132256.[10]DuanH,HuJ,DengY,etal.Berberinemediatestheproductionos,2023,16(1):9.DOI:10.3390/nu16010009.CellCommunSignal,2023,21(1):212.DOI:10.1186/s12[12]KohA,DeVadderF,Kovatcheva-DatcharyPostphysiology:short-chainfattyacidsaskeyba[J].NatRevMicrobiol,2021,19(1):55-71.DOI:10.1038/s41579-020-0433[14]GasalyN,deVosP,HermosoMA.Impactofbacterialmetabolitesongutbarrierfunctionandhostimmunity:afocusonbacvanceforintestinalinflammation[J].FrontImmu[15]PozueloM,PandaS,SantiagoA,etal.Reductionofbutyrate-an-producingmicroorganismsinpatientswithirritablebowelsyndrome[J].Sci2015,5:12693.DOI:10.1038/sre[16]SampsonTR,DebeliusJW,ThronT,etaficitsandneuroinflam6,167(6):1469-1480.e12.DOI:10.1016/j.cel1.2016.11.018.[17]BultmanSJ.Bacterialbutyra2018,3(12):1332-1333.DOI:10.1038/s41564-018-0299-z[18]YingXD,WeiG,AnH.SodiumbutyraterelieveslungisPharmacolSci,2021,25(1):413-422.DOI:10.26355/eurrev_202101_24409[19]AndohA.Physiologicalroleofgutmicrobiotaformaintaininghumanhealth[J].Digestion,2016,93(3):176-181.DOI:10.1159/[20]ReichardtN,<x>Dunc</x><x>anibutionofthreepathwaysforpropionateproductionwitiota[J].ISMEJ,2014,8(6):1323-1335.DOI:10.1038/ismej.2014.14.fdietarypropionate:studiesinwholeanimalsandperfusedratliver[J].AnnNutrMetab,1988,32(2):95-107.[22]JanG,BelzacqAS,HaouziD,etal.Propionibacteriainduc[J].CellDeathDiffer,2002,9(2):179-188.DOI:10.1038/sj.cdd.4onalcircuits[J].NatRevGastroenterolHepatol,2023,20(7):447-461.DOI:038/s41575-023-00771-6.[24]LiuB,QianJ,WangQ,etal.Butyraepaticischemiareperfusioninju(8):e106184.DOI:10.1371/journal.pone.0106184.ntJMolSci,2022,23(10):5740.DOI:10.3390/ijms23105740.[26]HanSJ,KimM,Novitskydsynthesis[J].FASEBJ,2020,34(9):12083-12099.DOI:1[27]DarWA,SullivanE,Bynonrtransplantation:cellularandmolecularmechanisms[J].LiverInt,2019,39(5):788-801.DOI:10.1111/liv.14091.[28]CannistràM,RuggieroM,ZulloA,etaury:asystematicreviewofliteratureandtheroleofcurrentdrugsandbiomarkers[J].IntJSurg,2016,33:Suppl1-S57.70DOI:10.1016/j.inhepaticischemia/reperfusioninjury[J].Bate,mesa-lamine,andfactorXIIIinexperimentalntransglutaminaseactivity[J].Gastroenterology,1994,106(2):399-404.DOI:10.servesasanadaptivestrategycelldeath[J].CellDeathDiffer,2011,18(4):602-618.DOI:10.1038/cdd.201[32]Jiménez-CastroMB,Cornide-PetronioME,Gracome-mediatedinflammationinliver8(10):1131.DOI:10.3390/cells8101131.shortchainfattyacids[J].[35]SunJ,WuQ,SunH,etal.Inhibitionofhistonedeacetylasebybutyrateprotectsratliverf(11):21069-21079.DOI:10.3390/ijms151121069.ressesautoimmunitybymodulatytes[J].Nat