雨课堂学堂在线学堂云分子影像学进展山东大学单元测试考核答案

注：不含主观题第1题ThesignalproducerinMIimagingispositron-decaynuclide.()第2题Molecularrecognitionisthebasisofmolecularimaging.()第3题Molecularimagingisinvitrodiagnosticimagingonmolecularlevel.()第4题Radionuclidelabeledprobesisusedinnuclearmedicalmolecularimaging.()5Radionuclidelabeledprobesisusedinnuclearmedicalmolecularimaging.()5Radionulcidetracingtechniqueisakeymethodinnuclearmedicine()第5题Themostimportantfeaturesofmolecularimaging:()ANon-invasiveBInvivoCReal-time

DVisualization正确答案：ABCD第6题MolecularRecognitionTheoryinclude:()AAg-AbBReceptor-ligandCProtein-nuclideDNuclide-nulcide正确答案：ABCD第7题Molecularprobesinclude:()AradionuclidelabeledprobesinnuclearmedicalimagingBmolecularprobesformagneticresonanceimagingCfluorescenceandchemiluminescenceprobesforopticalimagingDmicrobubblemolecularprobesforultrasoundmolecularimaging正确答案：ABCD第8题Molecularimaginginclude:()ARadionuclideimagingBMagneticResonanceImaging(MRI)CUltrasound(US)DOpticalimaging正确答案：ABCD第9题Thereceptorimagingcouldbeobtainedby:()ARadionuclideimagingBMagneticResonanceImaging(MRI)COpticalimagingDAllabove第10题Whatpropertyofradionuclidelabeledprobeusedinmolecularimaging?()ASimpleultrasoundBReflectiononlyCIonizingradiationDnonofabove第11题WhichofthefollowingradioisotopeusedinPETScan?()A99mTcB131IC125ID18F第12题Themolecularprobecomposedoffollowing?()ASignalBCarrierCSpecificligandDAllabove第13题Multimodalitymolecularimaginginclude?()APET/CTBPET/MRCPET/OpticDAllabove第14题Thekeyfactorsofmolecularimagingtechnology:()Ahigh-specificmolecularprobeBappropriatesignalamplificationtechnologyCdetectionsystemthatcanobtainhigh-resolutionimagessensitively.DAllAbove第15题5.Radionulcidetracingtechniqueisakeymethodinnuclearmedicine（√）第2章章节作业第1题Radioactivityisquantitativelymeasuredasthenumberofatomsthatdisintegrateperunittime.()第2题Alphaparticleshaveachargeofplus4.()第3题γdecayhaveachargeofplus/minus1.()第4题Chargedparticlecanionizesomeoftheatomswhichliealongitspathasittransversesthematter.()第5题ThefrequencyofBremsstrahlungdecreasedwhenittransversethematterwithhighatomicnumber.()第6题Forthesamenuclide,whichcharactermustbeidentical?()AProtonnumberBNeutronnumberCElectronsnumberDEnergystate正确答案：ABD第7题DuringtheAlpha-decay:()AAtomicnumberdecreasedby2BAtomicmassdecreasedby4CAtomicnumberunchangedDAtomicmassunchanged正确答案：AB第8题DuringtheisomericDecay:()AAtomicnumberincreasedby1BAtomicnumberunchangedCAtomicmassunchangedDFrommetastabelstatetogroundstate正确答案：BCD第9题TheInteractionofchargedparticleswithmatterinclude:()AIonizationBExcitationCScatteringDBremsstrahlung正确答案：ABCD第10题TheInteractionofphotonswithmatterinclude:()APhotoelectricinteractionBComptonelectronproductionCPairproductioninteractionDNoneabove正确答案：ABC第11题Nuclideswiththesamenumberofprotonsbutdifferentnumbersofneutrons,wecalledthem:()AIsotopeBIsomerCStablenuclideDUnstablenuclide第12题Theinternationalsystemofradioactivityunitsis()Acurie(Ci)Bbecquerel(Bq)CMeVDNoneofallabove第13题WhichkindofHalf-timeoftheNuclearMedicineonlydescribethetimerequiredforhalfofaradioactivesampletodecay?()APhysicalhalf-life

(T1/2)BBiologicalhalf-life（Tb）CEffectivehalf-life

(Te)DNoneofallabove第14题Duringɑdecay,theradioactivenucleusreleasedthealphaparticle.ThealphaparticleisinfacttheNucleusof.()AOxygenBHydrogenCHeliumDNoneofallabove第15题Whichkindofradioactivedecayhavenocharge?()AɑDecayBβDecayCPositronDecayDγDecay第3章章节作业第1题ThecomponentsofNMimagingdeviceNMimagingdeviceusuallycomposedby:()AScintillationCrystaldetectorBPhotomultipliertube(PMT)CElectricalcircuitsDNoneofabove正确答案：ABC第2题AsforNMImagingdevice,theenergyconversionhappenedin().APhotomultipliertubeBScintillationCrystaldetectorCElectricalcircuitsDNoneofabove正确答案：AB第3题LiquidScintillationCounterdetecttheLowenergybetaemitters,suchas()A3HB32PC14CD35S正确答案：ABCD第4题WhichradionuclidecanbeusedforPET:()A18FB11CC15OD13N正确答案：ABCD第5题Whichisotopeissuitablefordiagnostic:()A99mTcB111InC18FD90Y正确答案：ABC第6题LiquidScintillationCounterccanbeusedtodetect?()A3HB125IC18FDXray第7题ThisfunctionoftheCollimatorinScintillationcamerais()AChangetheradiationenergyofrayintophotonsBReceivethephotonsejectedfromtheCrystalandoutputelectricalsignalsCFiltersastreamofrayssothatonlythosetravelingparalleltoaspecifieddirectionareallowedthrough.DNoneofaboveall第8题RadiopharmaceuticalsusedforPETemit()AɑparticlesBβ-particlesCγrayDPositron第9题WhichistheFusedImagingTechnology?()ASPECT/CTBPET/CTCPET/MRIDAllabove第10题ThecommondenominatorinalloftheNMdevicesistheconversionofenergyintheformof()into(),recordedandprocessedbydedicatednuclearmedicinecomputersystems.()AelectricalenergyintoionizingradiationBionizingradiationintoelectricalenergyCionizingradiationintothermalenergyDthermalenergyintoionizingradiation第11题ThebasicprincipleofNMdevicesinistheconversionofenergyintheformofionizingradiationintoelectricalenergy()第12题WhatissimilarbetweenNuclearMedicineimaging&Traditionalimaging,isthattheyallfocusonthemorphologyinformationoftheorgans,tisssues.()第13题Themostcommonlyusedscintillationcrystalissodiumiodide.()第14题AsforFusedImagingTechnology,Wecanseethemetabolicactivityofthedisease&theexactpositionofthediseasesimultaneously.()第15题IdealDiagnosticRadiopharmaceuticalusuallyPhotonAbundance.第4章章节作业第1题Radionuclidesonlyemitradiationduringthemetabolictransformationoftracers,justshowedtheroleoftracerinvivo.()第2题RadiotracersarethebasisofaMIimagingsystems.()第3题Inthyroidglandimaging,appearanceofa"hotspot",meansafocaldecreaseinradioaccumulation.()第4题TheprocessofRadionuclideimagingInnuclearmedicineimaging,radiopharmaceuticalsaretakeninternally()第5题Differentradiopharmaceuticals(imagingagents)havetheirownspecialdistributionandmetabolicrulesinvivo.()第6题Receptorradioimagingistheintroductionofradionuclide-labeledligandsintothebodyinvivo.()第7题Thequantityofreceptorsinthebrainisverylow,soradioligandswepreparedmusthavehighaffinityandspecificactivitytopassthroughtheblood-brainbarrierwithoutparticipatinginmetabolisminvivo()第8题Themostimportantfeaturesofradiotracingteniqueare()()AIdentitybetweenlabeledandnonlabeledcompoundBMeasurabilityofradionuclideCenergyofradioisotopeDAllabove正确答案：AB第9题Radiotracingtechiniqueinvitroincludefollowings:()ATracingofMaterialMetabolismandTransformationBCytokineticsanalysisCradioimmunoassayDthyroidscanning正确答案：ABC第10题Invivoradiotracingtechniquesincludefollowings:()AAbsorption,distributionandexcretionofsubstancesBAutoradiographyCDeterminationoforganfunctionDRadionuclideImaging正确答案：ABCD第11题Radionuclideanditscompoundcangiveoutavarietyof()AgammaorbetaoralpharaysBcanbemeasuredbyradioactivitydetectorCrecordedbythephotosensitivematerialDAllabove第12题Characteresticofradionuclidetracingtechnique:()AHighsensitivityBThedetectivemethodissimple,accurateCtheamountofchemicalrequiredisverysmallDallabove第13题Thebiologicalbehaviorofradionuclidetracersinvivomainlydependson()AlabeledsubstancesBchemicalsubstanceonlyCradioisotopeonlyDAllAbove第14题Radioactivetracerscouldbedetectedby()AGammacounterBLiquidscintillatedcounterCPETDAllabove第15题Theadvantageofinvivoradioimagingincludethefollowing:()AQualitativeBQuantitativeCPositioningDAllabove第16题SPECTimagingusefollowingradioisotope:()A18FB99mTcC11CD15O第17题Radionuclideanditscompoundusingforinvivoimagingcangiveoutthefollowings:()AGammaraysBBetaraysCAlpharaysDAllabove第5章章节作业第1题99mTc-CEAFabhasgreatvalueindetectingprimaryandmetastaticcolorectalcancerinsideandoutsidetheliver,aswellaslymphmetastasisofbreastcancer.()第2题Tc-99mlabeledAnnexin-V,ahighaffinitymoleculeforphosphatidyl-serinewhichisexpressedincellplasmaintheterminalstagesofapoptosis.()第3题Geneimagingisthemostmaturetechnologyinmolecularnuclearmedicineandhasbeenwidelyusedinclinicaldiagnosis.()第4题Reportergeneimagingcanbeused:()AtomonitorendogenousgeneexpressionBstudygenedeliveryinanimals,Cselectthebestgenedeliverymethod.Dstudygeneexpressioninanimals正确答案：ABCD第5题Commonlyusedradioisotopesinradioimmunoimaging:()A131IB11CCFluoro-18D99mTc正确答案：AD第6题Nowdaysusedinclinicforgeneiamginginclude:()ACarcinoembryonicantigengene:radioiodineCOL-1imagingBDopaminetype2receptorgene:11C-racloprideCSodium/IodineSymportergene:radioiodineimagingDNoneofallabove正确答案：ABC第7题Principleofreportergeneimaging()AThereportergenedrivenbythepromotercanbetransferredintothecell.Btheexpressedproteincanbecapturedbytheprobetargetingthereportergeneprotein.Cifthereisnoproteinencodedbythereportergeneinthecell,theprobeentersthecellandflowsout,andisquicklyremovedfromtheblood.DAllAbove第8题Aboutradioimmunoimagingwhicharecorrect?()ASpecificmonoclonalantibodiesarelabeledwithradionuclidesBcanbecombinedwithtumorcell-relatedantigensspecificallyinvivo.CThesize,locationoftumorcanbedisplayedbySPECTorPET.DAllabove第9题Whichisthemostfamousmoleculeinmetabolicimaging?()ACEABAFPCGlucoseDFDG第10题WhichisusedinApoptosisimaging?()ATc-99mlabeledAnnexin-VBTc-99mlabeledAnti-CEACTc-99mlabeledgenereporterD18F-FDG第11题ThetargetprobeusedinApoptosisimagingis()AGlucoseBCEACGenereporterDAnnexin-V第12题Whichisthemostmaturetechnologyinmolecularnuclearmedicine?()AGeneimagingBMetabolicimagingCApoptosisimagingDRadioimmunoimaging第13题Aboutgeneimaging,whichoneiscorrect?()AIfthereisnoproteinencodedbythereportergeneinthecell,theprobeisquicklyremovedfromthebloodBAllgeneinvivosuitablegeneimagingCOnlyDNAcanbedetectedDAllabove第14题Geneimagingistouseradionuclidelabeledagent(probe)todisplaythefunctionaldynamicchangesofgeneanditsexpressionproductsatthelevelofDNA,mRNAorprotein.第15题Antisenseimagingisbasedontheprincipleofantisensecomplementationtopreparetheoligonucleotidechain(ASON)whichcomplementarytothespecificsequenceoftargetDNAorRNA.Byinvivohybridization,displayingthetargetsequence.

第6章章节作业第1题PETisaninvasive,diagnosticimagingtechniqueformeasuringthemetabolicactivityofcellsinthehumanbody.()第2题PETcanproduceathreedimensionalimageoffunctionalprocessinthebody.()第3题NotalltypesofcancercanbedetectedthroughPETscans,becausesometypesofcancerislowmetabolism.()第4题PET/CTscancanassesstheeffectivenessofatreatmentplan,suchascancertherapy.()第5题82Rbcanusedformyocardialperfusionimaging.()第6题18F-FDGcannotbeusedfordiagnosisofepilepsy.()第7题WhichisotopescanusedinPETscan?()ACarbon-11BTechnetium-99mCFluorine-18DGallium-68正确答案：ACD第8题When18FDGistransportedacrossmostcellmembranes:()AitdiffusesbackoutofthecellimmediatelyBitdiffusesbackoutofthecellinabout3hoursCitistrappedinthecellDitisnotfurthermetabolized正确答案：CD第9题PETscancanbehelpfulinidentifyingwhichtypesofcancer?()ABrainCancerBColorectalCancerCHeadandNeckCancerDPancreaticCancer正确答案：ABCD第10题PET/CTcanusedto_____foroncologicalapplication.()AdiagnoseBstageandrestageCtherapeuticmonitorDevaluateoftherapeuticeffect正确答案：ABCD第11题WhichofthefollowingdescriptionsaboutAlzheimer’sdiseasearetrue:()AAlzheimer’sdiseaseshowprogressiveandirreversiblememorylossandbehavioralchanges.BSPECTstudiesshowdecreasedperfusionandmetabolism,respectively,inthetemporal,parietal,posteriorcingulateandprefrontalcortices.CFDG-PETstudiesshowdecreasedperfusionandmetabolism,respectively,inthetemporal,parietal,posteriorcingulateandprefrontalcortices.DThisdiseaseclassicallyaffectsbothsidesofthebrain.正确答案：ABCD第12题ApatienthasundergonemyocardialPETscansusing82Rband18F-FDG.Thereislittleinferoapicalactivityonthe82Rbscan,butthereishomogeneousuptakeinthesameareaonthe18F-FDGimages.Thissuggeststhat:()Aanincorrectdoseof82Rbhasbeenadministered.Btheinferoapicalareamayrevascularize.Cthereislittleviabletissueintheinferoapicalwall.Dthesystemrequiresaqualitycontrolcheck.第13题Theimageof18F-FDGinepilepsyshows:()Ahighuptakeinseizurephase,lowinseizure-freephaseBlowuptakeinseizurephase,highinseizure-freephaseChighuptakeinbothseizureandseizure-freephaseDlowuptakeinbothseizureandseizure-freephase第14题Normal18F-FDGdistributionwouldshowtheleastactivityinthe:()AbrainBboneCbladderDmyocardium第7章章节作业第1题Opticalimagingisanimagingtechnique,onlydescribesthebehaviorofvisiblelightusedinimaging.()第2题Opticalimaginghastheadvantagesofnon-ionizingradiation,allowsforrepeatedstudiesovertime.()第3题Opticalimagingisnotamenabletomultimodalimaging,easilycombinablewithotherimagingtechniques()第4题Opticalimagingsystemsmaybedividedintodiffusiveandballisticimagingsystems.()第5题Opticalimagingisanimagingtechnique,usuallydescribesthebehaviorof()lightusedinimaging.()AvisibleBultravioletCinfraredDX-rays正确答案：ABC第6题TheAdvantagesofOpticalimaginginclude()Anon-ionizingradiation,allowsforrepeatedstudiesovertime.Bthepotentialtodifferentiateamongsofttissues,andbetweennativesofttissuesandtissuelabeledwitheitherendogenousorexogenouscontrastmedia.CAgreatpotentialforprovidingspecifictissuecontrasts,andofferspotentialcapabilitiesforstudyingfunctionalandmolecularlevelactivities.DOpticalimagingisveryamenabletomultimodalimaging,easilycombinablewithotherimagingtechniques.正确答案：ABCD第7题Fluorescenceimagingisthevisualizationof.()AfluorescentdyesBproteinsCproteinsaslabelsformolecularprocessesorstructuresDAllAbove正确答案：AC第8题Opticalimagingsystemsmaybedividedinto()imagingsystems.()AdiffusiveBandX-raysCandballisticDAllAbove正确答案：AC第9题NearInfraredcomparedwithOtherImagingModalitieshastheadvantagesof().()ADeeppenetrationintobiologicaltissueBNon-invasiveCNon-radioactiveDRealtimefunctionalimaging正确答案：ABCD第10题Opticalimagingisanimagingtechnique,usuallydescribesthebehaviorof()usedinimaging.()Avisiblelight,Bultravioletlight,Cinfraredlight.Dvisible,ultraviolet,andinfraredlight.第11题Opticalimaginginvivomainlyuses()bioluminescenceandfluorescencetechnologytolabelcellsorgenes.()Abioluminescencetechnology,Bfluorescencetechnology.Cbioluminescenceandfluorescencetechnology,DNonofallabove第12题Opticalimaginghastheadvantagesof().Anoradiation,Bgoodstabilityoflabeledcompounds,Csuitableforrepeatedimagingafterasingleinjectioninvivo.DAllabove.第13题Opticalimagingsystemsmaybedividedinto()imagingsystems.()Adiffusive,Bballistic,Cdiffusiveandballistic,DNonofallabove.第14题Fluorescenceimagingenablesawiderangeofexperimentalobservationsincluding()incellsandtissues.()Athelocationanddynamicsofgeneexpression,Bproteinexpression,Cmolecularinteractions,DAllabove.第15题Bioluminescenceimaging(BLI)doesnotreliyondetectionoflightfromluciferase-expressingcellsinananimal.第8章章节作业第1题MolecularMRIissimilartomolecularimaging()第2题TheapplicationofmolecularMRIisearlierthanthatofanatomicalMRI.()第3题MRmolecularimagingneedsspecificmarkers.()第4题Specificimagingtargetisoneofthekeypointsofmolecularimaging.()第5题TherequirementofMRmolecularimagingforMRimagingresolutionisnothigh.()第6题Therelationshipbetweenpassivetargetandactivetarget()AthetwocanpromoteeachotherBthetwocancooperatewitheachotherCthetwocannotexistatthesametimeDtheabovethreeitemsareallright正确答案：ABCD第7题Bimodalimagingcanbecombined()AmagneticresonanceimagingandphotoacousticimagingBmagneticResonanceimagingandultrasoundimagingCphotodynamicimagingandphotoacousticimagingDphotodynamicimagingandultrasoundimaging正确答案：ABCD第8题Thefollowingcanbeusedasatarget()ApeptideBreceptorCspecificenzymeDtheaboveall正确答案：ABCD第9题Targetscanbedividedinto()AextracellularBcellmembraneCintracellularDtheaboveall正确答案：ABCD第10题Theronosticsiscombined()AdiagnosisBtreatmentCprognosisDprevention正确答案：AB第11题TherelationshipbetweenMRmolecularimagingandmolecularimagingis().AMRmolecularimagingisanimportantbranchofmolecularimaging.BMolecularimagingisanimportantbranchofMRmolecularimaging.CTheyarethesameconcept.DThereisnorelationshipbetweentheboth.第12题TheconceptofMRmolecularimaging:()AUsingCTimagingtechnologytoimagespecificbiomoleculesinvivo,inordertoachievethepurposeofearlyandspecificdiagnosisandmonitoringoflesions.BInordertoachievethepurposeofearlyandspecificdiagnosisandmonitoringoftreatmenteffect,MRimagingisusedtoimagespecificbiomoleculesinvivo.CFluorescenceimagingtechnologyisusedtoimagespecificbiomoleculesinvivo,soastoachievethepurposeofearlyandspecificdiagnosisandefficacymonitoring.DUltrasoundimagingtechnologyisusedtoimagespecificbiomoleculesinvivo,soastoachievethepurposeofearlyandspecificdiagnosisandcurativeeffectmonitoring.第13题WhichofthefollowingisnecessaryforMRmolecularimaging?()ASpecificmarkerofthelesion.BMRimagingequipment.CMagneticmolecularprobe.DAlloftheabove.第14题TherelationshipbetweenfunctionalMRIandanatomicalMRIis()AComplementandpromoteeachother.BNoconnectionbetweenboth.CFunctionalimagingcanreplacetheanatomicalimaging.DAnatomicimagingismoreimportantthanfunctionalimaging.第15题Asforthesignalstrengthoftissues,whichofthefollowingiscorrect?()ATheshortertheT1,thestrongerthesignal;theshortertheT2,thestrongerthesignalBThelongertheT1,thestrongerthesignal;thelongertheT2,thestrongerthesignalCTheshortertheT1,thestrongerthesignal;theshortertheT2,theweakerthesignalDThelongertheT1,theweakerthesignal;thelongertheT2,theweakerthesignal第9章章节作业第1题Molecularimagingoftumorisoneofthemostactiveresearchfields.()第2题Glucosamine,peptidesandproteinscanbeusedasprobes.()第3题OnlygadoliniumammoniumspraycanbeusedasMRcontrastagent.()第4题Tumorigenesisisrelatedtothechangeofmicroenvironment.()第5题Atpresent,molecularimagingtechnologycannotrealizethereal-timemonitoringoftheinteractionbetweentumorcellsandtheirsurroundingmicroenvironment.()第6题Inthecardiovascularfield,molecularimaginginvolvesatherosclerosisandplaque.()AapoptosisBinflammationCmetabolismDstemcelltherapy正确答案：ABCD第7题Inthefuture,theavailablewaystoimprovetheeffectofMRmolecularimageinclude()AimagingsensitivityBhighfieldstrengthequipmentCCESTimagingDhyperpolarizedMRimagingandhighercontrastmolecularprobes正确答案：ABCD第8题Intheprocessofatheroscleroticpathophysiologicaldevelopment,imagingtargetsoftheplaqueinclude:()AendothelialcellBinflammatorycellCnoncellularcomponentDbloodcell正确答案：ABC第9题Themolecularimagingforstemcellsincludes()AnuclearmedicalmolecularimagingBMRmolecularimagingCultrasonicmolecularimagingDfluorescenceimaging正确答案：ABCD第10题Theimagingofproteaseactivityofmacrophagesishelpfulfortheevaluationofatheroscleroticorhearttransplantrejectionwith()imagingprobes.()AactivatedfluorescenceprobeBradionuclideinhibitorCnanoparticleDmonoclonalantibody正确答案：AB第11题Themostcommonnoncellularcomponentofplaquesasbiologicaltargetis:()AcollagenBatheroscleroticplaquesCendothelialDlipidplaques第12题Intheatheroscleroticmodel,()afterinjectioncanbeengulfedbymacrophagesintheplaqueandproducesignificantsignalchangesintheplaque.()AUSPIOparticlesBphageCantibodyDantigen第13题Thehigh-riskvulnerableplaquecanbedetectedthroughmarking()inimaging.()AlipidBapoptosisCerythrocyteDnecrosisEangiogenesisFautophagyGendothelialcells4.Molecularimagingofcardiovasculardiseasehelpstoshowthe()ofcells.(D)HAandB第14题Theimagingprobestodayareusedinatheroscleroticdiseaseorhearttransplantrejectioninclude:()AactivatedfluorescenceprobeBradionuclideinhibitorCnanoparticlesDAllofAbove第10章章节作业第1题Ultrasoundisnoninvasive,widelyavailable,portable,relativelyinexpensiveandallowsreal-timeimagingwiththeuseofionizingradiation.()第2题Ultrasoundmolecularimagingisbasedonthespecificacousticpropertiesofacousticallyactiveultrasoundcontrastagents,whichcanbesensitivelyimagedwithregularultrasoundmethods.()第3题Theconstructionofmicrobubblescontainsthematerialofshell,thegascoreandsurfacemodification.()第4题Microbubblesarelargebutcandiffusetotheintravascularspace.()第5题Solidandliquidnanoparticlestendtobelessechogenicthangasbubblesbecausetheyareincompressibleanddonotoscillatestronglywiththepassingacousticwave.()第6题Asanultrasoundpulsemovesthroughtissueinapatient’sbodyitwillundergoachangein:()AFrequency.BAmplitude(energy).CPhysicalsize.DIntensity.正确答案：BCD第7题Whichbelongtotheultrasoundcontrastagents()?()AMicrobubblesBNanodropletsCLiposomeDBubbicle正确答案：CAABCD第8题Whichofthefollowingaretrueabouttheultrasoundimagingsystem?()Aclinicalultrasoundimaginginstrumentationhasevolvedintopowerfularray-basedsystemscapableofrealtime1D,2Dandeven3Dor4DimagingBForcontrastimaging,