AbMole丨Resveratrol（白藜芦醇）：调控SIRT1、Nrf2与NF-κB信号通路的多靶点天然产物

AbMole丨Resveratrol（白藜芦醇）：调控SIRT1、Nrf2与NF-κB信号通路的多靶点天然产物AbMole丨Resveratrol（白藜芦醇）：调控氧化应激、炎症反应与能量代谢的多功能天然小分子Resveratrol（白藜芦醇，AbMole，M2267）是一种广泛存在于葡萄、浆果及花生等植物中的天然产物，因其多样的生物活性成为多个领域中的重要研究工具。其作用机制涉及抗氧化、抗炎、细胞衰老及对细胞信号通路的调节。Resveratrol（白藜芦醇）不仅可通过激活去乙酰化酶Sirtuin1（SIRT1）以影响免疫反应、能量代谢及细胞衰老等过程ADDINEN.CITEADDINEN.CITE.DATA[1]，还可以通过对PI3K/AKT、Wnt、NF-κB及Notch等信号通路的调控进而诱导细胞衰老，抑制细胞活力与集落形成ADDINEN.CITEADDINEN.CITE.DATA[2]。Resveratrol在小鼠模型中被发现可提升小鼠线粒体的功能、体力和葡萄糖耐受，并预防和缓解与衰老相关的症状ADDINEN.CITE<EndNote><Cite><Author>Park</Author><Year>2012</Year><RecNum>1445</RecNum><DisplayText><styleface="superscript">[3]</style></DisplayText><record><rec-number>1445</rec-number><foreign-keys><keyapp="EN"db-id="f2td9w00a22awteprfrp9vaup9d9zwa9tdfr"timestamp="1764035385">1445</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Park,Sung-Jun</author><author>Ahmad,Faiyaz</author><author>Philp,Andrew</author><author>Baar,Keith</author><author>Williams,Tishan</author><author>Luo,Haibin</author><author>Ke,Hengming</author><author>Rehmann,Holger</author><author>Taussig,Ronald</author><author>Brown,Alexandra

L</author><author>Kim,Myung

K</author><author>Beaven,Michael

A</author><author>Burgin,Alex

B</author><author>Manganiello,Vincent</author><author>Chung,Jay

H</author></authors></contributors><titles><title>ResveratrolAmelioratesAging-RelatedMetabolicPhenotypesbyInhibitingcAMPPhosphodiesterases</title><secondary-title>Cell</secondary-title></titles><periodical><full-title>Cell</full-title><abbr-1>Cell</abbr-1></periodical><pages>421-433</pages><volume>148</volume><number>3</number><dates><year>2012</year></dates><publisher>Elsevier</publisher><isbn>0092-8674</isbn><urls><related-urls><url>/10.1016/j.cell.2012.01.017</url></related-urls></urls><electronic-resource-num>10.1016/j.cell.2012.01.017</electronic-resource-num><access-date>2025/11/24</access-date></record></Cite></EndNote>[3]。在抗氧化方面，Resveratrol可直接清除活性氧（ROS）并调节细胞的氧化应激水平ADDINEN.CITEADDINEN.CITE.DATA[4]，例如Resveratrol可通过激活转录因子Nrf2促进抗氧化基因表达，并在细胞（如Hacat人角质形成细胞）中表现出抑制氧化损伤的能力ADDINEN.CITEADDINEN.CITE.DATA[5]。在免疫调节领域，Resveratrol（白藜芦醇，AbMole，M2267）表现出抗炎特性。例如Resveratrol可通过调节胞内的PPAR、AMPK和FoxO等通路影响小胶质细胞的活性，进而发挥抗炎的作用ADDINEN.CITE<EndNote><Cite><Author>Zhang</Author><Year>2010</Year><RecNum>1443</RecNum><DisplayText><styleface="superscript">[6]</style></DisplayText><record><rec-number>1443</rec-number><foreign-keys><keyapp="EN"db-id="f2td9w00a22awteprfrp9vaup9d9zwa9tdfr"timestamp="1764034822">1443</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Zhang,Feng</author><author>Liu,Jie</author><author>Shi,Jing-Shan%JEuropeanjournalofpharmacology</author></authors></contributors><titles><title>Anti-inflammatoryactivitiesofresveratrolinthebrain:roleofresveratrolinmicroglialactivation</title></titles><pages>1-7</pages><volume>636</volume><number>1-3</number><dates><year>2010</year></dates><isbn>0014-2999</isbn><urls></urls></record></Cite></EndNote>[6]。并且Resveratrol可抑制由Aβ1-42（Amyloidβ-Peptide1-42）在小胶质细胞和星形胶质细胞中引起的炎症反应，其机制涉及对NF-κB信号通路的抑制ADDINEN.CITE<EndNote><Cite><Author>Zhao</Author><Year>2018</Year><RecNum>1444</RecNum><DisplayText><styleface="superscript">[7]</style></DisplayText><record><rec-number>1444</rec-number><foreign-keys><keyapp="EN"db-id="f2td9w00a22awteprfrp9vaup9d9zwa9tdfr"timestamp="1764034983">1444</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Zhao,Haifeng</author><author>Wang,Qian</author><author>Cheng,Xuejiao</author><author>Li,Xuemin</author><author>Li,Na</author><author>Liu,Tiantian</author><author>Li,Jing</author><author>Yang,Qian</author><author>Dong,Ruirui</author><author>Zhang,Yusen%JNeuroscience</author></authors></contributors><titles><title>InhibitiveeffectofresveratrolontheinflammationinculturedastrocytesandmicrogliainducedbyAβ1–42</title></titles><pages>390-404</pages><volume>379</volume><dates><year>2018</year></dates><isbn>0306-4522</isbn><urls></urls></record></Cite></EndNote>[7]。Resveratrol还可影响细胞和机体的代谢，其机制涉及对cAMP降解磷酸二酯酶的竞争性抑制，导致cAMP水平升高，并影响细胞中的能量调节中枢--cAMP-MAPK通路ADDINEN.CITE<EndNote><Cite><Author>Park</Author><Year>2012</Year><RecNum>1445</RecNum><DisplayText><styleface="superscript">[3]</style></DisplayText><record><rec-number>1445</rec-number><foreign-keys><keyapp="EN"db-id="f2td9w00a22awteprfrp9vaup9d9zwa9tdfr"timestamp="1764035385">1445</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Park,Sung-Jun</author><author>Ahmad,Faiyaz</author><author>Philp,Andrew</author><author>Baar,Keith</author><author>Williams,Tishan</author><author>Luo,Haibin</author><author>Ke,Hengming</author><author>Rehmann,Holger</author><author>Taussig,Ronald</author><author>Brown,Alexandra

L</author><author>Kim,Myung

K</author><author>Beaven,Michael

A</author><author>Burgin,Alex

B</author><author>Manganiello,Vincent</author><author>Chung,Jay

H</author></authors></contributors><titles><title>ResveratrolAmelioratesAging-RelatedMetabolicPhenotypesbyInhibitingcAMPPhosphodiesterases</title><secondary-title>Cell</secondary-title></titles><periodical><full-title>Cell</full-title><abbr-1>Cell</abbr-1></periodical><pages>421-433</pages><volume>148</volume><number>3</number><dates><year>2012</year></dates><publisher>Elsevier</publisher><isbn>0092-8674</isbn><urls><related-urls><url>/10.1016/j.cell.2012.01.017</url></related-urls></urls><electronic-resource-num>10.1016/j.cell.2012.01.017</electronic-resource-num><access-date>2025/11/24</access-date></record></Cite></EndNote>[3]。AbMole为全球科研客户提供高纯度、高生物活性的抑制剂、细胞因子、人源单抗、天然产物、荧光染料、多肽、化合物库、抗生素等科研试剂，全球大量文献专利引用。范例详解

Biomaterials.2025Aug;319:123208.天津大学的科研人员在上述文章中使用了AbMole的Resveratrol（白藜芦醇，AbMole，M2267）进行了以下研究：首先实验人员开发了一种基于磷脂酰肌醇衍生物的新型生物正交标记策略，用于荧光标记来自各种人类和小鼠细胞类型的外泌体。发现不同细胞来源的外泌体表现出器官特异性分布模式和良好的安全性特征。值得注意的是，4T1细胞（一种乳腺癌细胞）来源的外泌体专门针对肺部，当其用作含有抗炎白藜芦醇（AbMole，M2267）的活性分子载体时，在急性呼吸窘迫综合征（ARDS）小鼠中表现出显著的症状抑制效果，有效减少了炎症反应和肺纤维化，并恢复肺组织的形态和功能ADDINEN.CITEADDINEN.CITE.DATA[8]。2014年，AbMole的两款抑制剂分别被西班牙国家心血管研究中心和美国哥伦比亚大学用于动物体内实验，相关科研成果发表于顶刊Nature和NatureMedicine。EvaluatingthetherapeuticefficacyoftheExo(R)fortreatingARDSmouseADDINEN.CITEADDINEN.CITE.DATA[8].AbMole是ChemBridge中国区官方指定合作伙伴。*本文所述产品仅供科研使用参考文献及鸣谢ADDINEN.REFLIST[1] MaF,MaY,LiuK,etal.ResveratrolinducesDNAdamage-mediatedcancercellsenescencethroughthedlc1-dyrk1a-egfraxis.Food&function,2023,14:1484-1497[2] Ghafouri-FardS,BahroudiZ,ShooreiH,etal.Disease-associatedregulationofgeneexpressionbyresveratrol:Specialfocusonthepi3k/aktsignalingpathway.Cancercellinternational,2022,22:298[3] ParkS-J,AhmadF,PhilpA,etal.Resveratrolamelioratesaging-relatedmetabolicphenotypesbyinhibitingcampphosphodiesterases.Cell,2012,148:421-433[4] AgbaduaOG,KuszN,BerkeczR,etal.Oxidizedresve