雨课堂学堂在线学堂云《Medical Virology（汕头）》单元测试考核答案

第1题Manyvirusesarehighlyspecificregardingthetypeofcellstheyinfect.Whichofthefollowingisthemostimportantdeterminantofthisspecificity?AThematrixproteinBThepolymeraseinthevirionCThesurfaceglycoproteinDTheproteaseproteinETheviralmRNA第2题Youstudythevirusesthatcauseupperrespiratorytractinfections.Youhaveisolatedavirusfromapatient’sthroatandfindthatitsgenomeisRNA.FurthermoreyoufindthatthegenomeisthecomplementofviralmRNAwithintheinfectedcell.WhichofthefollowingistheMOSTappropriateconclusionyoucoulddraw?AThegenomeRNAisinfectious.BThegenomeRNAissegmented.CThevirioncontainsapolymerase.DThevirionhasalipoproteinenvelope.EAsingle-strandedDNAissynthesizedduringreplication.第3题Thepurifiedgenomeofcertainvirusescanenteracellandelicittheproductionofprogenyviruses(i.e.,thegenomeisinfectious).Regardingtheseviruses,whichofthefollowingstatementsismostaccurate?ATheirgenomeRNAhaspositivepolarity.BTheirgenomeRNAisdouble-stranded.CTheyhaveapolymeraseinthevirion.DTheyhaveasegmentedgenome.ETheyrequiretegumentproteinsinordertobeinfectious.第4题WhichofthefollowingstatementiscorrectaboutRNAvirus?AAllRNAvirusesaresinglestranded.BMostarenakedviruses.CSomearesegmented.DAllcanintegratewithgenomeofhostcells.ERNAshouldbereversetranscribed.第5题ReversetranscriptaseenzymeispresentinAEBvirusBHumanimmunodeficiencyvirusCHerpessimplexvirusDSARS-CoV-2EInfluenzavirus第6题ThevirusesenterthehostcellsbyADirectpenetrationBCellfusionCEndocytosisDAlloftheabove第7题WhichgroupofvirusescarriesRNApolymerase?AdsDNABssDNAC-ssRNAD+ssRNAEdsRNA第8题EnvelopedvirusesareusuallyreleasedbyABuddingBCelllysisCFusionDEndocytosisEDirectpenetration第9题WhichofthefollowingmoleculeonBcellsisthereceptorofEpstein-Barrvirus?ACD4BCD8CICAM-1DCD21ECD19第10题TwodifferentstrainsofasegmentedRNAvirusinfectthesamecell.Majornewgeneticcombinationsareproducedthroughshuffling,resultinginstableanddramaticchanges.ThisphenomenaiscalledasAMutationBGenerecombinationCGenereassortmentDPhenotypicmixingEGeneticdrift第11题Iftwodifferentvirusesinfectacell,progenyvirusesmaycontaincoatcomponentsderivedfrombothparents.ThiskindofantigenicchangeofvirusiscalledAMutationBGenerecombinationCGenereassortmentDComplementationEPhenotypicmixing正确答案：E第12题Thesuffix“–viridae”referstotheviralAFamilyBGenusCSpecies第13题Whichofthefollowingpathogendoesnotcontainanygenome,justthemisfoldedproteins?AArbovirusBHIVCHepatitisvirusDPrionEViroid第14题Varicella-ZostervirusinfectionbelongstoAChronicinfectionBLatentinfectionCAcuteinfectionwithlatecomplicationDAsymptomaticinfectionEAllofabove第15题Whichofthefollowingis/arethemechanism/sofviralcytopathogenesis?AInhibitionanddegradationofcellularDNABAlterationofcellmembranestructureCViralglycoproteininsertionDSyncytiaformationEAlloftheabove正确答案：E第16题LaboratoryproceduresfordiagnosingviralInfectionsincludeAVirusisolationandgrowthBDetectionofviralproteins(antigensandenzymes)CDetectionofviralgenomesDSerologyEallofabove正确答案：E第17题Interferonsareafamilyofeukaryoticcellproteinsclassifiedaccordingtothecelloforigin.IFN-ɑandIFN-βareproducedbyavarietyofvirus-infectedcells.TheyAactontargetcellstoinhibitviralreplicationBactdirectlyonthevirusCarevirus-specificDallofabove第18题Theimmuneresponseisthebestandinmostcasestheonlymeansofcontrollingaviralinfection.ItconsistsofexceptAskinbarrierBNewlysynthesisofantigenCnaturalkillercellsDAntibodyECD4Tcells第1题Whichofthefollowingviralfamiliesdoesinfluenzavirusbelongto?AOrthomyxoviridaeBParamyxoviridaeCCoronaviridaeDTogaviridaeEAdenoviridae第2题Whichofthefollowingviruseshasasegmentedgenome?AFluvirusBMeaslesvirusCRubellavirusDMumpsvirusERSV第3题Whichoftheviralconstituentsisanionchannel?AM1BM2CNPDNSEHAFNA第4题Whichofthefollowingtestscouldbeusedtodetectthefluvirusinfectedcells?AHemagglutinationinhibitiontestBHemagglutinationtestCHemadsorptiontestDAlloftheaboveENoneoftheabove第5题MinorchangesofHAarecalledAGenemutationBGenereassortmentCAntigenicshiftDAntigenicdrift第6题Whichofthefollowinganti-fludrugsisaneuraminidaseinhibitor?AOseltaminvirBAmantadineCRimantadineDNoneoftheaboveEAlloftheabove第7题FluviruscanbedestroyedbyallthefollowingexceptAHeatedat56°Cfor30minBEtherCProteindenaturantsDLowtemperature第8题Thetype-specificantigen(A,B,orC)ofinfluenzavirusesisfoundonwhichviralconstituent?
AHemagglutininBNeuraminidaseCNucleocapsidDPolymerasecomplexEMajornonstructuralproteinFLipidintheviralenvelope第9题InfluenzavirustypeAusuallyproducesamild,self-limitedfebrileillnessinthegeneralpopulation.However,worldwideepidemicshaveoccurredatdifferenttimesinhistoryduetorapidchangesinviralgeneticmakeup.Whichofthefollowingisthemostimportantreasonwhythesesporadicworldwideepidemicsoccur?AAntigenicdriftBAntigenicshiftCHemagglutinindevelopstheabilitytodestroyacomponentofmucin,becomingmoreinfectiousDNeuraminidasedevelopstheabilitytoattachtosialicacidreceptors,becomingmoreinfectiousERBCsagglutinatewithcertainstrains第10题A19-year-oldstudentdevelopeda“flu-like”syndromewithfever,sorethroat,headache,andmyalgia.Inordertoprovidelaboratoryconfirmationofinfluenza,aculturefortheviruswasordered.Whichofthefollowingwouldbethebestspecimenforisolatingthevirusresponsibleforthisinfection?AStoolBNasopharyngealwashingCVesiclefluidDBloodESaliva第11题A75-year-oldfemalerefusedtheinfluenzavaccineandsubsequentlydevelopedinfluenza.Shediedofacutepneumonia1weekaftercontractingtheflu.Themostcommoncauseofacutepostinfluenzapneumoniaiswhichofthefollowing?ALegionellaBStaphylococcusaureusCMeaslesDCytomegalovirusEListeria第12题Rubellavirus,acommoncauseofexanthemsinchildren,isbestdescribedbywhichofthefollowingstatements?AMeaslesandGermanmeasles(rubella)arecausedbythesamevirus.BVesicularrashesarecharacteristic.CRubellacanbepreventedwithMMRvaccine.DSpecificantibodyintheserumdoesnotpreventdisease.ERubellaviruscanusuallycauseachronicdisease.第13题Thisvirusisasingle-strandedRNAorthomyxovirus.Annualvaccinationisnecessarybecauseofantigenicdriftandshift.AMeaslesvirusBInfluenzavirusCRespiratorysyncytialvirusDParainfluenzavirusEAdenovirus第14题Whichofthefollowingvirusesisasingle-strandedRNAparamyxovirus,andtherashknownasKoplikspots?AMeaslesvirusBInfluenzavirusCRespiratorysyncytialvirusDParainfluenzavirusEAdenovirus第15题Whichofthefollowingviruseswouldbetheleadingcauseofbronchiolitisandcommunity-acquiredpneumoniaininfants?AMeaslesvirusBInfluenzavirusCRespiratorysyncytialvirusDParainfluenzavirusEAdenovirus第16题Whichofthefollowingvirusesisaparamyxovirusandcausesthesyndromeknownascroup?AMeaslesvirusBInfluenzavirusCRespiratorysyncytialvirusDParainfluenzavirusEAdenovirus第17题Thisisadouble-strandedDNAvirus.Itisresponsiblefor15%ofpediatricrespiratoryinfectionsand10to15%ofacutediarrheainchildren.AMeaslesvirusBInfluenzavirusCRespiratorysyncytialvirusDParainfluenzavirusEAdenovirus正确答案：EVirusesTransmittedThroughFecal-oralRouteQuiz第1题Whichofthefollowingvirusescanbetransmittedbyfecal-oralroute?AHumanpapillomavirusesBPoxvirusesCHumanherpesvirusDCoxsackievirusEMeaslesvirus第2题Whichofthefollowingviruscancausehand-foot-and-mouthdisease(HFMD)?APoliovirus1BCoxsackievirusA16CEchovirus11DEV72EAlloftheabove第3题Herpanginaisaseverefebrilepharyngitis.ThemostcommonviralagentscausingherpanginaisAPoliovirusBCoxsackievirusACCoxsackievirusBDEchovirusEAlloftheabove第4题Whichofthefollowingvirusesisusuallyassociatedwiththeacutehemorrhagicconjunctivitis?AEV70BEV71CEV72DAllthetheabove第5题Allofthefollowingvirusescancausecommoncold-likesymptomsexceptACoxsackievirusA21BCoxsackievirusA24CEchoviruses11DEchoviruses20EPoliovirus1正确答案：E第6题EnterovirusesusuallycauseallofthefollowingdiseasesexceptAAsepticmeningitisBConjunctivitisCRespiratorytractinfectionsDPleurodyniaEMyocarditisFAcutegastroenteritis正确答案：F第7题Therearethreepoliovirustypes.Whichtypecausemostcasesofparalyticpolio?APoliovirustype1BPoliovirustype2CPoliovirustype3第8题Thesourceoftheinfectionofpoliovirusis/areAAsymptomaticcarriersBPatientswithabortivepoliomyelitisCPatientswithnonparalyticpoliomyelitisDPatientswithparalyticpoliomyelitisEAlloftheabove正确答案：E第9题PoliomyelitismainlyaffectsAChildrenunder1yearofageBChildrenunder5yearsofageCTeenagersDAdultsEPeopleinallages第10题HostresponsetopoliovirusmostlydependsonAhumoralimmunityBCell-medicatedimmunityCHumoralandcellular第11题ThegenomeofthefamilyPicornaviridaeisA+ssRNAB-ssRNACdsRNADssDNAEdsDNA第12题WhichofthefollowingviruseswithagenomeresemblingamRNAandsufficienttoinfectacell?AInfluenzavirusBMeaslesvirusCMumpsvirusDPoliovirusEDenguevirus第13题Apatientwithnuchalrigidityandheadacheundergoeslumbarpuncture.TheCSFcontainsmarkedlyincreasednumbersoflymphocytes,leadingtoapresumptivediagnosisofviralmeningitis.Whichofthefollowinggroupsofvirusesismostlikelytobeinvolved?AAdenovirusesBEnterovirusesCHumanpapillomavirusesDPoxvirusesEReoviruses第14题A10-year-oldboypresentstothephysicianwithfever,headache,andstiffneck.Examinationisremarkableforasymmetricweaknessandhyporeflexia.Hehasapoorimmunizationhistory,andpoliomyelitisisdiagnosed.Whatistheprimarymechanismbywhichpolioviruscausesparalyticdisease?ADemyelinationoflowermotorneuronaxonsBDemyelinationofuppermotorneuronaxonsCDestructionofcellbodiesoflowermotorneuronsDDestructionofmusclecellsEDestructionofsynapsesbetweentheaxonandthemuscle第15题A12-year-oldgirldevelopsmyopericarditiswithmildcongestiveheartfailurethatincreasesoverseveralweeks.CoxsackievirusB5infectionisdiagnosed.Whichofthefollowingclinicalsyndromesisalsoassociatedwithcoxsackievirusinfections?AHerpangina
BMyocarditis/pericarditis
CAsepticmeningitis
DAcutehemorrhagicconjunctivitisEAlloftheabove
正确答案：E第16题The“funship”leavesport.Onthethirddayoutofport,severaladultpassengersexperiencesuddenonsetofnauseaandabdominalcramps,followedbyperiodsofwaterydiarrhea.Someoftheaffectedpassengersalsoexperiencevomiting,andmosthaveheadaches,myalgias,orabdominalpain.StoolsmearsshownoRBCs,leukocytes,ova,orcysts.Theaffectedpassengersrecoverwithouttherapyoverthenext3days.Whichofthefollowingisthemostlikelycausativeagent?ANorovirusBRotavirusCShigelladysenteriaeDYersiniapseudotuberculosisEVibrioparahaemolyticus第17题Acutehemorrhagicconjunctivitis(AHC)isacontagiousocularinfectioncharacterizedbypain,swellingoftheeyelids,andsubconjunctivalhemorrhages.AHChasbeenreportedtobecausedbywhichofthefollowingviruses?ACoronavirusBReovirusCRhinovirusDEnterovirusERespiratorysyncytialvirusHIVQuiz第1题Whichofthefollowingviruscontainsreversetranscriptaseenzyme?AEBvirusBHumanimmunodeficiencyvirusCHerpessimplexvirusDSARS-CoV-2EInfluenzavirus第2题TheglycoproteinofHIV,gp120

Acausesmembranefusion.Bbindstotheviralreceptoronthecellsurface.Cishighlyconservedamongdifferentisolates.Dfailstoelicitneutralizingantibody.Einduceschemokineproduction.第3题WhichofthefollowingisthemaintargetcellofHIV?ACD8+cellsBEpithelialcellsCCTLDNKcellsECD4+cells正确答案：E第4题HIVcontainskindsofproteins,whichoneoffollowinggeneratetheneutralizingantibody?Agp120Bgp41CP24DP17EP7第5题WhichofthefollowingisnotthemechanismsofHIVcytopathogenesis?ACTLsmediated-cytolysisBAlterationofcellmembraneCAppearanceofinclusionbodiesDVirusinduced-apoptosisESyncytiaformation第6题TodesignavaccineagainstHIVinfection,ifyouwishedtopreventthefusionofHIVtothehostcells,whichmoleculemightbestbetargeted?Agp120Bgp41Cp17Dp24Ep9第7题TheattachmentofHIVisinitiatedbythebindingoftheHIVgp120moleculestothereceptorsonthetargetcells.Thengp120undergoesaconformationalchangeandbindstoasecondmolecule.WhatarethemoleculesonthesurfaceoftheinfectedcellsthatactasreceptorsandbindwiththelymphotropicHIV?ACD4andCCR5expressedonmacrophagesBCD4andCXCR4expressedondendriticcellsCCD4andCXCR4expressedonTcellsDCD41andCCR5expressedonBcellsECD41andCCR5expressedonTcells第8题Thereisusuallyalongperiod(clinicallatency)betweenthetimeofprimaryHIVinfectionandthedevelopmentofAIDSinatypicalcourseofanuntreatedHIVinfection.Duringthisperiodofclinicallatency,ACD4cellcountsremainunchanged.BViruscannotbetransmittedtoothers.CHIVisnotdetectableintheplasma.DNeutralizingantibodiesarenotelicited.EVirusispresentinlymphoidorgans.正确答案：E第9题AdoctorsufferedaneedlestickwithbloodfromanHIV-positivepatient.HeisconcernedthathemaybeinfectedwithHIV.Samplesaretakenfromthedoctoramonthlaterforanalysis.Whatassayswouldbeappropriatetodeterminewhetherthemanisinfectedwiththevirus?ACD4+cellcountBCD4:CD8cellratioCDegreeoflymphadenopathyDHIVRNAEAnti-HIVantibody第10题WhichtestisthemostusedconfirmativetestofHIVpresence?AELISATestBWesternBlotCOralFluidTestDUrineroutinedetectionEVirusisolation第11题WhichofthefollowingindividualsmaybeatincreasedriskofacquiringanHIVinfection?AAgrandmotherlivinginthesamehouseholdwitharelativewhoisHIV-positiveBAtouristinhistripwithmultiplesexpartners.CAreceptionistatanAIDSclinicinahospital.DAteacherwithanHIV-positivechildinherclassroom.EAbaseballplayerwhoseteammateisHIV-positive.第12题PotentiallyinfectiousfluidsinapersonwithHIVinfectionincludeallofthefollowingexceptABloodBSalivavisiblycontaminatedwithbloodCGenitalsecretionsDAmnioticfluidEUrinenotvisiblycontaminatedwithblood正确答案：E第13题OneofthebiggestproblemencounteredintheHIV/AIDSvaccinestudiesisATheviruscouldnotbecultivated.BThereisnoanimalmodel.CTherearelotsofsubtypesofHIV.DThestructureofHIVistoocomplex.EHighvariabilityofglycoproteinofvirusenvelope.正确答案：E第14题Highlyactiveantiretroviraltherapy(HAART)becameavailablefortreatmentofHIVinfection,utilizingvariousclassesofdrugtargetingvariousreplicationcyclesteps.Whichofthefollowingisoneofthetargetsforantiviralagents?AmembranesynthesisBgp120formationCp24antibodyexpressionDReversetranscriptaseEDNase第15题ThecommonopportunisticinfectionsoccurinAIDSpatientsexceptAInfectionoftoxoplasmaBInfectionofClostridiumdifficileCInfectionofMycobacteriumtuberculosisDInfectionofCryptococcusneoformansEInfectionofCytomegalovirusHerpesVirusesQuiz第1题A55-year-oldmandevelopedsomefluid-filledblistersonandaroundhislipsafterhegotfeveradayago.Whichofthefollowingvirusesisthemostlikelyagentcausinghiscondition?AHerpessimplexvirusBCytomegalovirusCVericella-zostervirusDMeaslesvirusEMumpsvirus第2题Atypicallymphocytosisismostlikelytobefoundinwhichoneofthefollowingdiseases?AEncephalitiscausedbyherpessimplexvirus(HSV)BMononucleosisinducedbyEpstein-BarrvirusCParvovirusinfectionDChronichepatitisCERotavirusgastroenteritis第3题WhichoneofthefollowingwouldbethetreatmentofchoiceforHSVinfection?AAcyclovirBKilledvirusvaccineCHerpesimmuneglobulinDAzythromycinERecombinantviralvaccine第4题Whatisthemostappropriatespecimenforthedetectionofavaricella-zostervirus(VZV)?ACervicaltissueBSynovialfluidCBloodDSkinECerebrospinalfluid第5题A28-year-oldpregnantwomanpresentsneartermwithlesionssuspiciousforprimarygenitalherpes.CultureidentifiesthepresenceofHSV-2.Atthetimeofdeliveryshestillhasactivegenitallesions.Whichofthefollowingshouldbedonetoavoidtransmittingthevirustothebaby?ACesareandeliveryBInternalfetalmonitoringCRuptureofthemembranestospeeddeliveryDVaginaldelivery第6题Allofthefollowingdiseasesareclassicalchildhoodexanthems(rash)exceptAVaricellaBRubellaCDengueDRoseolaEMeasles第7题Whichofthefollowingvirusescanbelatentinneurons?AEBVBHAVCHSVDCMVEHBVHepatitisVirusesQuiz第1题HDVisadefectivevirusthatcanreplicateonlyincellsalreadyinfectedwithwhichofthefollowingviruses?AHepatitisAvirusBEpstein-BarrvirusCHepatitisGvirusDHepatitisBvirusEHIV第2题WhichofthefollowingmarkersisusuallythefirstviralmarkerdetectedafterhepatitisBinfection?AHBeAgBHBsAgCHBcAgDAnti-HBcEAnti-HBe第3题WhichofthefollowingmarkersiscloselyassociatedwithHBVinfectionandDNApolymeraseactivity?AHBeAgBHBsAgCHBcAgDAnti-HBsEAnti-HBe第4题Whichofthefollowingisfoundwithinthenucleiofinfected

livercellsandnotusuallyintheperipheralcirculation?AHBeAgBHBsAgCHBcAgDAnti-HBcEAnti-HBe第5题IgMantibodytotheviralparticleisthemethodofchoiceforlaboratorydiagnosisofwhichoneofthefollowinghepatitisviruses?AHepatitisABHepatitisBCHepatitisCDHepatitisDEHepatitisE第6题Vaccinationforthishepaticdiseaseiswithviralsurfaceantigenandusuallyprovidesimmunity.AHepatitisABHepatitisBCHepatitisCDHepatitisDEHepatitisE第7题Thishepatitisvirusisacalicivirus.Thereservoirisinpigs,andhumansacquireitviathefecal-oralroute.AHepatitisABHepatitisBCHepatitisCDHepatitisDEHepatitisE正确答案：E第8题A25-year-oldresidentisfoundtobebothHBsAg-positiveandHBeAg-positive.TheresidentmostlikelyAhashepatitisBandisinfectiousBhasbothHBVandHEVinfectionsChasachronicHEVinfectionsDhasclearedapastHBVinfectionEwaspreviouslyimmunizedwithHBVvaccinepreparedfromhealthyHBsAg-positivecarriers第9题A50-year-oldwomanisadmittedtothehospitalbecauseofjaundice.ThensheisfoundtohavehepatitisCvirusinfection.ThemajorriskfactorforHCVinfectionisATattoosBInjectingdruguseCBloodtransfusionDSexualactivityEWorkinginhealthcareoccupations第10题Severaldifferentvirusescancausehepatitis.Oneofthefollowingstatementsappliestoallfourviruses:HAV,HCV,HDV,andHEV.Aistransmittedprimarilybythefecal-oral-routeBistransmittedprimarilybytherespiratoryrouteCcontainsasingle-strandedRNAgenomeDisassociatedwithfulminanthepatitisEundergoessequencevariationduringchronicinfectionOtherImportantHumanVirusesQuiz第1题AllofthefollowingarevectorsofarbovirusesexceptAAedesBCulexCTicksDRodentsEMites第2题AllthefollowingvirusesareinthesamefamilywithDenguevirusexceptAJapaneseEncephalitisvirusBEasternequineencephalitisvirusCRussianspring-summerencephalitisvirusDYellowfevervirusEWestNilevirus第3题TheNaturalhost/sofDenguevirusis/areAMonkeyBHumanCMosquitoesDMonkeyandhumanEMonkey,humanandmosquitoes第4题Hantaviruses,whichcancauseHFRS,canbedescribedbywhichofthefollowing?ATheyarearenavirusesBTheyarereadilytransmittedhuman-to-humanCTheycauseinfluenza-likesymptomsfollowedrapidlybyacutegastroenteritisDTheyareacquiredbyinhalationofaerosolsofmouseurineandfecesETheynevershowantigenicvariation第5题Allofthefollowingviralfamilieshave-ssRNAgenomesexceptAArenaviridaeBBunyaviridaeCFiloviridaeDFlaviviridae第6题ThereservoirforhantaanvirusisAStripedfieldmouseBBrownratCNorwayratDDeerrat第7题ThechemicalcompositionofprionisAnucleicacid,proteinBnucleicacid,lipidCnucleicacidDProteinELipid第8题A40-yearoldwomanisunablerememberwhereshelivedorevenherphone.Shepresentsdisorientedandconfused.Sheisadmittedforobservationandtestingandbeginstohallucinateandsalivateexcessively.Thewomanhadbeenbittenbyaraccon.Whichofthefollowingisthemostlikelycause?AMeaslesBPrionCRabiesvirusDHIVEPoliovirus第9题ThepresenceofNegribodiesinthecytoplasmofhippocampalneuronsmayassistinthediagnosisofAencephalitisBvirusinfectionBrabiesvirusinfectionCforestencephalitisvirusinfectionDherpesvirusinfectionEP