Fomepizole-d2-4-Methylpyrazole-d-sub-2-sub-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEFomepizole-d2Cat.No.:HY-W724345Synonyms:4-Methylpyrazole-d2分⼦式:C₄H₄D₂N₂分⼦量:84.12作⽤靶点:Isotope-LabeledCompounds;CytochromeP450作⽤通路:Others;MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Fomepizole-d2(4-Methylpyrazole-d2)氘代标记的Fomepizole(HY-B0876)。Fomepizole(4-Methylpyrazole)⼀种有效的细胞⾊素P450(CYP2E1)抑制剂。Fomepizole竞争性的⼄醇脱氢酶(alcoholdehydrogenase)抑制剂。Fomepizole可以阻⽌甲醇和⼄⼆醇进⼀步转化为有毒代谢产物。Fomepizole有潜⼒⽤作⼄⼆醇或甲醇中毒的解毒剂。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].CasavantMJ.Fomepizoleinthetreatmentofpoisoning.Pediatrics.2001Jan;107(1):170.[2].LepikKJ,etal.Adversedrugeventsassociatedwiththeantidotesformethanolandethyleneglycolpoisoning:acomparisonofethanolandfomepizole.AnnEmergMed.2009Apr;53(4):439-450.e10.[3].GarrettRampon,etal.Useoffomepizoleasanadjunctinthetreatmentofacetaminophenoverdose:acaseseries.ToxicologyCommunications.Volume4,2020-Issue1.[4].PáezAM,etal.Effectsof4-methylpyrazoleonethanolneurobehavioraltoxicityinCD-1mice.AcadEmergMed.2004Aug;11(8):820-6.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>