GEA-3162-hydrochloride-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEGEA3162hydrochlorideCat.No.:HY-120314A分⼦式:C₇H₅Cl₃N₄O分⼦量:267.5作⽤靶点:Apoptosis;Caspase;EndogenousMetabolite作⽤通路:Apoptosis;MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性GEA3162hydrochloride⼀种⼝服有效的NO/ONOO供体的化合物。GEA3162hydrochloride通过cGMP途径显著抑制⼈多形核⽩细胞(PMNs)的活化，抑制炎症介质释放，发挥抗炎和保护作⽤。GEA3162hydrochloride通过ONOO途径、激活caspase-2/3/8/9，诱导中性粒细胞和⾻髓细胞凋亡(apoptosis)。GEA3162hydrochloride在⼤⿏胃溃疡模型中具有双向作⽤：低剂量时显著减轻胃黏膜损伤，⽽⾼剂量时加重溃疡积。GEA3162hydrochloride可⽤于研究胃溃疡等炎症。IC50&TargetCaspase-2Caspase-3Caspase-8Caspase-9REFERENCES[1].MoilanenE,etal.Inhibitionbynitricoxide-donorsofhumanpolymorphonuclearleucocytefunctions.BrJPharmacol.1993;109(3):852-858.[2].TaylorEL,etal.GEA3162hydrochloridedecomposestoco-generatenitricoxideandsuperoxideandinducesapoptosisinhumanneutrophilsviaaperoxynitrite-dependentmechanism.BrJPharmacol.2004Sep;143(1):179-85.[3].TaylorEL,etal.GEA3162,aperoxynitritedonor,inducesBcl-2-sensitive,p53-independentapoptosisinmurinebonemarrowcells.BiochemPharmacol.2007Oct1;74(7):1039-49[4].AsmawiMZ,MoilanenE,AnnalaK,RahkonenP,KankaanrantaH.EffectsofnitricoxidedonorsGEA3162andSIN-1onethanol-inducedgastriculcerationinrats.EurJPharmacol.1999Jul28;378(1):123-7.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792