LY-345899-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemELY345899(Standard)Cat.No.:HY-101943RCASNo.:10538-99-5分⼦式:C₂₀H₂₁N₇O₇分⼦量:471.42作⽤靶点:ReferenceStandards;MethylenetetrahydrofolateDehydrogenase(MTHFD)作⽤通路:Others;MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性LY345899(Standard)LY345899(HY-101943)的分析标准品。本产品⽤于研究及分析应⽤。LY345899是⼀种叶酸的类似物，也⼀种亚甲四氢叶酸脱氢酶(MTHFD1;DC301)和MTHFD2抑制剂，其IC50值分别为96nM和663nM，对MTHFD1的Ki值为18nM。IC50&TargetKi:18nM(MTHFD1)[1];IC50:96nM(MTHFD1)and663nM(MTHFD2)[3]REFERENCES[1].SchmidtA,etal.Structuresofthreeinhibitorcomplexesprovideinsightintothereactionmechanismofthehumanmethylenetetrahydrofolatedehydrogenase/cyclohydrolase.Biochemistry.2000May30;39(21):6325-35.[2].TedeschiPM,etal.MitochondrialMethylenetetrahydrofolateDehydrogenase(MTHFD2)OverexpressionIsAssociatedwithTumorCellProliferationandIsaNovelTargetforDrugDevelopment.MolCancerRes.2015Oct;13(10):1361-6.[3].GustafssonR,etal.CrystalStructureoftheEmergingCancerTargetMTHFD2inComplexwithaSubstrate-BasedInhibitor.CancerRes.2017Feb15;77(4):937-948.[4].Huai-QiangJu,etal.ModulationofRedoxHomeostasisbyInhibitionofMTHFD2inColorectalCancer:MechanismsandTherapeuticImplications.JNatlCancerInst.2019Jun1;111(6):584-596.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792