3-3-Dihydroxy-2-6-bis-4-hydroxybenzyl-5-methoxybibenzyl-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemE3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzylCat.No.:HY-N17845CASNo.:87530-27-6分子式:C₂₉H₂₈O₅分子量:456.53作用靶点:Microtubule/Tubulin作用通路:CellCycle/DNADamage;Cytoskeleton储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl是一种茋类化合物，为微管蛋白(tubulin)抑制剂，其IC50为10μM。3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl可抑制微管蛋白聚合。3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl可作为增强剂，增强SN-38(HY-13704)在BCRP转导的癌细胞中的细胞毒性。3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl可用于乳腺癌的研究[1]。体外研究3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl(compound4)(10μM)inhibitspurifiedtubulinproteinpolymerizationwithanIC50of10μM[1].3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl(compound4)(3μM;5days)reversesBCRP-mediatedSN-38resistanceinK562/BCRPcellswithareversalindexof3.0[1].REFERENCESMoritaH,etal.Antimitoticactivityandreversalofbreastcancerresistanceprotein-mediateddrugresistancebystilbenoidsfromBletillastriata.BioorgMedChemLett.2005;15(4):1051-1054.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:021-53