3-O-Debenzoylzeylenone-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE3-O-DebenzoylzeylenoneCat.No.:HY-N13800CASNo.:1800008-77-8分⼦式:C₁₄H₁₄O₆分⼦量:278.26作⽤靶点:Phytohormone作⽤通路:Others储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性3-O-Debenzoylzeylenone⼀种多氧取代环⼰烯类植物⽣长激素，存在于紫⽟盘(Uvariapurpurea)的叶⽚和⼤花紫⽟盘(Uvariagrandiflora)的地上部分中。3-O-Debenzoylzeylenone⼀种植物⽣长素类似物，可抑制⽣菜(Lactucasativa)根⽣长、促进⽣菜幼地上部分⽣长。3-O-Debenzoylzeylenone对多种癌细胞具有细胞毒性，可⽤于肺癌、⿊⾊素瘤、表⽪样癌、肝癌、胃癌、结肠腺癌、急性⽩⾎病、乳腺癌、前列腺癌的相关研究[1][2]。体外研究3-O-Debenzoylzeylenone(50ppm;5days)inhibitsrootgrowthoflettuce(Lactucasativa)byupto64.5%andpromotesitsstemgrowthbyupto19.6%[1].3-O-Debenzoylzeylenone(compound1)exhibitssignificantcytotoxicityagainsttheLU-1andSK-Mel-2celllines(withIC50valuesof4.68and3.63μM,respectively),showsmoderatecytotoxicityagainstavarietyofothercancercelllines,anddisplaysonlyweaktoextremelyweakcytotoxicityagainsttheMDA-BA-231,LNCaPandnormal3T3celllines[2].CellViabilityAssayWesternBlotAnalysisCellProliferationAssayApoptosisAnalysisCellCytotoxicityAssayCellCycleAnalysisRT-PCRCellAutophagyAssayImmunofluorescenceCellDifferentiationAssayCellInvasionAssayCellMigrationAssayRealTimeqPCRELISAAssay[2]CellLine:LU-1(humanlungcancer),KB(epidermoidcarcinoma),MDA-BA-231(highmetastasishumanbreastcancer),LNCaP(humanprostatecancer),Hep-G2(humanhepatomacancer),MKN-7(stomachcancer),SW-480(humancolonadenocarcinoma),HL-60(humanacuteleukemia),SK-Mel-2(melanomacarcinoma),3T3(normalcell)Concentration:IC501/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEIncubationTime:/Result:InhibitedcellgrowthwithIC50sof4.68μM(LU-1),13.35μM(KB),64.06μM(MDA-MB-231),45.43μM(LNCaP),13.13μM(Hep-G2),8.63μM(MKN-7),11.26μM(SW-480),6.22μM(HL-60),3.63μM(SK-Mel-2),25.86μM(3T3),respectively.REFERENCES[1].TakeuchiY,etal.PolyoxygenatedcyclohexenesfromtheChinesetree,Uvariapurpurea.BiosciBiotechnolBiochem.2002;66(3):537-542.[2].HoDV,etal.AnewpolyoxygenatedcyclohexeneandanewmegastigmaneglycosidefromUvariagrandiflora.BioorgMedChemLett.2015;25(16):3246-3250.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearch