控制昼夜节律的分子机制

1、First, two questions.,When do you get up? When do you go to bed?,The biological clock is warning you,The molecular mechanism of controlling circadian rhythm 控制昼夜节律的分子机制,Reporter： Zhang Qing 2018.06.06,The sunset but the rest. （日落而息）,The sunrise makes. (日出而作),A phenomenon of the circadian rhythm / th

2、e biological clock,HOW DOES IT WORK IN GENE?,The fruit fly : sleeps during the day howls during the night,WHY?,The mutation(缺失) of a period gene in the body,周期基因,How to Realize Regulation of Circadian Rhythm precisly? 如何实现昼夜节律的精确调控?,What Is the Period Gene ?,The period gene encodes a protein called

3、PER. The timeless gene encodes a protein called TIM. The double-time gene encodes a protein called DBT.,The PER protein will be transferred from the cytoplasm(细胞质) to the nucleus with the help of TIM protein at night. The PER protein will degrade（降解） during the day. The process of accumulation and d

4、egradation is about 24 hours, which corresponds to peoples day and night. DBT is to slow down the accumulation（积累） of PER protein, which allows precise regulation of circadian rhythms.,Open the lock requires two keys, one called the PER protein and the other called a TIM. The frequency(频率) of openin

5、g the door is controlled by the DBT protein.,The process is liked as a lock and a key,First, heal some of the genetic diseases（遗传性疾病）. Second, cure insomnia(失眠). Third, reveal the danger of staying up late.,What is The Use of This Finding?,At last but not at least, we must let the body rest at the rig