高血压英文ppt精品课件blood

Blood Vessels Frank A. Acevedo, PA-C Vascular Abnormalities Narrowing of the lumen Thrombosis Weakening of the walls Normal Intima - Endothelial Cells Media - Smooth Muscle Cells Adventitia - Connective Tissue Arteries Elastic arteries Muscular arteries Arterioles Endothelium Anticoagulant/Antithrombotic prostacyclin, thrombomodulin, plasminogen activator, heparin-like molecules Prothrombotic VonWillebrand Factor, tissue factor, plasminogen activator inhibitor Vascular Smooth Muscle Vasoconstriction Dilatation Collagen, elastin synthesis Cellular proliferation in atherosclerosis Vascular Diseases Congenital anomalies Atherosclerosis Hypertensive vascular disease The vasculitides Raynauds disease Aneurysms Vascular tumors Congenital Anomalies Berry aneurysms AV fistulas Atherosclerosis Elastic and medium sized arteries Atheroma is the basic lesion Age, male, genetic LDL, VLDL Monocytes - macrophages - foam cells Endothelial injury Atherosclerosis Atherosclerosis Atherosclerosis Atherosclerosis Risk Factors Major diet and hyperlipidemia, hypertension, cigarette smoking, diabetes Minor obesity, lack of exercise, age, male, family history, stress, BCP, High CHO intake, hyperhomocysteinemia Hypertension Idiopathic, essential Renin - Angiotensin Accelerated atherogenesis Hyaline atherosclerosis Vasculitides Giant cell arteritis Takayasus arteritis Polyarteritis nodosa Kawasaki disease Wegeners granulomatosis Buergers disease Giant Cell Arteritis Rare before age 50 Throbbing pain Visual disturbances Temporal artery Corticosteroids Polymyalgia rheumatica Giant Cell Arteritis Giant Cell Arteritis Takayasus Arteritis Fibrous thickening of aortic arch Upper extremity pulselessness Females 15 - 40 Polyarteritis Nodosa Systemic involvement Fever, weight loss, hypertension Abdominal pain Melena Muscle aches Motor peripheral neuropathy Polyarteritis Nodosa Kawasaki Syndrome Young children and infants Fever, conjunctival and oral erythema and erosion, edema of the hands and feet, erythema of the palms and soles, desquamation, lymph node enlargement Leading cause of acquired heart disease in children Wegeners Granulomatosis Acute necrotizing granulomas of the upper and lower reap tract Focal necrotizing vasculitis Renal disease 5th decade of life Immunosuppressive therapy Wegeners Granulomatosis Buergers Disease Thromboangitis obliterans Cigarette smoking “instep” claudication Buergers Disease Buergers Disease Buergers Disease Raynauds Disease Small artery, arteriole vasospasm White, blue, red Raynauds Disease Raynauds Disease Aneurysms Abdominal aorta frequently affected Natural history is to rupture Ischemic intima and media? Male caucasians Early detection Dissection Type A Type B Hypertension Double lumen DeBakey Classification Dissection V