人卫版药理学抗高血压药ppt课件.ppt

Chapter 23,Antihypertensive Drugs 抗高血压药,1,【目的要求】,1、掌握第一线抗高血压药物的降压机制、临床应用、主要不良反应。 2、熟悉抗高血压药物的分类；熟悉高血压药物治疗的新概念。 3、了解其他经典抗高血压药物。,2,3,4,Pathophysiologic mechanisms of hypertension,5,Antihypertensive drug,Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction.,6,Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischaemic heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. There are many classes of antihypertensives, which lower blood pressure by different means; among the most important and most widely used are the thiazide diuretics, the ACE inhibitors, the calcium channel blockers, the beta blockers, and the angiotensin II receptor antagonists or ARBs.,7,Contents,1 Diuretics 2 Adrenergic receptor antagonists 3 Thiazides 4 Calcium channel blockers 5 Renin Inhibitors 6 ACE inhibitors 7 Angiotensin II receptor antagonists 8 Aldosterone receptor antagonists 9 Vasodilators 10 2 agonists 11 Endothelin receptor blockers,8,2010 年中国高血压防治指南要点,1. 我国人群高血压患病率仍呈增长态势，每5 个成人中就有1 人患高血压；估计目前全国高血压患者至少2 亿；但高血压知晓率、治疗率和控制率较低。 2高血压是我国人群脑卒中及冠心病发病及死亡的主要危险因素。控制高血压可遏制心脑血管疾病发病及死亡的增长态势。 3我国是脑卒中高发区。高血压的主要并发症是脑卒中，控制高血压是预防脑卒中的关键。 4