CD-白细胞分化抗原-细胞膜表面分化抗原群的定义及意义.docx

CD/白细胞分化抗原/细胞膜表面分化抗原群的定义及意义 CD（Cluster of differentiation）就是细胞膜表面的分化抗原群/分化抗原簇，应用聚类分析，可将来自不同实验室识别同一分化抗原的单克隆抗体归为一个CD，经由从1982年第1次国际上人类白细胞分化抗原会议（The Human Leucocyte Differentiation Antigen workshop，HLDA） 统一命名。迄今为至，人CD的序号已从CD1命名至CD350 (2009年)，可大致划分为T细胞、B细胞、髓细胞、NK细胞、血小板、粘附分子、内皮细胞、细胞因子受体、激活抗原、碳水化合物半抗原、树突状细胞、干细胞祖细胞、基质细胞和红细胞14个组。白细胞分化抗原（Leucocyte Differentiation Antigen，LDA）是指不同谱系(1ineage)血细胞在正常分化，成熟，活化过程中出现或消失的细胞表面标志，多是跨膜蛋白或糖蛋白，少数为碳水化合物半抗原。随着人类功能基因组计划研究以及免疫学与其他学科的交叉，人类白细胞分化抗原的概念逐渐被人类细胞分化分子(HCDM)所替代。 采用单克隆抗体鉴定方法识别的白细胞分化抗原又称CD （cluster of differentiation） 抗原。 检测CD 抗原是实验室识别细胞及不同分化阶段细胞或细胞亚群最主要的方法。白细胞分化抗原（狭义上的CD）参与机体重要的生理和病理过程：免疫应答过程中免疫细胞的相互识别，免疫细胞抗原识别、活化、增殖和分化，免疫效应功能的发挥；造血细胞的分化和造血过程的调控；参与炎症反应、血栓形成和组织修复；参与细胞的生长、分化、迁移，及肿瘤的恶化和转移。 CD在基础免疫学研究中主要应用于：CD抗原的基因克隆，新CD抗原及新配体的发现；CD抗原结构与功能关系；细胞激活途径和膜信号的传导；细胞分化过程中的调控；细胞亚群的功能。CD在临床免疫学研究中主要用于：机体免疫功能的检测；白血病、淋巴瘤免疫分型；免疫毒素用于肿瘤治疗、骨髓移植以及移植排斥反应的防治；体内免疫调节治疗。 在许多场合下，抗体及其识别的相应抗原都用同一个CD序号，因此在参阅教科书和文献时需加注意：(1)CD是流水编号，CD129暂缺；CD67和CD66b是重复的；CD187-190，CD211，CD237，CD341-343，CD345-248暂未编号。(2)CD中带有w的抗原或抗体CDw12，CDw198，CDw199，CDw293尚需继续进行全面鉴定。(3)有些CD抗原又可进一步划分为不同的成员，一般用小写英文字母表示，但情况有所不同：如CD1可分为CD1a，CD1b和CD1c，这三种不同分子是分别由三个不同的高度同源的基因所编码；CD45至少可分为CD45RA，CD45RB，CD45RC和CD45RO，它们是同一基因的不同异型/同种型（isoform）；CD2和CD2R是识别同一个分子上不同的表位；CD49已进一步划分为CD49a，D49b，CD49c，CD49d，CD49e和CD49f，它们的基因定位于不同的染色体上，但具有较高的同源性。（4）CD的组划分的特异性是相对的，实际上，许多CD抗原的组织细胞分布较为广泛。此外，有的CD抗原可由不同的分类角度而归入不同的组，如IL-2受体a链CD25是活化T细胞的标记，也属于细胞因子受体；再如某些属于T细胞、B细胞、髓细胞或NK细胞组的CD抗原实际上也是粘附分子，等等。CD 主要抗原表达(Main Antigen Expression)/其他名字/分子量(kDa)CD1a Cortical Thymocytes (stg), B cell subset, Dendritic cells, Langerhans cells 49,12CD1b Cortical Thymocytes (mod), B cell subset, Dendritic cells, Langerhans cells 45,12CD1c Cortical Thymocytes (weak), B cell subset, Dendritic cells, Langerhans cells 43,12CD2 T cells, NK cells LFA-2, E-Rosette Receptor 50CD2R Activated T cells 50CD3 T cells 16,20,25-28CD4 Helper-inducer T cells, Monocytes, Macrophages 56CD5 T cells, B cell subset 67CD6 T cells, B cell subset 105CD7 T cells 40CD8 Cytotoxic/Suppressor T cells, NK cells 32-34CD9 Platelets, Monocytes, Pre-B cells 24CD10 Pre-B cells, Granulocytes CALLA 100CD11a Leukocytes LFA-1, L Integrin 180CD11b Granulocytes, Monocytes, NK cells MAC-1, M Integrin, CR3 170CD11c Granulocytes, Monocytes, NK cells, T cell subset, B cell subset, X Integrin 150CDw12 Granulocytes, Monocytes 90-120CD13 Granulocytes, Monocytes Aminopeptidase N 130CD14 Monocytes 55CD15 Granulocytes, Monocytes Lewis X CHOCD15s Neutrophils Sialyl Lewis X CHOCD15u Myeloid subset Sulfated Lewis X CHOCD16a NK cells, Macrophages FcRIII A 50-65CD16b Granulocytes FcRIII B 48CD17 Granulocytes, Monocytes, Platelets Lactosylceramide -CD18 Leukocytes (Platelets negative) 2 Integrin 95CD19 B cells 90CD20 B cells 33,35,37CD21 B cells subset, Follicular dendritic cells CR2 145CD22 B cells 140CD23 B cell subset, Eosinophils, Platelets FcRII 50-45CD24 B cells, Granulocytes 41/38CD25 Activated T cells IL-2R Chain 55CD26 T cell subset, Macrophages 110CD27 T cell subset 55CD28 T cell subset 44CD29 Leukocytes 1 Integrin 130CD30 Activated T and B cells, Reed Sternberg cells Ki-1 105CD31 Platelets, Monocytes, Granulocytes, B cells PECAM-1, GPIIa 140CD32 Monocytes, Neutrophils, B cells, Eosinophils FcRII 40CD33 Myeloid Progenitor cells, Monocytes 67CD34 Hematopoietic Progenitor cells 105-120CD35 Monocytes, B cells, Granulocytes CR1 160,190,220,250CD36 Monocytes, Platelets GPIV (IIIb) 88CD37 B cells 52-40CD38 Activated T cells, Plasma cells 45CD39 B cells, Monocytes 100-70CD40 B cells, Monocytes, Carcinoma cells 48/44CD41 Platelets, Megakaryocytes GPIIb/IIIa, IIb Integrin 120CD42a Platelets, Megakaryocytes GPIX 23CD42b Platelets, Megakaryocytes GPIB-a 135,23CD42c Platelets, Megakaryocytes GPIB-b 22CD42d Platelets, Megakaryocytes GPV 85CD43 T cells, Granulocytes, Monocytes Leukosialin 90-100CD44 Leukocytes, Erythrocytes H-CAM, Pgp-1 8-90CD44R (Varied-dependent upon Exon Splicing)CD45 Leukocytes Leukocyte Common Antigen 180,190,205,220CD45RA B cells, T cell subset, Monocytes 220,205CD45RB B cells, T cell subset, Monocytes 190,205,220CD45RC B cells, T cell subset 190,205,220CD45RO B cells, T cell subset, Monocytes 180CD46 Ubiquitous (Erythrocytes negative) Membrane Cofactor Protein 66,56CD47 Ubiquitous 47-52CD47R Broad 47-52CD48 Leukocytes 43CD49a Activated T cells VLA-1, 1 Integrin 210CD49b B cells, Monocytes, Platelets VLA-2, 2 Integrin 160CD49c B cells VLA-3, 3 Integrin 125CD49d Lymphocytes, Monocytes, Eosinophils VLA-4, 4 Integrin 150,80,70CD49e T cell subset, Monocytes, Platelets VLA-5, 5 Integrin 132/25CD49f T cell subset, Monocytes VLA-6, 6 Integrin 120/25CD50 Leukocytes ICAM-3 124CD51 Platelets V Integrin 125/25CD51/61 Platelets, Osteoclasts, Endothelial cells complexCD52 Leukocytes CAMPATH-1 21-28CD53 Leukocytes 32-40CD54 Endothelial cells, Various activated cells ICAM-1 90CD55 Broad Decay Accelerating Factor 75CD56 NK cells N-CAM 220/135CD57 NK cells, T cell subset HNK-1 110CD58 Broad LFA-3 65-70CD59 Broad Protectin, Homologous Restriction Factor 18-20CD60a T cell subset, platelets GD3 CHOCD60b T cell subset, activated B cells 9-0-sialyl GD3 CHOCD60c T cell subset 7-0-sialyl GD3 CHOCD61 Platelets, Megakaryocytes 3 Integrin, GPIIIa 110CD62E Endothelial cells E-Selectin, ELAM-1 140CD62L Lymphocytes, Monocytes, NK cells L-Selectin, LECAM-1 150CD62P Activated Platelets, Endothelial cells P-Selectin, LECAM-3 75-80CD63 Activated Platelets, Monocytes 53CD64 Monocytes FcRI 75CD65 NeutrophilsCD65s Neutrophils, MonocytesCD66a Neutrophils Biliary Glycoprotein 160-180CD66b Granulocytes CGM6 95-100CD66c Neutrophils, Colon carcinoma NCA 90CD66d Neutrophils CGM1 30CD66e Colon epithelial CEA 180-200CD66f Pregnancy Specific GlycoproteinCD67 (Re-assigned to CD66b) (重复CD66b)CD68 Monocytes, Macrophages 110CD69 Activated T and B cells, NK cells Activation Inducer Molecule 34/28CD70 Activated T and B cells, Reed-Sternberg cells 75,95,170CD71 Proliferating cells Transferrin Receptor 95CD72 B cells 43/39CD73 B & T cell subset ECTO-5 Nucleotidase 69CD74 B cells, Monocytes Invariant Chain 41,35,33CD75 B cell subset, Epithelial Lactosamines CHOCD75s B cell subset -2, 6-sialylated Lactosamines CHOCD77 Activated B cells, Endothelial cellsCD79a B cells MB-1 33,40CD79b B cells B29 33,40CD80 Activated B cells B7-1 60CD81 B cells, T cells, Neutrophils TAPA-1 22CD82 Leukocytes, Platelets 50-53CD83 Dendritic cells, Activated lymphocytes HB15 43CD84 Monocytes, Platelets, B cells 73CD85 Dendritic cells, Monocytes, B cells see note 1 in notes section 110CD86 Monocytes, Activated B cells B7-2 80CD87 Granulocytes, Monocytes, Activated T cells UPA Receptor 50-65CD88 Granulocytes C5a Receptor 42CD89 Neutrophils, Monocytes Fc Receptor 55-70CD90 Progenitor cell subset, Thymic Stromal cells THY-1 18CD91 Monocytes 2 Macroglobulin Receptor 600CD92 Neutrophils, Monocytes, Platelets, Endothelial cells 70CD93 Neutrophils, Monocytes, Endothelial cells 120CD94 NK cells, T cell subset 30CD95 Apoptotic cells FAS 42CD96 Activated T cells Tactile 160CD97 Activated T cells CD55 Ligand 74,80,89CD98 Monocytes, T cells, B cells 4F2 80,40CD99 Lymphocytes, Thymocytes 32CD99R T cells, NK cells, Myeloid cells 32CD100 Broad 150CD101 Granulocytes, Monocytes, Activated T cells 140CD102 Lymphocytes, Monocytes ICAM-2 60CD103 Intra Epithelial Lymphocytes HML-1, E Integrin 150,25CD104 Epithelial, Schwann cells 4 Integrin 220CD105 Endothelial cells Endoglin 95CD106 Activated Endothelial cells VCAM-1 100-110CD107a Activated Platelets LAMP-1 110CD107b Activated Platelets LAMP-2 120CD108 Activated splenic T cells 80CD109 Activated T cells, Platelets, Endothelial cells Platelet Activation Factor 170/150CD110Stem cell subset,Megakaryocytes,Platelets (v. weak) Thrombopoietin Receptor, Mpl 82-84CD111 Stem cell subset, Macrophages, Neutrophils PRR/Nectin-1 64-72CD112 Monocytes, Neutrophils, Stem cell subset PRR2/Nectin-2 64-72CD113 Epithelial cells, Placenta PRR3, Nectin-3 83CD114 Granulocytes, Monocytes G-CSF Receptor 95,139CD115 Monocytes, Macrophages M-CSF Receptor 150CD116 Monocytes, Neutrophils, Eosinophils GM-CSF Receptor Chain 60CD117 Progenitor cells SCF-Receptor, c-kit 145CD118 Epithelial cells LIF Receptor 190CD119 Monocytes, B cells, Epithelial cells IFN Receptor 90CD120a Monocytes, Granulocytes TNF Receptor, Type 1 55CD120b Monocytes, Granulocytes, TNF Receptor, Type 2 75Activated lymphocytesCD121a T cells, Fibroblasts, Endothelial cells IL-1 Receptor, Type 1 80CD121b B cells, Monocytes, Macrophages IL-1 Receptor, Type 2 68CD122 T cell subset, NK cells IL-2 Receptor Chain 75CD123 Progenitor cells, Granulocytes, Monocytes, Megakaryocytes, IL-3 Receptor Chain 70CD124 B cells, T cells, Progenitor cells IL-4/IL-13 Receptor 140CD125 Eosinophils, Basophils IL-5 Receptor Chain 60CD126 Plasma cells, Activated B cells IL-6 Receptor Chain 80CD127 Early B cells, T cells, Progenitor cells, Monocytes, IL-7 Receptor Chain 65-75CD129 Not assignedCD130 Plasma cells, Activated B cells gp130Receptor Subunit for IL-6,IL-11,LIF, OSM,LNTF,CT-1 130CD131 Myeloid cells Common Chain for IL-3, IL-5, GM-CSF Receptor 120CD132 Broad Common Chain for IL-2, IL-4, IL-7, IL-9, IL-15 Receptors 64CD133 Stem cell subset AC-133 120CD134 Activated T cell subset OX40 48-50CD135 Progenitor cell subset Flt3/FIk2 130-150CD136 Epithelial cells Macrophage Stimulating Protein Receptor 180CD137 T cell subset 4-1BB 30CD138 Plasma cells, Epithelial cells SYNDECAN-1 20CD139 Germinal center B cells 209,228CD140a (Undetectable on most normal cells) PDGF Receptor 180CD140b Endothelial cell subset, Stromal cells PDGF Receptor 180CD141 Endothelial cells Thrombomodulin 100CD142 Activated Monocytes and Endothelial cells Tissue Factor 45CD143 Endothelial cell subset Angiotensin Converting Enzyme 170CD144 Endothelial cells VE-CADHERIN 135CDw145 Endothelial cells, Some stromal cells 25,90,110CD146 Endothelial cells, Activated T cells MUC18/S-endo 118CD147 Endothelial cells, Monocytes, T cell subset, Platelets, Erythrocytes, Neurothelin/Basigin50-60CD148 Hematopoietic cells HPTP-ETA/DEP-1CD150 T cell subset, B cell subset, Thymocytes SLAM 70CD151 Platelets, Endothelial cells PETA-3 27CD152 Activated T cells CTLA-4 44CD153 Activated T cells CD30 Ligand 40CD154 Activated T cells, Mast cells, Basophils CD40 Ligand 33CD155 Monocytes, Macrophages, Thymocytes Poliovirus Receptor 80-90CD156a Monocytes, Macrophages, Granulocytes ADAM8 60CD156b Broad TACE/ADAM17 85CD156c Broad ADAM-10 98CD157 Monocytes, Neutrophils, Endothelial cells BST-1 42-45CD158 T cell subset, NK cell subset see note 2 in notes sectionCD158a NK cells, T cell subset p58.1, P50.1 50,58CD158b NK cells, T cell subset p58.2, p50-2 50,58CD159a NK cells NKG2a 43CD159c NK cells NKG2C 40CD160 T cell subset, NK cell subset By55 26CD161 NK cells, T cell subset NKR-P1 60CD162 T cells, Monocytes, Granulocytes, B cell subset PSGL-1 110CD162R NK cell subset PEN5 CHOCD163 Monocytes KiM4 130CD164 T cells, Monocytes, Granulocytes, B cell subset, Progenitor cells MGC-24 80CD165 Thymocytes, Thymic epithelial cells AD2/gp37 37CD166 Activated Lymphocytes, Endothelial cells, Fibroblasts ALCAM, CD6 Ligand 100CD167a Epithelial cells, Myoblasts Discoidin Domain Receptor, DDR1 120CD168 Thymocyte subset, T cell subset, Monocytes RHAMM 84-88CD169 Macrophage subset Sialoadhesin 185CD170 Macrophage subset, Neutrophils Siglec-5 140CD171 Monocytes, T cell subset, B cells L1 200CD172a Monocytes, T cell subset, Stem cells SIRP 110CD172b Monocytes, Dendritic cells SIRP 1 50CD172g T cells, Activated NK cells SIRP , SIRP 2 45-50CD173 Red cells, Stem cell subset, Platelets Blood group H type 2 CHOCD174 Stem cell subset, Epithelial cells Lewis Y CHOCD175 Stem cell subset TN CHOCD175s Erythroblasts Sialyl-Tn CHOCD176 Stem cell subset Thomson-Friedrenreich antigen CHOCD177 Neutrophil subset NB1 56-62CD178 Activated T cells Fas ligand 38-42CD179a Pro-B cells, Pre-B cells V pre beta 16CD179b Pro-B cells, Pre-B cells Lambda 5 22CD180 B cell subset, Monocytes, Dendritic cells Rp105/Bgp 95 95-105CD181 Neutrophils, T cell subset CXCR1 39CD182 Monocytes, Granulocytes, T cell subset CXCR2 40CD183 Activated T cells, Activated NK cells CXCR3 40CD184 T cell subset, B cells, Monocytes, Dendritic cells, Endothelial cells, CXCR4 45CD185 B cells, T cell subset CXCR5 45CD186 T cell subset CXCR6, BONZO 40CD191 T cells, Monocytes, Stem cell subset CCR1 39CD192 Monocytes, T cell subset, B cells, Basophils, Endothelial cells， CCR2 40CD193 Eosinophils, Basophils, T cell subset, Dendritic cell subset， CCR3 45CD194 T cells, Bascphils, Platelets, Monocytes (low) CCR4 41CD195 Monocytes, T cell subset CCR5 45CD196 T cell subset, B cells, Dendritic cell subset CCR6 45CD197 T cell subset CCR7 45CDw198 T cell subset, Monocytes CCR8 50CDw199 T cell subset CCR9 50CD200 Thymocytes, B cells, Endothelium, Activated T cells OX-2 45-50CD201 Endothelial cell subset Endothelial cell Protein C Receptor(EPCR) 50CD202b Endothelial cells, Stem cells Tie/Tek 150CD203c Basophils, Megakaryocytes NPP3 130-150CD204 Macrophages Macrophage Scavenger Receptor 220CD205 Dendritic cells, Thymic epithelium DEC-205 205CD206 Dendritic cell subset, Macrophages, Monocytes Macrophage Mannose Receptor 180CD207 Immature langerhans cells Langerin 40CD208 Interdigitating dendritic cells DC-LAMP 70-90CD209 Dendritic cell subset DC-SIGN 44CDw210 T cells, B cells, NK cells, Monocytes, Macrophages IL-10R 90-110CD212 Activated T cells, Activated NK cells IL-12R1 100CD213a1 B cells, Monocytes, Fibroblasts, Endothelial cells IL-13R1 65CD213a2 B cells, Monocytes IL-13R2 65CD217 Broad IL-17R 120CD218a Lymphocytes, Neutrophils, Dendritic cell subset IL-18R 70CD218b Lymphocytes, Neutrophils, Dendritic cell subset IL-18R 70CD220 Broad Insulin Receptor 140 + 70CD221 Broad IGF-1 Receptor 140 + 70CD222 Broad IGF-2 Receptor/ Mannose-6-phosphate Receptor 250CD223 Activated T cells, Activated NK cells LAG-3 70CD224 Leukocytes, Stem cells Gamma Glutamyl Transferase (GGT) 27, 68CD225 Broad Leu-13 17CD226 T cells, NK cells, Monocytes, Platelets DNAM-1 65CD227 Stem cell subset, Epithelial cells MUC-1 300CD228 Stem cells, Melanoma cells Melanotransferrin 80-95CD229 T cells, B cells Ly-9 95, 110CD230 Broad Prion Protein 35CD231 T cell leukemia, Neuroblastoma TALLA-1 30-45CD232 Broad VESPR (Plexin C1) 200CD233 Red cells Band 3 90CD234 Red cells Duffy 35-45CD235a Red cells Glycophorin A 36CD235b Red cells Glycophorin B 20CD236 Stem cell subset, Red cells Glycophorin C/D 32/23CD236R Stem cell subset, Red cells Glycorphorin C 32CD238 Stem cell subset, Red cells Kell 93CD239 Stem cell subset, Red cells B-CAM, Lutheran 78-85CD240CE Red cells Rhesus 30 CE 30-32CD240D Red cells Rhesus 30 D 30-32CD241 Red cells Rhesus 50 Glycoprotein 50CD242 Red cells ICAM-4 42CD243 Stem cells MDR-1 180CD244 NK cells, T cell subset 2B4 70CD245 T cell subset p220/240 220-240CD246 Anaplastic T cell leukemia Anaplastic Lymphoma Kinase 80CD247 T cells, NK cells TCR zeta chain 16CD248 Stromal Fibroblasts, Tumor endothelium Endosialin 175CD249 Endothelial cells, Epithelial cells Aminopeptidase A 160CD250 Reserved for TNFCD251 Reserved for lymphotoxinCD252 Dendritic cells, Endothelial cells, Activated B cells OX40 Ligand 34CD253 Activated T cells, Activated B cells, Activated monocytes TRAIL 33-34CD254 Activated T cells, Stromal cells, Osteoblasts TRANCE, RANKL 35CD255 Reserved for TWEAKCD256 Myeloid cells APRIL 16CD257 Myeloid cells BlyS, BAFF 45CD258 Activated T cells, Immature dendritic cells LIGHT 28CD259 Reserved for NGFCD260 Reserved for lymphotoxin beta receptorCD261 Leukocytes (very weak), Tumor cells TRAIL-R1, APO2 57CD262 Broad TRAIL-R2, DR5 60CD263 Broad (weak) TRAIL-R3, DcR1 65CD264 Broad TRAIL-R4, DcR2 35CD265 Broad, Osteoclasts, Dendritic cells RANK, TRANCE-R 97CD266 HUVEC TWEAK-R 14CD267 B cells (weak), Activated T cells TACI 32CD268 B cells, T cells (weak) BAFF-R 25CD269 B cells BCMA 27CD270 Reserved for LIGHTRCD271 Neurons, Stromal cells, Follicular dendritic cells NGFR 75CD272 Th1 cells BTLACD273 Dendritic cells, Activated T cells, Activated monocytes B7-DC, PD-L2 25CD274 Dendritic cells, Activated T cells, Activated monocytes B7-H1, PD-L1 40CD275 Dendritic cells, B cells (weak), T cells (weak), Activated monocytes， ICOSL 60CD276 Dendritic cell subset, Activated monocytes B7-H3 (long) 40-45CD277 T cells, B cells, NK cells, Monocytes, Dendritic cells, Stem cell， BT3.1, BTF5 56CD278 Activated T cells ICOS, AILIM 56CD279 Activated T cells, Activated B cells PD1 55CD280 Myeloid progenitors, Fibroblasts, Endothelial cell subset, Macrophage subset， Endo180, TEM22 180CD281 Monocytes, Neutrophils TLR1, TIL 90CD282 Monocytes, Neutrophils TLR2, TIL4 85CD283 Fibroblasts, Dendritic cells TLR3 100CD284 Monocytes (weak) TLR4 85CD285 Reserved for TLR5CD286 Monocytes, Dendritic cells, Endothelial cells TLR6 92CD287 Reserved for TLR7CD288 Peripheral blood leukocytes, Monocytes, Dendritic cells TLR8 120CD289 Dend