药理学镇痛药课件.ppt

镇痛药Analgesics Teacher DuCanInstructor jinlong Huang OpioidalkaloidsnarcoticanalgesicsSyntheticpainrelieversothersAntipyreticanti inflammatoryanalgesic analgesics Papaversomniferum 罂粟 Poppies 罂粟花 Poppyfruit 罂粟果 opium Morphine refiningfromtheopium Bitter white needle crystallizationpowder Opioidreceptor painpathwayslimbicsystemCNSlocuscoeruleusnuclearmidbraincoverformernuclearsolitarynucleusthedigestivecanalsmoothmuscle Pharmacologicaleffects 1 CentralNervousSystem 1 analgesiaandsedative 2 respiratorydepression 3 depressedcough 4 otheractions 2 PeripheralSystem 1 gastrointestinaleffects diastolicgastrointestinalsmoothmuscle inhibitthesecretionofdigestive inhibitCNS 2 cardiovascularsystem dilatebloodvessels increasesintracranialpressure Constipation 便秘 3 ImmuneSystem 1 immunosuppression Clinnicaluses 1 analgesia 1 acutesharppain 2 biliaryandkidneycolicetc combinedwithatropine2 acutepulmonaryedema 1 vasodilation 2 sedative 3 inhibitingrespiration3severediarrhea Adverseeffects monsideeffects 1 nausea vomiting constipation 2 respiratorydepression 3 hypotension 2 toleranceandphysicaldependence Contraindication 1 womenindeliveryandlactation 2 patientswithbronchialasthmaandpulmonaryheartdisease 3 patientswithcranialinjuryandhighcranialpressure 1 药理学 教材杨宝峰苏定冯主编人民卫生出版社2013年出版2 药理学 教材颜光美主编高等教育出版社2009年出版3 病理生理学 英文版教材王建枝陈国强主编科学出版社2007年出版 References ReviewQuestions 1 Whatisthemorphinepharmacologicaleffects 2 Whatisthe