[生物医药论文精品a]野西瓜挥发油抑制sgc-7901细胞增殖的研究

1STUDYONINHIBITIONOFTOTALOILINCAPPARISSPINOSAINPROLIFERATIONOFHUMANGASTRICCARCINOMACELLJIYUBIN1,2,3,WANGWEI1,YULEI1,2,3,CUIRONGTIAN1,MOKE1，ZOUXIANG1,2,31CENTEROFRESEARCHANDDEVELOPMENTONLIFESCIENCESANDENVIRONMENTALSCIENCES,HARBINUNIVERSITYOFCOMMERCE,HARBIN150076,CHINA2INSTITUTEOFMATERIAMEDICAANDPOSTDOCTORALPROGRAMMEOFHARBINUNIVERSITYOFCOMMERCE,HARBIN150076,CHINA3ENGINEERINGRESEACHCENTEROFNATURALANTICANCERDRUGS,MINISTRYOFEDUCATIONABSTRACTA1OBJECTIVETOSTUDYTHEANTINEOPLASTICEFFECTOFOILMETHODSMTTANDSRBWEREUSEDTOSTUDYANTINEOPLASTICACTIONOFOILINVITROTHEEFFECTOFOILONCELLAPOPTOSISANDDIFFERENTSTAGESOFCELLCYCLESINHUMANGASTRICCARCINOMASGC7901CELLSWASSTUDIEDBYFLOWCYTOMETRYRESULTSA1THEPROLIFERATIONOFSGC7901CELLSWASINHIBITEDAFTERTREATEDWITH10A250A2100A2150AND200G/MLTHETOTALOILINCAPPARISSPINOSAFOR72HANDTHEIC50IS1455G/ML,GI50IS12132G/MLA3LC50IS90096G/MLA3TGIIS24055G/MLAFTERSGC7901CELLSWERETREATEDBYTHETOTALOILINCAPPARISSPINOSAFOR24H,MORPHOLOGICALCHANGESOFAPOPTOSISWEREOBSERVEDTHEAPOPTOTICCELLSWEREDETECTEDAFTERTREATINGWITH75A2150AND300G/MLOFTHETOTALOILINCAPPARISSPINOSAFOR24HCELLCYCLEWASALSOANALYZED,WITHRESULTSSHOWINGTHATTOTALOILINCAPPARISSPINOSLEADSTOOBSTRUCTINGOFSSTAGECONCLUSIONOILHASSIGNIFICANTANTITUMOUREFFECTITSMECHANISMOFANTINEOPLASTICACTIONCOULDBEATTRIBUTEDTOITSACTIONOFINITIATINGTHEAPOPTOSISOFTUMORCELLSKEYWORDSCAPPARISSPINOSATOTALOILSAPOPTOSIS野西瓜挥发油抑制SGC7901细胞增殖的研究季宇彬1,2,3，于蕾1,2,3，王崴1，崔荣田1，莫科1,邹翔1,2,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,A182,A183A184A185A183A184A186A185A187A188,A183A184A189A190A191,A192A193A194A195A196A197A198A199A200A201A192A193A202A203A204A205A203A204TEL045184844242EMAILWANGWEI1982225SOHUCOM2A206A207A208A209A210A211A212A213A214A197A198A199A215A216A217A218A197A198A199A219A220A221A222A190A198A199A223A224A225A226A217A227A228A229A230A231A232A233A234A235A236A237A234A238A239A240A241A231A232A233A242CAPPARISSPINOSALA243A244A245A246A247A233A248A249A250A251A252A253A254A245A255A131A0A1A2A134A135A255A136A3A134A252A74A250A251A4A250A251A5A6A7A8A9A252A142A10A11A12A145A10A11A12A146A13A12A145A146A13A14A15A16A17A18A19A20A21A22A23A13A24A25A26A155A27A28A29A30A31A32A12A158A33A12A160A34A32A12A162A32A35A36A37A164A38A39A40A12A168A41A12A170A42A43A12A35A44A45A46A15A26A164A38A175A15A47A481A1381A178A37A39A40A166A175A15A17A28A29A37A180A49A50A51A52A14A175A11A53A54A26A55A56A57A30A58A59A60A61A62A63A64A65A66A28A67A68A69A70A36A28A71A721A37A195A57A58A23A73A75A76A77A22A71A72A78A79A198A80A37A81A70A200A62A23A73A75A39A82A37A81A83A84A85A86A87A88A89A90A91A28A22A92A77A37A62A61A58A93A94A22A82A95A96A63A37A140A212A97A98A99A100A101A212A97A102A103A104A105A35A106A61A62A107A22A23A73A75A76A77A37A108A109A103A104A70A105A35A106A61A62A107A57A110A111A112SGC7901A113A114A115A116A180A117A57A58A118A119A28A29A22A120A121A37A212A122A123A124A71A72A58A23A73A75A76A77A117A125A126A261实验材料11A127A128A129A130A132A133A137A139A141A143A144A147A148A149A150A151A152A153A154A156A157A15912A161A163A165A167A169A171A163A165A167A169A231A172A173A174A176A177A179A181A18260A183A184,A235A185A186A187100GA188A1892LA238A190A191A192A193A194,A244A196A197A199A201A202A203A204A205A206A207A208A209A2082,A210A211A203A204A205A206A207A213A214A215,A216A217A218A219A205A220A221A222A223A224A225A254A226A201A227A221A205A228,A211A229A205A230A232A215A199A2333A234A236A237A205A228A239A240A201A211A241A242A243A204A245A246A247A229A205A230,A248A249A250A251A252A253A255A7A19A0A1A205A22A112A23A223A203A204A205A225A228A248A203A204A205A24A2A3A26A36A3A27A173A28A2111A22513A20A4A5A6A8A4A5A6A8A216A9A10A43A11A29SGC7901,A222A12A13A14A15A16A17A18A21A25A30A31A32A33A3414A35A37A38A39A37A38RPMI1640A152A40A95A41A42A44A45A46A47A48A98A159A49GIBCOA50A51A99A52A53A54A55A56A44A57A249A95A58A59DMSOA44A60A189A61A62PIA52MTTA98SIGMAA50A51A99A52A63A64A65A98A66A89A67A68A111A69A70A71A114A72A50A51A99A52HOECHST3325820A73A74A75A52A76A67A77A78A80A79A81A82A114A72A50A51,A83A84A85A86A115BSULFORHODAMINEB,SRBSIGMAA177A8715A88A90A91A92A93A94A90A91A92A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