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1、 why did a promising heart drug fail?doomed drug highlights complications of meddling with cholesterol.5. researchers are now trying to work out why and how the drug backfired, something thatwill not become clear until the clinical details are released by pfizer. one hint lies in evidencefrom earlie
2、r trials that it slightly raises blood pressure in some patients. it was thought that thismild problem would be offset by the heart benefits of the drug. but it is possible that it actuallyproved fatal in some patients who already suffered high blood pressure. if blood pressure is theexplanation, it
3、 would actually be good news for drug developers because it suggests that theproblems are specific to this compound. other prototype drugs that are being developed to blockcetp work in a slightly different way and might not suffer the same downfall.6. but it is also possible that the whole idea of b
4、locking cetp is flawed, says motikashyap, who directs atherosclerosis research at the va medical center in long beach,california. when hdls excrete cholesterol in the liver , they actually rely on ldls for part ofthis process. so inhibiting cetp, which prevents the transfer of cholesterol from hdl t
5、o ldl,might actually cause an abnormal and irreversible accumulation of cholesterol in the body. youreblocking a physiologic mechanism to eliminate cholesterol and effectively constipating thepathway, says kashyap.going up精品文档 精品文档 i. how does torcetrapib work?ii. contradictory result prior to the c
6、urrent trialiii. one failure may possibly bring about future successiv. the failure doesnt lead to total loss of confidencev. it is the right route to followmatch torcetrapib,hdls,statin and cetp with their functions (questions 8 -13)write the correct letter a, b, c or d in boxes 8-13 on your answer
7、 sheet.nb you may use any letter more than once.7.it has been administered to over 10,000 subjects in a clinical trial.8.it could help rid human body of cholesterol.9.researchers are yet to find more about it.10. it was used to reduce the level of cholesterol.11. according to kashyap, it might lead to unw
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