急性缺血性脑卒中的三维血流成像英文

1、3D Blood Volume Imaging Acute Ischemic StrokeComprehensive Imaging in 15 MinutesPerfusion CT Images from PCT: MIPCBFCBVTTP BUT: limited coverageWhole brain perfusionis ideal!Calculating 3D-PBV ImagesCTAlow pass filteringNECTRegistrationuses information3D PBVSkullBonesCSFBonesVesselsPre-Studiesof 3D-

2、PBVMaterials and Methods Twenty-five patients (7 women, 18 men; mean age 59 years; range 42-77 years) suffered from acute ischemic stroke of the anterior circulation were studied within 6h after onset of symptomsNECT, CTA and CTP were performed within an average time of 2.8 hours (range 1-6 hours) a

3、fter onset of symptomsIntravenous or intra-arterial thrombolytic therapy was performed in 11 of 25 patients Follow-up CT and MRI examinations were done at 2 to 7 days for the depiction of definite infarctionCT Scan ProtocolResultsNECT: signs of ischemia were demonstrated in 13 of 25 acute stroke pat

4、ientsCTP: CBF, CBV, and TTP demonstrated perfusion deficits in 21 patients CBF, CBV, and TTP demonstrated suspected perfusion deficits in 2 patients Only TTP demonstrated perfusion deficits in 2 of 25 patients3D-PBV: demonstrated perfusion deficits in all of the 25 acute stroke patients 3D-PBV has a

5、 higher detection rate for infarct lesion than NECT and CTP, and can depict the whole infarction lesionResultsCTP: lesion volume significantly correlated with the follow-up CT (R=0.776/P0.001 for CBF; R=0.723/ P0.001 for CBV; R=0.629/P=0.001 for TTP)PBV: lesion volume significantly correlated with t

6、he follow-up CT (R=0.837, P0.001)Volume cm3R=0.776P0.001R=0.723P0.001R=0.629P=0.001R=0.837P0.001CBF-follow-up CTCBV-follow-up CTTTP-follow-up CTPBV-follow-up CTResultsThrombolysis GroupThrombolysis GroupR=0.755P=0.007PBV-follow-up CTCBF-follow-up CTCBV-follow-up CTTTP-follow-up CTR=0.851P0.001R=0.81

7、1P0.001R=0.829P0.001R=0.807P0.001Conclusions3D PBV can improve detection rate of ischemia by avoiding lesion omitting and assess the full extent of ischemia which correlates well with follow-up plain CT3D PBV requires no additional scan or contrast injection and can be performed in a short period of

8、 time. The integration of 3D-PBV with multimodal CT (NECT, CTP and CTA) can add the diagnostic value in acute ischemic strokeTEXTNECTCTA CTP 3D-PBVAcute Ischemic Stroke New Multimodal CT Protocol Jie Lu M.D.,Ph.D.Miao Zhang M.D.Xiangying Du M.D.,Ph.D.Yan Gao M.D.Yunyun Duan M.D.Yanxiang Cao M.D.Xin

9、Sui M.D.AcknowledgmentsSiemens Ltd., ChinaJiu-hong Chen Ph,D.Reto D. MergesThrombolysis GroupR=0.755P=0.007PBV-follow-up CTCBF-follow-up CTCBV-follow-up CTTTP-follow-up CTR=0.851P0.001R=0.811P0.001R=0.829P0.001R=0.807P0.001TEXTNECTCTA CTP 3D-PBVAcute Ischemic Stroke New Multimodal CT Protocol Jie Lu M.D.,Ph.D.Miao Zhang M.D.Xian