国立中兴大学农资学院(中心)食品暨应用生物科技学系所特聘教授

1、 國立中興大學農資學院（中心）食品暨應用生物科技學系所特聘教授推薦表 姓 名胡淼琳性 別男出 生 年 月 日 1949.5.14現 職教 授身分證號碼略特聘教授聘期 自民國 98 年 8 月 1 日起至 100 年 7 月 31 日止適 用 條 款符合國立中興大學特聘教授設置辦法第三條第一項第 三 款規定。（第一款者得免經學院特聘教授審查小組審查） 證 明 文 件曾獲國科會傑出研究獎證明文件。獲本校教學特優教師獎證明文件。獲國科會年度專題研究計畫研究主持費證明文件國內外著名學術獎或在國際學術上有傑出貢獻證明文件。學經歷、著作目錄、重要論著、具體學術成就證明及其他相關證明文件。建議獎助金每月新台

2、幣 貳 萬元（第一款）每月新台幣 壹 萬元（第二、三款）每月新台幣 元（第四款）推 薦 理 由胡淼琳特聘教授致力於基礎營養生化與自由基氧化破壞之相關研究成果傑出,迄今已發表約90篇SCI論文,近五年內SCI期刊論文則有29篇,專利1件,研究表現指數(RPI)達100。另外,胡教授近三年研究計劃計八件,並於民國94年獲國科會優良獎,為期2年。期間亦出版一本有關科學英文論文寫作之教科書,教學與研究均表現非凡,故推薦為本校特聘教授。本系所現已獲聘特聘教授人數： 0 人本學院現已獲聘特聘教授人數：4 人 聘用單位主管簽章：院長簽章：學院特聘教授審查小組意見推薦，推薦順序： 不推薦 召集人簽章：會辦單位

3、人事室本校特聘教授評審委員會民國 年 月 日學年度 第次會議決議：召集人簽章：校 長 批 示研發處會計室 系所聯絡人： 分機：本推薦表共3頁，第2頁學歷學校名稱系所學位修業起訖年月美國德州理工大學食品營養系博士1979 年 06 月至1983 年 05 月國立師範大學生物所碩士1973 年 09 月至1975 年 07 月國立中興大學植物系理學士1967 年 09 月至1971 年 06 月年 月至年 月年 月至年 月經歷服務學校(機關)名稱職稱專 任或兼 任任職起訖年月擔任課程名稱或職務國立中興大學特聘教授專 任2007年8月至2009年8月國立中興大學教授專 任1997年8月至 迄今國立中

4、興大學副教授專 任1992年8月至1997年7月美國加大戴維斯分校研究員1992 年1月至1992年8月美國加大戴維斯分校博士後研究1985年11月至1992年1月食品工業發展研究所副研究員1975年9月至1977年7月重要學術成就或論著請詳見附件資料 附註：重要學術成就或論著請至少鈎選一項，並以A4格式併推薦表送件。Miao-Lin Hu, Ph.D., Distinguished ProfessorNational Chung Hsing UniversityTaichung Taiwan(一) SCI及國外期刊著作 (至2009年共發表90篇，畫底線者為corresponding aut

5、hors)1. Hu, M.-L. and Spallholz, J. E. (1983). In vitro hemolysis of rat erythrocytes by selenium compounds. Biochem. Pharmacol. 32: 957-961.2. Hu, M.-L., Chung, C. and Spallholz, J. E. (1984). Hematological data of selenium- deficient and selenium-supplemented rats. J. Inorg. Biochem. 22: 165-173.3

6、. Hu, M.-L. and Spallholz, J. E. (1985). Dietary selenium and aniline-induced methemoglobinemia in rats. Toxicol. Lett. 25: 205-210. 4. Hu, M.-L. and Tappel, A. L. (1987). Selenium as a sulfhydryl redox catalyst and survey of potential selenium- dependent enzymes. J. Inorg. Biochem. 30: 239-248.5. D

7、illard, C. J., Hu, M.-L. and Tappel, A. L. (1987). Effect of aurothioglucose on glutathione and glutathione- metabolizing and related enzymes in rat liver and kidney. Chem- Biol. Interact. 64: 103-114.6. Hu, M.-L., Viljoen, A. J. and Tappel, A. L. (1988). Interactions of gold with cytosolic selenium

8、-containing proteins in rat kidney and liver. J. Inorg. Biochem. 32: 281-290. 7. Hu, M.-L., Dillard, C. J. and Tappel, A. L. (1988). Aurothioglucose effect on sulfhydryls and glutathione- metabolizing enzymes: in vivo inhibition of selenium-dependent glutathione peroxidase. Res. Commu. Chem. Pathol.

9、 Pharmacol. 59: 147-160.8. Hu, M.-L., Dillard, C. J. and Tappel, A. L. (1988). Effect of chronic aurothioglucose treatment of rats kidney catalase and cytochromes. J Inorg. Biochem. 33: 175-181.9. Hu, M.-L., Dillard, C. J. and Tappel, A. L. (1988). In vivo effects of aurothioglucose and sodium thiog

10、lucose on rat tissue sulfhydryl levels and plasma sulfhydryl reactivity. Agents and Actions 25: 132-138.10. Frankel, E. N., Hu, M.-L. and Tappel, A. L. (1989). Rapid headspace gas chromatography of hexanal as a measure of lipid peroxidation in biological samples. Lipids 24: 976-981.11. Hu, M.-L., Fr

11、ankel, E. N., Leibovitz, B. E. and Tappel, A. L. (1989). Effect of dietary lipids and vitamin E on in vitro lipid peroxidation in rat liver and kidney homogenates. J. Nutr. 119: 1574-1582. 12. Leibovitz, B., Hu, M.-L. and Tappel, A. L. (1990). Dietary supplements of vitamin E, beta-carotene, coenzym

12、e Q10 and selenium protect tissue against lipid peroxidation in rat tissue slices. J. Nutr. 120: 97-104. 13. German J. B. and Hu, M.-L. (1990). Oxidant stress inhibits the endogenous production of lipoxygenase metabolites in rat lungs and fish gills. Free Radical Biol. Med. 8: 441-448.14. Leibovitz,

13、 B. E., Hu, M.-L. and Tappel, A. L. (1990). Lipid peroxidation in rat tissue slices: Effects of dietary vitamin E, corn oil-lard and menhaden oil. Lipids 25: 125-129.15. Hu, M.-L., Frankel, E. N. and Tappel, A. L. (1990). Effect of dietary Menhaden oil and vitamin E on in vivo lipid peroxidation ind

14、uced by iron. Lipids 25: 194-198. 16. Dillard, C. J., Hu, M.-L. and Tappel, A. L. (1991). Vitamin E, diethylmaleate and bromotrichloromethane interactions in oxidative damage in vivo. Free Radical Biol. Med. 10: 51-60.17. Reznick, A. Z., Cross, C. E., Hu, M.-L., Suzuki, Y. J., Khwaja, S., Safadi, A.

15、, Motchnik, P., Packer, A. L. and Halliwell, B. (1992). Modification of plasma proteins by cigarette smoke as measured by protein carbonyl foramtion. Biochem. J. 286: 607-611.18. Hu, M.-L. and Tappel, A. L. (1992). Glutathione and antioxidants protect microsomes against lipid peroxidation and enzyme

16、 inactivation. Lipids 27: 42-45.19. Halliwell, B., Hu, M.-L., Louie, S., Duvall, T. R., Tarkington, B. K., Motchnik, P. and Cross, C. E. (1992). Interaction of nitrogen dioxide with human plasma antioxidant depletion and oxidative damage. FEBS Lett. 313: 62-66.20. Hu, M.-L. and Tappel, A. L. (1992).

17、 Potentiation of oxidative damage to proteins by ultraviolet A and protection by antioxidants. Photochem. Photobiol. 56: 357-63.21. Sano, M., Hu, M.-L. and Tappel, A. L. (1992). Potentiation of non-halocarbon oxidants on halocarbon-induced oxidative damage to rat red blood cells. J. Agric. Food Chem

18、. 40: 2192-2197.22. O'Neill, C. A., van der Vliet, A., Hu, M.-L., Kaur, H., Cross, C. E., Louie, S. and Halliwell, B. (1993). Oxidation of biological molecules by ozone: the effect of pH. J.Lab. Clin. Med. 122: 497-505.23. Hu, M.-L., Louie, S., Cross, C. E. Motchnik, P. and Halliwell, B. (1993).

19、 Antioxidant protection against hypochlorous acid in human plasma. J. Lab. Clin. Med. 121: 257-262.24. Cross, C. E. O'Neill, C. A. Reznick, A. Z., Hu, M.-L., Marcocci, L. Packer, L. and Frei, B. (1993). Cigarette smoke oxidation of human plasma constituents. in: Tobacco Smoking and Nutrition. An

20、nals New York Acad. Sci. 686: 72-90.25. van der Vliet, A., Hu, M.-L., O'Neill, C. A., Cross, C. E. and Halliwell, B. (1994). Interactions of human blood plasma with hydrogen peroxide and hypochlorous acid . J. Lab. Clin. Med. 124: 701-707. 26. Sano, M., Kawabata, H., Tomita, I., Yoshioka, H. and

21、 Hu, M.-L. (1994). Potentiation of oxidative damage to rat red blood cells by the concurrent presence of t-butyl hydroperoxide and bromotrichloromethane. J. Toxicol. Env. Health. 43: 339-350.27. Hu, M.-L. (1994). Measurement of plasma protein thiol groups and glutathione in plasma. Methods Enzymol.

22、233: 380-385.28. Hu, M.-L. and Chen, Y. K. and Lin, Y. F. (1995). Antioxidant and prooxidant activities of B vitamins and vitamin- like compounds. Chemico-Biol. Interact. 97: 63-73.29. Hu, M.-L., Chen, Y. K., Chen, L. J. and Sano, M. (1995). Para-aminobenzoic acid scavenges reactive oxygen species a

23、nd protects DNA against UV and free radical damage. J. Nutr. Biochem. 6: 504-508.30. Chen, L-C. and Hu, M.-L. (1995). Comparison of methods for determination of para-aminobenzoic acid (PABA). J. Food Drug Anal. 4: 75-87.31. Chang, D. Y. and Hu, M.-L. (1996). Concentrations and lipid peroxidation in

24、tissues and toxicity of para-aminobenzoic acid fed to rats in drinking water. J. Nutr. Biochem. 7: 408-413.32. Shih, M.-K. and Hu, M.-L. (1996). UVA-potentiated damage to calf thymus DNA by Fenton reaction system and protection by para-aminobenzoic acid. Photochem. Photobiol. 63: 286-291.33. Hu, M.-

25、L. and Shih, M.-K. (1997). Ascorbic acid inhibits lipid peroxidation but enhances DNA damage in rat liver nuclei incubated with iron ions. Free Radical Res. 26: 585-592.34. Hu, M.-L., Ng, H. P. and Shih, M.-K. (1997). Hemolytic effects of dehydroepiandrosterone in vitro. Life Sci. 61: 2137- 2142.35.

26、 Chang, C. Y., Lai, Y. C., Cheng, T. J. and Hu, M.-L. (1997). Plasma status of antioxidant vitamins and oxidative products in ischemic-stroke patients during early post-stroke stage. J. Appl. Nutr. 49: 77-83. (Non-SCI).36. Chang, C. Lai, Y. C., Cheng, T. J., Lau, M. T. and Hu, M.-L. (1998). Plasma l

27、evels of antioxidant vitamins, selenium, total sulfhydryl groups and oxidative products in ischemic-stroke patients as compared to matched controls in Taiwan. Free Radical Res. 28: 15-24.37. Hu, M.-L. and Tsai, H.-H. (1998). Reaction of cyclohexylamine with hypochlorite and enhancement of oxidation

28、of plasma sulfhudryl groups by hypochlorite. Food Chem. Toxicol. 36: 755-759. 38. Hu, M.-L. and Ng, H. P. (1998). Dietary selenium and vitamin E affect adrenal and brain dehydroepiandrosterone levels in young rats. J. Nutr. Biochem. 9: 339-343. 39. Shih, M.-K. and Hu, M.-L. (1999). UVA-induced oxida

29、tive damage to rat liver nuclei: reduction of iron ions and the relationship between lipid peroxidation and DNA damage. Mutation Res. 438: 125-132.40. Chiou, J.-F. and Hu, M.-L. (1999). Elevated lipid peroxidation and disturbed antioxidant activities in plasma and erythrocytes of patients with uteri

30、ne cervicitis and myoma. Clin. Biochem. 32: 189-192.41. Shih, M-K. and Hu, M-L. (1999). Relative roles of metal ions and singlet oxygen in UVA-induced liposomal lipid peroxidation. J. Inorg. Biochem. 77: 225-230. 42. Hu, M-L., Chang, C-Y., Lai, Y-C., Cheng, T-J. and Lau, M-T. (1998). Plasma levels o

31、f vitamins, antioxidants and oxidative products in ischemic-stroke patients as compared to matched controls in Taiwan. Atherosclerosis. 136: S61-S63.43. Ng, H.P., Wang, Y.F., Lee, C.Y. and Hu, M.-L. (1999). Toxicological and antioxidant effects of short-term dehydroepiandrosterone injection in young

32、 rats fed diets deficient or adequate in vitamin E. Food Chem. Toxicol. 37: 503-508.44. Wang, Y.F. and Hu, M.-L. (2000). Use of rat liver slices for study of oxidative DNA damage in comparison with rat liver nuclei and HepG2 cells. Food Chem. Toxicol. 38: 451-458.45. Yeh, S.-L. and Hu, M-L. (2000).

33、Antioxidant and pro-oxidant effects of lycopene in comparison with a-carotene on oxidant-induced damage in Hs68 cells. J. Nutr. Biochem. 11: 548-554.46. Hong, Y-L., Yeh, S-L., Chang, J-Y. and Hu, M-L. (2000). Total plasma malondialdehyde levels in 16 Taiwanese college students determined by various

34、TBA methods and an improved HPLC-based method. Clin. Biochem. 33: 619-625.47. Yang, N-C., Jeng, K-C. G., Ho, W.-M., Chou, S-J. and Hu, M-L. (2000). DHEA inhibits cell growth and induces apoptosis in BV-2 cells and the effects are inversely associated with glucose concentration in the medium. J. Ster

35、oid Biochem. & Mol. Biol. 75: 159-166.48. Yeh, S. L. and Hu, M.-L. (2001). Induction of oxidative DNA damage in Hs68 cells by oxidized b-carotene and lycopene. Free Radic. Res. 35:203-213.49. Yeh, S.-L. and Hu, M-L. (2001). Antioxidant and pro-oxidant effects of -carotene and lycopene on oxidant

36、-induced damage in Hs68 cells. In Micornutrients and health: molecular biological mechanisms (Nesaretnam, K. and Packer, L., eds.), American Oil Chemists Society, Champaign, Chapter 8, pp. 86-99.50. Hu, M.-L., Chuang, C-H., Sio, H-M. and Yeh, S.-L. (2002). Simple cryoprotection and cell dissociation

37、 techniques for application of the comet assay to fresh and frozen rat tissues. Free Radic. Res. 36: 203-209.51. Yang, N-C., Jeng, K-C. G., Ho, W.-M., Chou, S-J. and Hu, M-L. (2002). ATP Depletion is an important factor in DHEA-induced growth inhibition and apoptosis of BV-2 cells. Life Sci. 70:1979

38、-1988.52. Yang, N-C., Ho, W.-M., Chen, Y-H. and Hu, M-L. (2002). A convenient one-step extraction of cellular ATP for subsequent assay of bioluminescence using the luciferin-luciferase. Anal Biochem. 306: 323-327.53. Liu, S.-H., KO, W-C. and Hu, M-L. (2002). The hypolipidemic effect of proteoglycans

39、 from the sea cucumber Metriatyla scabra in rats fed a cholesterol-supplemented diet. J. Agric. Food Chem. 50: 3602-3606.54. Lee, S.C., Tsai, C.-C., Chen, J.-C., Lin, J.-G., Lin, C.-C., Hu, M.-L. and Lu, S. (2002). Effects of Chinese yam on hepato-nephrotoxicity of acetaminophen in rats. Acta Pharma

40、col. Sin. 23: 503-508.55. Lee, S.C., Tsai, C.-C., Chen, J.-C., Lin, C.-C., Hu, M.-L. and Lu, S. (2002). The evaluation of reno-hepatoprotective effects of “Huai Shan Yao” (Rhizoma Dioscoreae). Am. J. Chin. Med.30: 609-616.56. Yeh, S-L. and Hu, M.-L. (2003). Oxidized -carotene induces the formation o

41、f8-OH-deoxyguanosine in calf thymus DNA by the formation of reactive oxygen species. Food Chem. 81: 439-445.57. Yeh, S-L. and Hu, M.-L. (2003). Oxidized -carotene inhibits gap junction intercellular communication in the human lung adenocarcinoma cell line A549.Food Chem. Toxicol. 41: 1677-1684.58. D

42、ai, Y-Y., Chuang, C-H., Tsai, C-C., Sio, H-., Huang, S-C., Chen, J-C. and Hu, M.-L. (2003). Protection of Anthrodia camphorata against acute hepatotoxicity of alcohol in rats. J. Food Drug Anal. 11: 177-185.59. Yang, T.-H., Yang, N.-C. and Hu, M.-L. (2003). S-adenosylhomocysteine enhances hydrogen p

43、eroxide-induced DNA damage by inhibition of DNA repair. Nutr. Cancer. 47: 70-75.60. Wang, Z-J., Lin, S-M. and M.-L. Hu (2004). Contents of hypericin and pseudohypericin in five commercial products of St Johns wort. J. Sci. Food Agric. 84: 395-397. 61. Yang T-H., Chang C-Y. and Hu M-L. (2004). Variou

44、s forms of homocysteine and oxidative status in the plasma of ischemic-stroke patients as compared to healthy controls. Clin. Biochem. 37: 494-499. 62. Chuang CH, and Hu ML. (2004). Use of whole blood directly for single-cell gel electrophoresis (comet) assay both in vivo and in vitro. Mutat. Res. 5

45、64: 75-82. 63. Yang, N.-C. and Hu, M.-L. (2004). A fluorimetric method using fluorescein di-D-galactopyranoside for quantifying the senescence associated-galactosidase activity in human foreskin fibroblast Hs68 cells. Anal. Biochem.325: 337-343.64. Hu M-L. and Wang R-J. (2004). Antioxidant role of m

46、ulberry leaves in streptozotocin-diabetic rats. Clin Chim Acta. 348: 215 (Letter to the Editor). 65. Yeh, S-L., Huang, C-H., and Hu, M-L. (2005). Lycopene enhances UVA-induced DNA damage and expression of hemeoxygenase-1 in cultured mouse embryo fibroblasts. Eur. J. Nutr. 44:365-370.66. Yang, N-C. a

47、nd Hu, M-L. (2005). The limitations and validities of senescence associated-b-galactosidase activity as an aging marker for human foreskin fibroblast Hs68 cells. Exp. Gerontol. 40: 813-819.67. Chuanng, C-H. and Hu, M-L. (2005). Dietary deficiencies of Vitamin E and Selenium Increase DNA damage in Fr

48、ozen Tissues and Cultured Lymphocytes. Intl. J. Vitamin Nutr. Res. 75: 251-256.68. Huang, C-H., Shih, M-K., Chuang, C-H. and Hu, M-L. (2005). Lycopene Inhibits Cell Migration and Invasion possibly through down-regulation of Nm23-H1 in A Highly Invasive Hepatocarcinogma, SK-Hep-1 Cells. J. Nutr. 135:

49、 2119-2123.69. Yeh, S-L., Wang, W-Y., Huang, C-H. and Hu, M-L. (2005). Pro-oxidant effect of -carotene and the interaction with flavonoids on UVA-induced DNA strand breaks in mouse fibroblasts, C3H10T1/2 cells. J. Nutr. Biochem. 16: 729-735.70. Chang, C-Y., Chen, J-Y., Ke, D. and Hu, M-L. (2005). Pl

50、asma Levels of Lipophilic Antioxidant Vitamins in Acute Ischemic Stroke Patients: Correlation to Inflammation Markers and Neurological Deficits. Nutrition. 21: 987-993.71. Chuang, C-H. and Hu, M-L. (2006). Synergistic DNA Damage and Lipid Peroxidation in cultured human white blood cells exposed to 4

51、-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone and ultraviolet A. Envirn. Mol. Mutagenesis. 47: 73-81.72. Yeh, S-L., Wang, W-Y., Huang, C-H. and Hu, M-L. (2006). Flavonoids suppress the enhancing effect of -carotene on DNA damage induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A54

52、9 cells. Chem-Biol. Interact. 160: 175-182.73. Yang, T-H. and Hu, M-L. (2006). Intracellular levels of S-adenosylhomocysteine but not homocysteine are highly correlated to the expression of nm23-H1 and the level of 5-methyldeoxycytidine in human hepatoma cells with different invasion activities. Nut

53、r. Cancer 55: 22423174. Chen, J-Y., Chu, C-C., So, E. C., Hsing, C-H., Hu, M-L. (2006). Relief of post-herpetic neuralgia with vitamin C administration. Anesthesia & Analgesia 103:121 (Letter to the Editor).75. Chen, H-L., Hsu, C-Y., Hung, D-Z., Chia, T-P., Lee, C-C. and Hu, M-L. (2006) Lipid pe

54、roxidation and antioxidant status in workers exposed to PCDD/Fs of metal recovery plants. Sci. Total Environ. 372:12-19.76. Huang, C-H., Shih, M-K., Chuang, C-H. and Hu, M-L. (2006). Tissue accumulation of lycopene in different species of rodent. Intl. J. Vitamin Nutr. Res. 76: 377-384.77. Lin, P-Y.

55、, Yang, T-H., Lin, H-G. and Hu, M-L. (2007). Synergistic effects of S-adenosylhomocysteine and homocysteine on DNA damage in a murine microglial cell line. Clin. Chem. Acta 379: 139144.78. Lin, C-Y., Huang, C-S. and Hu, M-L. (2007). The use of fetal bovine serum as delivery vehicle to improve the up

56、take and stability of lycopene in cell culture studies. Br. J. Nutr. 98: 226-232. 79. Huang, C-H., Fan, Y-E., Lin, Z-Y. and Hu, M-L. (2007). Lycopene inhibits matrix metalloproteinase-9 expression and down regulates the binding activity of nuclear factor-kappa B and stimulatory protein-1. J. Nutr. B

57、iochem. 18: 449-456.80. Song, TY., Lin, H-C., Yang, N-C. and Hu, M-L. (2008). Antiproliferative and antimetastatic effects of the ethanolic extract of Phellinus igniarius (Linnearus:Fries) Quelet. J. Ethnopharmacol. 115:505681. Huang, C-S., Liao, J-W. and Hu, M-L. (2008). Lycopene inhibits experimental metastasis of human hepatoma SK-Hep-1 cells in athymic nude mice. J. Nutr. 138:538-543.82. Chuang, C-H. and Hu, M-L. (2008). L-Carnosine inhibits metastasis of SK-Hep-1 cells by inhibit