干细胞与黄斑营养不良

1、李乐医学院2014311842Human Embryonic Stem Cell-Derived Retinal Pigment Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium(RPE) in Patients with Macular DegenerationEpithelium(RPE) in Patients with Macular DegenerationDry Age-Related Macular Dry Age-Related Macular Degeneration(AMD)Degeneration(A

2、MD)干性年龄相关性干性年龄相关性黄斑变性黄斑变性StargardtsStargardts disease(STGD)disease(STGD)少年型黄斑营养不良少年型黄斑营养不良 Dry age-related macular degeneration is the leading cause of blindness in the developed world. Stargardts macular dystrophy is the most common paediatric macular degeneration.http:/ of eyesStructure of eyeshtt

3、p:/www.riken-ibri.jp/AMD/english/summary.htmlhttp:/www.riken-ibri.jp/AMD/english/summary.htmlhttp:/ Human Embryonic Embryonic Stem CellsStem Cells( (hESCshESCs) )Transplantation of hESC-derived RPE cell sheethttp:/www.riken-ibri.jp/AMD/english/summary.htmlReferencesReferences Schwartz, S. D., Hubsch

4、man, J.-P., Heilwell, G., Franco-Cardenas, V., Pan, C. K., Ostrick, R. M., Lanza, R. (2012). Embryonic stem cell trials for macular degeneration: a preliminary report. Lancet, 379(9817), 71320. doi:10.1016/S0140-6736(12)60028-2 Schwartz, S. D., Regillo, C. D., Lam, B. L., Eliott, D., Rosenfeld, P. J., Gregori, N. Z., Lanza, R. (2014). Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardts macular dystrophy: follow-up of two open-label phas