Nefiracetam-DM9384-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemENefiracetamCat. No.: HY-B0340CAS No.: 77191-36-7Synonyms: DM9384; DZL-221分式: CHNO分量: 246.3作靶点: GABA Receptor作通路: Membrane Transporter/Ion Channel; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C

2、1 month溶解性数据体外实验 DMSO : 100 mg/mL (406.01 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 4.0601 mL 20.3004 mL 40.6009 mL5 mM 0.8120 mL 4.0601 mL 8.1202 mL10 mM 0.4060 mL 2.0300 mL 4.0601 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适

3、当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (10.15 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (10.15 mM); Clear

4、solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (10.15 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Nefiracetam作于Ro 5-4864引起的抽搐，是GABAergic，胆碱及单胺类的神经系统增强剂。REFERENCES1. Nishizaki, T., et al., Nefiracetam modulates acetylcholine receptor cu

5、rrents via two different signal transduction pathways. MolPharmacol, 1998. 53(1): p. 1-5.2. Shiotani, T., et al., Anticonvulsant actions of nefiracetam on epileptic EL mice and their relation to peripheral-type benzodiazepinereceptors. Brain Res, 2000. 859(2): p. 255-61.3. Sakurai, T., et al., Effects of N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide (DM-9384) on learning and memory in rats. Jpn JPharmacol, 1989. 50(1): p. 47-53.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-37