TR-14035 - Integrin Antagonist - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETR-14035Cat. No.: HY-15770CAS No.: 232271-19-1分式: CHClNO分量: 474.33作靶点: Integrin作通路: Cytoskeleton储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 41 mg/mL (86.44 mM)* means soluble, but satur

2、ation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.1082 mL 10.5412 mL 21.0824 mL5 mM 0.4216 mL 2.1082 mL 4.2165 mL10 mM 0.2108 mL 1.0541 mL 2.1082 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 TR-14035是47/41 integrin拮抗剂，IC50为7 nM和87 nM。户使本产品发表的科研献 Obesity. 2015

3、 Apr;23(4):779-85.1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE PLoS One. 2016 Feb 3;11(2):e0148333.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Sircar I, et al. Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: discovery of TR-14035, a dualalpha(4)beta(7)/al

4、pha(4)beta(1) integrin antagonist. Bioorg Med Chem. 2002 Jun;10(6):2051-66.2. Egger LA, et al. Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow. JPharmacol Exp Ther. 2002 Jul;302(1):153-62.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 02