5.初级版课件3english vesion英文版-abridged introduction

1、 e to attend Prof. Rongwu Yangs lecture! e to enter the mysterious biochemical world!Some Rules or SuggestionsTurn off your cell phone or switch it into silent mode when in classDont take notes too seriously, Just focus on listening and understanding Either you come here on time or you wontYou can s

2、leep in class, but dont snore!Dont ask me for mercy when you get poor grades in this coursePlease. turn all cell phones off turn pagers offViolations and PenaltiesZero-tolerance PolicyEach time: Loss of 5 points or buy everyone in the classroom one cup of coffee or one ice creamDuring Exam:Loss of 1

3、0 points When in classGrading PolicyClass Participation: 5%Term paper or Translation: 5%Quiz: 10%Mid-term Exam: 30%Final Exam: 50% Extra credit (10 points): presentationBiochemistry Biochemistry.mp3Biochemistry BiochemistryI wish that I were wiserI feel Im in way over my headI need a new advisorMy c

4、ourses really shouldnt beSuch metabolic miseryBiochemistry BiochemistryI wish that I were wiserBiochemistry BiochemistryReactions make me shiverTheyre in my heart and in my lungsTheyre even in my liverBiochemistry (cont.)I promise I would not complainIf I could store them in my brainBiochemistry Bio

5、chemistryI wish that I were wiserBiochemistry BiochemistryIm truly in a panicThe mechanisms murder meI should have learned organicFor all I have to memorizeI ought to win the Nobel Prize.Biochemistry BiochemistryI wish that I were wiserGeneral tips on how to succeedJust do as a proverb says:I hear,

6、and I forget,I see, and I remember,I do, and I understand. More specific tips for successRead the book as much as you can.Print out the slides (1-2/page) and bring them to lecture.Take additional notes on the slides in lecture. Dont take notes too seriously, Just focus on listening and understanding

7、.Dont hesitate to ask questions. Be sure to contact me by sending your feedback to or call me at 83596820 whenever you get any trouble studying BiochemistryDont wait until the day before the exam to cram. I urge you and encourage you:Be sure to contact me by sending your feedback to whenever you get

8、 any trouble studying BiochemistryTextbooks生物化学原理（高等教育出版社杨荣武主编）Principles of Biochemistry.生物化学学习指南与习题解析 （高等教育出版社杨荣武主编）Study guide and Problem solving for Biochemistry.Some English textbooks are also mended: (1) LehningerPrinciples of Biochemistry (2) StryerBiochemistry (3) MathewsBiochemistry (4) Vo

9、etFundamentals of Biochemistry Some mended websites / Molecule of the year1989 PCR and DNA polymerase1990 the manufacture of synthetic diamonds1991 buckminsterfullerene1992 nitric oxide1993 p531994 DNA repair enzyme1995 BoseEinstein condensateBreakthrough of the year 1996 understanding HIV1997 Dolly

10、 the sheep, the first mammal to be cloned from adult cells1998 the accelerating universe, dark matter1999 capturing the promise of youth with stem cells2000 Full genome sequencing2001 nanocircuits or molecular circuit2002 small RNAs2003 dark energy2004 Spirit rover landed on Mars2005 evolution in ac

11、tion2006 proof of the Poincar conjecture2007 Human genetic variation2008 Cellular reprogramming2009 Ardipithecus ramidus2010 The first quantum machine2011 the HPTN 052 clinical trial, an international HIV prevention trial 2012 Nobel Prize in Physiology or Medicine The prize was awarded jointly to: J

12、ohn B. Gurdon And Shinya Yamanaka for the discovery that mature cells can be reprogrammed to e pluripotent2012 Nobel Prize in ChemistryThe prize was awarded jointly to: Robert J. Lefkowitz and Brian K. Kobilka for studies of G-protein-coupled receptorsThe Top two Scientific Achievements of 2010Craig

13、 Venter & SynthiaFelisa Wolfe-Simon & GFAJ-1Who is Craig Venter？Creation of SynthiaWho is Felisa Wolfe-Simon？Mono LakeGFAJ-1 Introduction to BiochemistryWhat is Biochemistry about? Bio + Chemistry = BiochemistryThe Goals of Biochemistry Describe structure, organization, function of cells in molecula

14、r terms (1) Structural biochemistry (2) Metabolic biochemistry (3) Molecular biologyThe Roots of BiochemistryThe Uses of Biochemistry Some Milestones in the Development of BiochemistryWohlers synthesis of urea：“I must tell you that I can prepare urea without requiring a kidney or an animal”Buchners

15、fermentation of sugar from yeast extractsSumners crystallization of ureaseFlemmings discovery of chromosomesMendels characterization of genesMieschers isolation of nucleic acidsWatson and Cricks structure of DNA Genomics and proteomicsThe Uses of BiochemistryAgriculture-GM foodMedicine-Gene TherapyNutrition-Anti-obesityClinical Chemistry-Biochemical Diagnosis vita 2005.pdf；tdy_curry_fibrosis_030617.asfPharmacology-AZT and ViagraToxicology-RicinListen carefully and tell me what it is aboutKey words: cystic fibrosis (囊性纤维变性) glutathione(谷胱甘肽)