BCI-E-BCI-DataSheet-生命科学试剂-MedChemExpresss

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBCICat. No.: HY-115502CAS No.: 1245792-51-1Synonyms: (E)-BCI分式: CHNO分量: 317.42作靶点: Phosphatase作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 125 mg/mL (393.80

2、 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.1504 mL 15.7520 mL 31.5040 mL5 mM 0.6301 mL 3.1504 mL 6.3008 mL10 mM 0.3150 mL 1.5752 mL 3.1504 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄的储备

3、液可以根据储存条件，适当保存；以下溶剂前的百分指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (6.55 mM); Suspended solution; Need ultrasonic2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (6.55 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBI

4、OLOGICAL ACTIVITY物活性 BCI种双重 特异性磷酸酶 (DUSP) 的变构抑制剂。BCI 特异性抑制 DUSP6 和 DUSP1 的 EC50 分别为 13.3 和8.0 M。BCI 不抑制 DUSP5 1。REFERENCES1. Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase.Chembiochem. 2014 Jul 7;15(10):1436-45.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: