BMS-1001-hydrochloride-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBMS-1001 hydrochlorideCat. No.: HY-120635CAS No.: 2113650-04-5分式: CHClNO分量: 631.11作靶点: PD-1/PD-L1作通路: Immunology/Inflammation储存式: Please store the product under the recommended conditions inthe COA.溶解性数据体外实验 DMSO : 12.5 mg/mL (1

2、9.81 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.5845 mL 7.9225 mL 15.8451 mL5 mM 0.3169 mL 1.5845 mL 3.1690 mL10 mM 0.1585 mL 0.7923 mL 1.5845 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄

3、的储备液可以根据储存条件，适当保存；以下溶剂前的百分指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 1.25 mg/mL (1.98 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 1.25 mg/mL (1.98 mM); Clear solutionBIOLOGICAL ACTIVITY物活性BMS-1001 hydrochloride具有服活性的、 PD-

4、L1/PD-1 免疫检查点的抑制剂。BMS-10011/2 Master of Small Molecules 您边的抑制剂师www.MedChemEhydrochloride 具有细胞毒性低的特点。IC50 & Target PD-L1/PD-1 1.体外研究 BMS-1001 binds to human PD-L1 and blocks its interaction with PD-1. BMS-1001 presents low toxicitytowards tested cell lines and block the interaction of soluble PD-L1 w

5、ith the cell surface-expressed PD-1.BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes 1.REFERENCES1. Skalniak L, et al. Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells.Oncotarget. 2017 Aug 7;8(42):72167-72181.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 0