TTP-8307-DataSheet-生命科学试剂-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemETTP-8307Cat.No.:HY-124806CASNo.:950225-08-8分⼦式:C₂₇H₂₁FN₄O分⼦量:436.48作⽤靶点:Enterovirus;DNA/RNASynthesis;HCV作⽤通路:Anti-infection;CellCycle/DNADamage储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCOA.溶解性数据体外实验DMSO:100mg/mL(229.11mM;Needultrasonic)H2O:<0.1mg/mL(insoluble)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.2911mL11.4553mL22.9106mL5mM0.4582mL2.2911mL4.5821mL10mM0.2291mL1.1455mL2.2911mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的⼯作液，建议您现⽤现配，当天使⽤；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分⽐指该溶剂在您配制终溶液中的体积占⽐)：1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:2.5mg/mL(5.73mM);Suspendedsolution;Needultrasonic2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:2.5mg/mL(5.73mM);Suspendedsolution;Needultrasonic3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(5.73mM);Clearsolution1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性TTP-8307⼏种⿐和肠道病毒(rhino-/enteroviruses)复制的有效抑制剂。TTP-8307通过⼲扰病毒RNA的合成抑制coxsackievirusB3病毒(CVB3;EC50=1.2μM)和poliovirus病毒。TTP-8307通过氧化甾醇结合蛋⽩(OSBP)发挥抗病毒活性。体外研究TTP-8307targetsthenonstructuralprotein3A,inhibitsthereplicationofcoxsackievirusB3(CVB3Nancy)withEC50of1.2μM.TTP-8307inhibitsthereplicationofcoxsackievirusB3andthethreepoliovirusSabinstrains,aswellascoxsackievirusesA16andA21(EC50of0.85and5.34μM).TTP-8307inhibitshumanrhinoviruses(HRVs)2,29,39,45,63,and85.Mutationsinthenonstructuralprotein3AconferresistancetothenovelenterovirusreplicationinhibitorTTP-8307[1].TTP-8307inhibitsOSBP-dependentvirusesencephalomyocarditisvirus(EMCV)andHCV[2].REFERENCES[1].DePalmaAM,etal.Mutationsinthenonstructuralprotein3AconferresistancetothenovelenterovirusreplicationinhibitorTTP-8307.AntimicrobAgentsChemother.2009May;53(5):1850-7.[2].AlbulescuL,etal.Uncoveringoxysterol-bindingprotein(OSBP)asatargetoftheanti-enteroviralcompoundTTP-8307.AntiviralRes.2017Apr;140:37-44.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearch