原发性肝癌的化疗现状及进展课件

WelcomWelcom1原发性肝癌的化疗现状及进展皖南医学院弋矶山医院吉兆宁原发性肝癌的化疗现状及进展2流行病学近二十年来,不管是在发达国家(如美国)还是发展中国家或贫穷落后国家,原发性肝癌的发病率和病死率均呈上升趋势。ThomasMB,etal.HepatocellularCarcinoma:T/NeedsforProgress.JClinOncol,2019,23:2892-9流行病学3肝癌常见四大相关因素炎病毒感染,尤其是乙型肝炎病毒。生活污水的不合理处置和饮用水的污染。你用水源一且被污染,可以进一步加重伴有肝炎背景患者的病情,促进肝癌形成饮用烈性酒和酗酒,往往加重了原有的肝脏疾病。°黄曲霉毒素。肝癌常见四大相关因素4在我国,尽管采取了“改水、防霉、防肝炎”等一系列预防措施,但多年来肝癌的发病率和病死率仍未见明显回落。全球每年新增肝癌病例约63万例,其中55%发生在我国。ParkinDM,etal.Globalcancerstatistics,2019.CCancerclin.2019:55:74-108在我国,尽管采取了“改水、防霉、防5中国为原发性肝癌高发地区2019年全球新发病例Sauth-CsstemAnla中国病例占55%,约344,000男性高发于女性(2.67AgestandardizedincidenceperGlobalCancerStatistics.2019.CACancerJC/in2019:55:74-108中国为原发性肝癌高发地区6原发性肝癌治疗难点大多合并严重肝硬化易发生肝内播散和远处转移术后复发率高°约20%患者可获手术治疗原发性肝癌治疗难点7肝痘规苑治疗关键因素肿瘤大小和数目胂瘤累及部位和范围静脉癌栓与远处转移肝功能代偿程度及全身状况肝痘规苑治疗关键因素8原发性肝癌的治疗模式原发性肝癌的治疗模式9肝癌的治疗模式及效果TreatmentOptionCommentsLivertransplantation5-yearsurvivalratesBefore2019:20%-36%Improvement2019-2019:61.1%0SurgicalresectionHistorical5-yearsurvivalrates30%o-40%0Recent5-vearPSwas480TACEImprovementin1-yearsurvivalfrom32%0(supportivecarecontrols)to57%oforTACEintientswithtumors<7cm,preservedliverfunctionandPsoThomasMB,etal.HepatocellularCarcinoma:TheNeeforProgress.ClinOncol,2019,23:2892-9肝癌的治疗模式及效果10原发性肝癌的化疗现状及进展课件11原发性肝癌的化疗现状及进展课件12原发性肝癌的化疗现状及进展课件13原发性肝癌的化疗现状及进展课件14原发性肝癌的化疗现状及进展课件15原发性肝癌的化疗现状及进展课件16原发性肝癌的化疗现状及进展课件17原发性肝癌的化疗现状及进展课件18原发性肝癌的化疗现状及进展课件19原发性肝癌的化疗现状及进展课件20原发性肝癌的化疗现状及进展课件21原发性肝癌的化疗现状及进展课件22原发性肝癌的化疗现状及进展课件23原发性肝癌的化疗现状及进展课件24原发性肝癌的化疗现状及进展课件25原发性肝癌的化疗现状及进展课件26原发性肝癌的化疗现状及进展课件27原发性肝癌的化疗现状及进展课件28原发性肝癌的化疗现状及进展课件29原发性肝癌的化疗现状及进展课件30原发性肝癌的化疗现状及进展课件31原发性肝癌的化疗现状及进展课件32原发性肝癌的化疗现状及进展课件33原发性肝癌的化疗现状及进展课件34原发性肝癌的化疗现状及进展课件35原发性肝癌的化疗现状及进展课件36原发性肝癌的化疗现状及进展课件37原发性肝癌的化疗现状及进展课件38原发性肝癌的化疗现状及进展课件39原发性肝癌的化疗现状及进展课件40原发性肝癌的化疗现状及进展课件41原发性肝癌的化疗现状及进展课件42原发性肝癌的化疗现状及进展课件43原发性肝癌的化疗现状及进展课件44原发性肝癌的化疗现状及进展课件45原发性肝癌的化疗现状及进展课件46原发性肝癌的化疗现状及进展课件47原发性肝癌的化疗现状及进展课件48原发性肝癌的化疗现状及进展课件49原发性肝癌的化疗现状及进展课件50原发性肝癌的化疗现状及进展课件51WelcomWelcom52原发性肝癌的化疗现状及进展皖南医学院弋矶山医院吉兆宁原发性肝癌的化疗现状及进展53流行病学近二十年来,不管是在发达国家(如美国)还是发展中国家或贫穷落后国家,原发性肝癌的发病率和病死率均呈上升趋势。ThomasMB,etal.HepatocellularCarcinoma:T/NeedsforProgress.JClinOncol,2019,23:2892-9流行病学54肝癌常见四大相关因素炎病毒感染,尤其是乙型肝炎病毒。生活污水的不合理处置和饮用水的污染。你用水源一且被污染,可以进一步加重伴有肝炎背景患者的病情,促进肝癌形成饮用烈性酒和酗酒,往往加重了原有的肝脏疾病。°黄曲霉毒素。肝癌常见四大相关因素55在我国,尽管采取了“改水、防霉、防肝炎”等一系列预防措施,但多年来肝癌的发病率和病死率仍未见明显回落。全球每年新增肝癌病例约63万例,其中55%发生在我国。ParkinDM,etal.Globalcancerstatistics,2019.CCancerclin.2019:55:74-108在我国,尽管采取了“改水、防霉、防56中国为原发性肝癌高发地区2019年全球新发病例Sauth-CsstemAnla中国病例占55%,约344,000男性高发于女性(2.67AgestandardizedincidenceperGlobalCancerStatistics.2019.CACancerJC/in2019:55:74-108中国为原发性肝癌高发地区57原发性肝癌治疗难点大多合并严重肝硬化易发生肝内播散和远处转移术后复发率高°约20%患者可获手术治疗原发性肝癌治疗难点58肝痘规苑治疗关键因素肿瘤大小和数目胂瘤累及部位和范围静脉癌栓与远处转移肝功能代偿程度及全身状况肝痘规苑治疗关键因素59原发性肝癌的治疗模式原发性肝癌的治疗模式60肝癌的治疗模式及效果TreatmentOptionCommentsLivertransplantation5-yearsurvivalratesBefore2019:20%-36%Improvement2019-2019:61.1%0SurgicalresectionHistorical5-yearsurvivalrates30%o-40%0Recent5-vearPSwas480TACEImprovementin1-yearsurvivalfrom32%0(supportivecarecontrols)to57%oforTACEintientswithtumors<7cm,preservedliverfunctionandPsoThomasMB,etal.HepatocellularCarcinoma:TheNeeforProgress.ClinOncol,2019,23:2892-9肝癌的治疗模式及效果61原发性肝癌的化疗现状及进展课件62原发性肝癌的化疗现状及进展课件63原发性肝癌的化疗现状及进展课件64原发性肝癌的化疗现状及进展课件65原发性肝癌的化疗现状及进展课件66原发性肝癌的化疗现状及进展课件67原发性肝癌的化疗现状及进展课件68原发性肝癌的化疗现状及进展课件69原发性肝癌的化疗现状及进展课件70原发性肝癌的化疗现状及进展课件71原发性肝癌的化疗现状及进展课件72原发性肝癌的化疗现状及进展课件73原发性肝癌的化疗现状及进展课件74原发性肝癌的化疗现状及进展课件75原发性肝癌的化疗现状及进展课件76原发性肝癌的化疗现状及进展课件77原发性肝癌的化疗现状及进展课件78原发性肝癌的化疗现状及进展课件79原发性肝癌的化疗现状及进展课件80原发性肝癌的化疗现状及进展课件81原发性肝癌的化疗现状及进展课件82原发性肝癌的化疗现状及进展课件83原发性肝癌的化疗现状及进展课件84原发性肝癌的化疗现状及进展课件85原发性肝癌的化疗现状及进展课件86原发性肝癌的化疗现状及进展课件87原发性肝癌的化疗现状及进展课件88原发性肝癌的化疗现状及进展课件89原发性肝癌的化疗现状及进展课件90原发性肝癌的化疗现状及进展课件9