MC-VA-PABC-MMAE-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEMC-VA-PABC-MMAECat.No.:HY-147239CASNo.:1818864-51-5分⼦式:C₆₅H₉₉N₉O₁₄分⼦量:1230.53作⽤靶点:Drug-LinkerConjugatesforADC作⽤通路:Antibody-drugConjugate/ADCRelated储存⽅式:-20°C,sealedstorage,awayfrommoistureandlight*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoistureandlight)溶解性数据体外实验DMSO:100mg/mL(81.27mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM0.8127mL4.0633mL8.1266mL5mM0.1625mL0.8127mL1.6253mL10mM0.0813mL0.4063mL0.8127mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoistureandlight)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(2.03mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(2.03mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性MC-VA-PABC-MMAE抗体偶联药物ADC的⼀部分。MC-VA-PABC-MMAE由ADClinker(peptideMC-VA-PABC)和强效微管蛋⽩聚合抑制剂MMAE(HY-15162)偶联⽽成。IC50&TargetAuristatin体外研究ADCsarecomprisedofanantibodytowhichisattachedanADCcytotoxinthroughanADClinker[1].REFERENCES[1].WangY,etal.Developmentofapplicablethiol-linkedantibody-drugconjugateswithimprovedstabilityandtherapeuticindex.DrugDeliv.2022Dec;29(1):754-766.[2].CazzamalliS,etal.Linkerstabilityinfluencestheanti-tumoractivityofacetazolamide-drugconjugatesforthetherapyofrenalcellcarcinoma.JControlRelease.2017Jan28;246:39-45.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-