耳针治疗围绝经期综合征随机对照研究

耳针治疗围绝经期综合征随机对照研究

1clnic生产力1.1ines:1.4.4细内格氏家族的pms模式是一种改进的机制。（1）40-60；（2）具有讽刺意味的人，他们是热狗、腹泻、西泮、帕斯米、可卡因、母皮屑和睡眠、改善或损害、承认、承认或承认；（3）最终证据模型（e3）、fsh、fsh和琅琊（lh）。1.2内皮细胞1.3内插入式扩张力1.4关于dense的研究1.5一般数据1.6measuningraftsTheSPSS13.0softwarewasadoptedfordataanalyses.Themeasurementdatawereexpressedby;theage,diseasedurationandKMIwerecomparedbyusingt-test,andtheclinicaleffectbyusingRidittest.2死亡随机对照试验2.1亚拉斯科学组2.2控制小组3内皮拉斯3.1kmiratioFilltheKMIformsbeforethetreatmentstartedandduringtherevisitafterthefinaltreatment.ItwasevaluatedbytheimprovedKMI.TheKMIscorewastheaggregatescoreofthesub-items,andthecriteriaoftherapeuticeffectswerebasedontheKMIratio.KMIratio=KMIofaftertreatment/KMIofbeforetreatment×100%.Markedeffect:KMIratio<25%.Allofthesubjectswereevaluatedafter10-daytreatments.Afollow-upstudywouldbeconducted3monthsafterthefinaltreatment.3.2产品系统3.2.1改变sofkmi3.2.2内插4an网络an网络an坚持的sqp.4.3.4.3日国际女性,参与整理剂.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.5.4.3.3.3.3.3.3.3.3.3.3.3.3.4.5.4.5.4.3.3.3.3.3.3.3.3.3.4.3.4和5.4.5.3.3.3.3.3.4.3.3.3.3.3.3.4.3.4.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.4和5.4.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.3.Perimenopausesyndrome(PMS),orclimactericsyndrome,iscausedbyunsteadyordecliningestrogenlevelsinfemalesagedbetween45-55yearsold,manifestedbyfunctionaldisturbanceoftheautonomicnervoussystem,coupledwithneuropsychologicalsymptoms.AccordingtotheWHO,perimenopauseisusedinsteadofclimacteric,referringtothephasebeforemenopause,whenmenopauserelatedendocrine,biologicalandclinicalsymptomsappear,untilayearafterpermanentmenopause.ThisstudytreatedPMSwithelectroacpunctureatauricularpoints,andcompareditsclinicaleffectwithGengNianAn(MenopauseHelper)tablets.Itisnowsummarizedasfollows.AccordingtotheModernGynecology,premenopausereferstothephasebeforemenopausebegins,whenitpresentsirregularperiodsanddecliningovaryfunction.Post-menopausereferstothephaseaftermenopause,normallycountingfromayearaftermenopausetothecompletelossofovulation.(1)Conformedtotheabovediagnosticcriteria,anddiagnosedwithPMS;(2)signedtheinformedconsentform,andadheredtotreatment,andrevisitedintime.(1)Patientswhotooksleeppillsforalongterm.(2)Patientswhotookhormoneoranyotherdrugsintherecent3monthsthatmayinfluencetheendocrinesystem.(3)Patientswhohadhyperthyroidism,neurosis,psychologicaldisease,orseveredermalogicaldisease,orcoagulationdisorder.(4)Patientswhoreceivedotherrelevanttreatmentsbesidestheinterventionadoptedinthisstudy.Threeclinicalstudycentersweredevelopedandeverycenterselectedthesubjectsrigorouslyaccordingtothediagnostic,inclusionandexclusioncriteria.Intotalof276subjectswithPMSwereenrolled,and21dropped,withthedropratecontrolled<15%.Basedongradation,randomizedandblindmethods,thepre-menopausalandpostmenopausalpatientsweredistributedintoanearacupuncturegroupandacontrolgroup.Theenrolled276patientswerefromHangzhouHospitalofRedCrossCommittee,ZhejiangProvincialHospitalofTraditionalChineseMedicine,andHonghuiHospitalofXiachengDistrictofHangzhou.Theywererandomizedintoanearacupuncturegroupandacontrolgroupaccordingtotheirvisitingorder.Therewerenosignificantdifferencesinage,diseasedurationandKuppermanMenopausalIndex(KMI)betweenthetwogroups(P>0.05),indicatingacomparability(table1).Therewere276casesenrolledintotal,butonly255remainedand21dropped,withadroprateof7.6%.Therewere62casesofpre-menopauseand63casesofpost-menopauseintheearacupuncturegroup;therewere64casesofpre-menopausaland66casesofpost-menopauseinthecontrol.Acupoints:BilateralEndocrine(CO18),InternalGenitals(TF2),Sympathetic(AH6a),andEarShenmen(TF4).Afterstandardsterilizationwithiodine,filiformneedlesof0.22mmindiameterand25mminlengthwerepuncturedperpendicularlyintothesensitivepointoftheacupointzonebydepthof2-3mm.Thebodyoftheneedleshouldstaystable.Aftertheneedlingsensationarrival,thehandlesoftheneedleswereconnectedtoHan’sAcupointNerveStimulator,withtheipsilateralEndocrine(CO18),InternalGenitals(TF2)connectedtoapairofelectrodes,withcontinuouswave,intensityof2mA,frequencyof15Hz,for30min.Afterremovaloftheneedles,presstheneedleholeswithsterilizedcottonswabfor0.5min.Thetreatmentwasgivenonceaday,forsuccessive10dintotal.TakeGengNianAn(MenopauseHelper)tablets,producedbyLeRenTang,Tianjin)orally,threetimesaday,6tabletseachtime,forsuccessive10dintotal.Effective:25%≤KMIratio≥80%.Invalid:KMIratio>80%.AsignificantdecreaseofKMIwasrevealedbothinpre-menopausalandpost-menopausalpatients(P<0.01)comparedwithpre-treatment.Althoughitwasfoundmarkedlyincreasedduringthefollow-upvisit(P<0.05orP<0.01),itwassignificantlylowercomparedwithpre-treatment(P<0.05orP<0.01).ItindicatedthatbothearacupunctureandGengNianAn(MenopauseHelper)tabletscanhelpimprovethesymptomsofPMS(table2).Thetotaleffectiverateofpre-menopauseintheearacupuncturegroupwas96.8%,versus56.3%inthecontrol;andthatofpost-menopausewas85.7%intheearacupuncturegroup,versus53.0%inthecontrol.Itshowedthatthetherapeuticeffectwassignificantlybetterintheearacupuncturegroup(P<0.01)(table3).PMSisasymptomcomplexofautonomicnervousdysfunctioninwomenaroundmenopausephasecausedbydecliningovaryfunctionandestrogenlevelmajorlymanifestedbyirregularmenstruation,hotflushes,sweating,insomnia,memoryproblem,irritability,depression,aswellaspalpitations,chestsuppression,fatigue,andmuscularflaccidity.ItbelongstothescopeofsymptomsaroundmenopauseintraditionalChinesemedicine(TCM).TheTCMtheoryholdsthattheradicalcauseshouldbedeficiencyofkidneyessence,impairedThoroughfareandConceptionVessels,followedbyimbalancebetweenyinandyanginfiveZangorgans.Thatistosaythekidneydeficiencyistheoriginalcause,andtheheart-liverfireisthesuperficialmanifestation.Therefore,thetreatmentshouldbefocusedontonifyingkidney,withregulatingfiveZangorgansastheaccessory.Astheexternalorificeofkidney,earisthejointofallvessels,andrelatedcloselywithZang-fuorgans,meridiansandcollaterals.Modernresearcheshavereportedthateachorganofthebodycanfinditscorrespondingpointontheauricle,andthedistributionofauricularpointsisimagedasaninvertedfetus.Therefore,bystudyingtheear,wecanknowtheconditionofZang-fuorgansaswellasmeridiansandcollaterals.Throughstimulatingtheauricularpoints,wecanregulatethefunctionofZang-fuorgans,meridiansandcollaterals,restoreitsbalance,andtreattherelevantdiseases.Auricularpointsarecloselyrelatedtomultipleorgansandmeridians,andthereforegoodattreatingthediseasescausedbydysfunctionofmultipleorgans,andgenerallymodulatingthefunctionofthebody.Basedontheaboveknowledgeofauricularpoint,thepresentstudyadoptedearacupuncturefortreatingPMS,whichiscausedbydysfunctionofmultipleorgans,andtoobtainclinicalevidencetoprovethetheory.ThestudyshowedthatearacupuncturesignificantlyreducedKMIscore.Althoughitwasincreased(P<0.05orP<0.01)inthefollow-upstudy,theKMIscorewasmarkedlylowercomparedwiththepre-treatment(P<0.05orP<0.01).ItsuggestedthatearacupuncturecouldeffectivelyimprovethesymptomsofPMS.Earacupuncturewaseffectiveforbothpre-menopausalandpost-menopausalpatients,anditseffectwasbetterthanGengNianAn(MenopauseHelper)tablets,whichwasdecidedbytheresultoftheprevioussmallsizedclinicalstudy.Residentontheauricle,theauricularpointsEndocrine(CO18),InternalGenitals(TF2),Sympathetic(AH6a),andEarShenmen(TF4)arecloselyassociatedwiththenervousandendocrinesystems.Bystimulatingtheabovepoints,electro-acupuncturecanregulatethenervousandendocrinef