药学专业外语丹参

丹参RadixSalviaeMiltiorrhizaeMainContentsOriginsPlantMorphologyCollectionandPreparationProductionandCommerceDescriptionMicroscopicalCharactersChemicalConstituentsPhysicalandChemicalIdentificationHighPerformanceLiquidChromatography2编辑pptPlantMorphology

Aperennialherb,denselypubescentandglandularhairythroughout.Rootcylindrical,vermillion.Stem4-angled,branchedattheupperpart.Leavesopposite,pinnatelycompound;leaflets5～7,ovateorelliptical-ovate,serratealongthemargin,pubescentonbothsurfaces.vermillion：朱红色serrate：锯齿状的3编辑ppt

Flowersinterminaloraxillaryverticillatepseudo-racemes;calyxbell-shaped;corollabluish-purple.Theupperliperect,slightlyfalcate,retuseatapex,thelowershorter,3-lobed,themiddlelobelarger,2-cleft;stamens2,filamentsshort,connectiveslong,theupperendoftheconnectivebearingafertileanther-cell,thelowerendwithanimperfectone;ovarydeeply4-lobed,stylegynobasic.Nutlets4,ellipsoid.verticillate：轮生

angled：棱pseudo-：假的retuse:浅凹形falcate:钩状的filament:花丝style：花柱anther：花粉囊

gynobasic:着生于基部的4编辑pptDescription

Rootcylindricalorconical,usuallycurved,branched,10～30cmlong,0.3～1.5cmindiameter.Externallybrick-red,brownish-redorpurplish-brown,rough,longitudinallyfurrowedorwrinkled,thebarkofoldrootsmostlyscalingoff,sometimescrownedwithremainsofstembase.conical:圆锥形的

5编辑ppt

Texturehardandfragile,fracturefibrous,barkdarkreddish-browntopurplish-brown,woodshowingbundlesofvessels,yellowish-white,arrangedradially.Odour,slight;tasteslightlyastringent.fragile:脆的astringent:收敛性的6编辑pptTransversesection

Corkconsistingofseverallayersofcells,mostlycontainingorangeorpurplish-browncontents.Phellodermnarrow.Phloemrelativelybroad.Cambiumringdistinct.Xylembundlesradial,consistingofvessels,xylemfibresandxylemparenchyma.Xylemfibresoftenaccompaniedbyvessels.Stonecellsscatteredinphellodermandphloem.cortex:栓皮，皮层phelloderm:栓内层7编辑ppt

Reddish-brown.Stonecellsoccurringsinglyandscatteredthroughout,subrounded,subrectangular,subfusiformorirregular,upto257μmlong,20～65μmindiameter,someofthemcontainingbrowncontents.Reticulatedandborderedpittedvessels,andbundlesofxylemfibresfrequent.Corkcellsyellowish-brown,subsquareorpolygonalinsurfaceview,containingreddish-brownpigments,dissolvedonmountinginchloralhydratesolution.Powdersurfaceview:外表观mount:做标本chloralhydrate:水合氯醛8编辑pptTanshinoneⅠ,tanshinoneⅡA,tashinoneⅡB,cryptotanshinone,dihydroisotanshinoneⅠ,hydroxytanshinone,isotanshinoneⅠ,Ⅱ,iso-cryptotanshinone,miltirone,salviol,etc.【化学成分】

丹参酮Ⅰ，丹参酮ⅡA，丹参酮ⅡB，隐丹参酮，二氢丹参酮Ⅰ，羟基丹参酮，异丹参酮Ⅰ、Ⅱ，异隐丹参酮，丹参新酮，鼠尾草酚等。ChemicalConstituents9编辑ppttanshinoneⅡA

丹参酮ⅡAsalvianolicacidB丹酚酸B10编辑ppt〔1〕Boil5gofthepowderin50mlofwaterfor15～20minutes,coolandfilter.Concentratethefiltrateonawaterbath,dissolvetheextractin3～5mlofethanol,filter.Applyseveraldropsofthefiltratetoapieceoffilterpaper,allowittodryandexamineunderultra-violetlight(365nm),abrightbluish-greyfluorescenceisproduced.Exposethefilterpapertoammoniavapourfor20minutes,removethefilterpaperandexamineagainunderultra-violetlight(365nm),apalebluish-greenfluorescenceisproduced.PhysicalandchemicalIdentification11编辑ppt【理化鉴别】

〔1〕置5g粉末于50ml水中煎煮15~20分钟，冷却后过滤.在水浴中浓缩滤液，用3~5ml乙醇溶解浓缩产物，过滤。将滤液在滤纸上点一些斑点，斑点挥干后在365nm波长紫外光下观察，可看到明亮的蓝灰色荧光。将滤纸置于氨气中20分钟后，在365nm波长紫外光下观察，可见淡蓝绿色荧光。12编辑ppt〔2〕To0.5mlofthefiltrateobtainedfromIdentification(1),add1～2dropsofferricchlorideTS:adullgreencolorisproduced.ferricchloride:

三氯化铁TS：testsolutiondull:暗的〔2〕从〔1〕的滤液中移取0.5ml，加1~2滴三氯化铁试液：可见滤液变为暗绿色。13编辑ppt(3)To1gofthepowderadd5mlofether,shakeinastopperedtesttubeandstandfor1hourandfilter.Evaporatethefiltratetodryness.Dissolvetheresiduein1mlofethylacetateasthetestsolution.PrepareasolutionofRadixSalviaeMiltiorrhizaereferencedruginthesamemanner,usedasthereferencedrugsolution.DissolveTanshinoneⅡACRSinethylacetatetoproduceasolutionof2mgpermlasthereferencesolution.astopperedtesttube:具塞试管standfor：静置residue:残渣referencedrug:对照药材CRS：ChemicalReferenceStandard14编辑ppt〔3〕取1g粉末加5ml石油醚于有塞试管中振摇，静置1小时后过滤。将滤液蒸干。残渣用1ml乙酸乙酯溶解后作为供试品溶液。用同样方法制备丹参对照药材的溶液，作为对照药材溶液。将丹参酮ⅡACRS溶解在乙酸乙酯中制成每ml中含2g丹参酮ⅡA溶液，作为对照品溶液。15编辑ppt

Carryoutthemethodforthinlayerchromatography,usingsilicagelGasthecoatingsubstanceandbenzene-ethylacetate

(19:1)asthemobilephase.Applyseparatelytotheplate5μlofeachofthethreesolutions.Afterdevelopingandremovaloftheplate,dryitinair.

16编辑ppt

Thespotsinthechromatogramobtainedwiththetestsolutioncorrespondinpositionandcolourtothespotsinthechromatogramobtainedwiththereferencedrugsolution;andthedark-redspotinthechromatogramobtainedwiththetestsolutioncorrespondsinpositionandcolourtothespotinthechromatogramobtainedwiththereferencesolution.correspondsto:对应于，与一致17编辑ppt照薄层层析色谱方法，用硅胶G作为固定相，苯-乙酸乙酯〔19：1〕作为展开剂。将3份溶液分别点5μl于同一薄层板上，展开,晾干。供试品溶液的色谱中在与对照药材溶液色谱的相应位置上有相同斑点；并且供试品溶液色谱中在与对照品溶液色谱相应位置上有相同的深红色斑点。18编辑pptPharmacology(1)Coronaryartery-dilatingeffect:Itcanincreasebloodflowbydilatingcoronaryarteries.(2)Sedativeeffect(3)Antibacterialandantifungaleffects:ItstronglyinhibitsStaphylococcusaureus,andhasadefiniteinhibitoryactiononMycobacteriumtuberculosisandsomedermatophytes.【药理作用】〔1〕扩张冠状动脉作用：通过扩张冠状动脉可增加血流量。〔2〕镇静作用〔3〕抗菌、抗真菌作用：能强烈抑制金黄色葡萄球菌，并能明显抑制肺结核杆菌和一些皮肤真菌。19编辑pptActionTopromotebloodcirculationandstimulatemenstrualdischarge,toremovebloodstasisandrelievepain,andtonourishtheheartandtranquilizethemild.【成效】活血调经，祛瘀止痛，养心安神20编辑pptIndicationMenstr