Mer-c-Met-IN-1-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEMer/c-Met-IN-1Cat.No.:HY-178438CASNo.:3062159-91-2分子式:C₃₈H₃₈FN₇O₄分子量:675.75作用靶点:c-Met/HGFR;Apoptosis作用通路:ProteinTyrosineKinase/RTK;Apoptosis储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Mer/c-Met-IN-1是一种强效的Mer/c-met双抑制剂，其IC50值分别为1nM和19nM。Mer/c-Met-IN-1能够抑制癌细胞的增殖、迁移并诱导凋亡(apoptosis)。Mer/c-Met-IN-1可用于癌症研究，如结肠癌[1]。体外研究Mer/c-Met-IN-1exhibitsrobustantiproliferativeactivityagainstHCT116,A2780,andPC-3cancercelllineswithIC50valuesof1.01μM,0.96μM,and3.42μMrespectively[1].Mer/c-Met-IN-1showsfavorablemetabolicstabilityinhumanlivermicrosomeswithahalf-life(t1/2)of72.6minandaclearancerate(CL)of0.05mL/min/mg[1].Mer/c-Met-IN-1exhibitsnegligibleinhibitiononhERGpotassiumchannelswithanIC50value>40μM[1].Mer/c-Met-IN-1(0.4-3.2μM,48h)inducesdose-dependentapoptosisinHCT116cellswithanED50of1.368pM[1].Mer/c-Met-IN-1(0.8-20μM,24h)significantlysuppressesthemigrationofHCT116cells[1].ApoptosisAnalysis[1]CellLine:HCT116cellsConcentration:0.4,0.8,1.6and3.2μMIncubationTime:48hResult:IncreasedtheTunel-positivecells.REFERENCES1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEDuanL,etal.Design,synthesis,andbiologicalevaluationofnovelpotentdualMer/c-Metinhibitorsbasedonstructuraloptimization.BioorgMedChemLett.2025Sep20;130:130415.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>