CN119732855A 脱羧肌肽衍生物及其制备方法和应用

(12)发明专利申请(10)申请公布号CN119732855A(21)申请号202510250311.1(22)申请日2025.03.04(57)摘要时些量时些量234567附图说明89CN119732855A说明书5/14页[0050]H-NMR(500MHz,CD₃OD):87.59(s,1H),6.85(s(t,2H),2.38-2.34(t,2H),2.16-2.13(t,2H),1.59-1.57(m,2H),1.32-1.2(t,2H),2.38-2.34(t,2H),2.16-2.13(t,2H),1.59-1.57(m,2H),1.32-1.21(m,12H),0.[0056]H-NMR(500MHz,CD₃OD):87.59(s,1H),6.85(s,1H),(t,2H),2.38-2.34(t,2H),2.16-2.13(t,2H),1.59-1.57(m,2H),1.32-1.21(m,16H),0.(t,2H),2.38-2.34(t,2H),2.16-2.13(t,2H),1.59-1.57(m,2H),1.32-1.21(m,20H),0.[0062]H-NMR(500MHz,CD₃OD):87.59(s,1H),6.85(s,1H),(t,2H),2.38-2.34(t,2H),2.16-2.13(t,2H),1.59-1.57(m,2H),1.32-1.21(m,24H),0.[0065]H-NMR(500MHz,CD₃OD):87.59(s,1H),6.85(s,1H),(m,4H),2.78-2.74(t,2H),2.38-2.34(t,2H),2.16-2.13(t,2H),1.80-1.85(m,4H),1.[0068]H-NMR(500MHz,CD₃OD):87.59(s,1H),6.85(s,1H),3(t,2H),2.38-2.34(m,3H),1.61-1.57(m,4H),1.32-1.21(m,20H),0.9[0070]H-NMR(500MHz,CD₃OD):87.59(s,1H),6.85(s,1H),3(t,2H),2.38-2.34(t,2H),2.16-2.13(t,2H),1.59-1.57(m,2H),1.35-1.21(m,4H),0.烷(500mL),降温至0-5℃,加入三乙胺(24.5g,0.22mol)、HOBt(13.5g,0.1mo[0074]H-NMR(500MHz,D₂0):87.59(s,1H),6.85(s,1H),3.43-3.38(m,烷(500mL),降温至0-5℃,加入三乙胺(24.5g,0.22mol)、HOBt(13.5g,0.1mol)和EDCI[0077]H-NMR(500MHz,D₂0):88.61(s,1H),7.30(s,1H),3.532H),3.00-2.97(t,3H),2.67-2.63时间40℃光照实施例1实施例2实施例344实施例4实施例5实施例67实施例8组别偏差对比例1对比例2实施例1实施例2实施例3实施例4实施例5实施例6实施例7实施例8组别DPPH自由基清除率(%)偏差对比例1对比例2实施例1实施例2实施例3实施例4实施例5实施例6实施例7实施例8组别ROS相