Flupirtine-d6-hydrochloride-D-9998-d-sub-6-sub-hydrochloride-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEFlupirtine-d6hydrochlorideCat.No.:HY-W709349SSynonyms:D9998-d6hydrochloride分⼦式:C₁₅H₁₂D₆ClFN₄O₂分⼦量:346.82作⽤靶点:Isotope-LabeledCompounds;PotassiumChannel;iGluR作⽤通路:Others;MembraneTransporter/IonChannel;NeuronalSignaling储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Flupirtine-d6(D9998-d6)hydrochloride氘代标记的Flupirtinehydrochloride(HY-W709349)。Flupirtinehydrochloride(D9998hydrochloride)⼀种选择性的神经钾通道开放剂，具有镇痛活性。Flupirtinehydrochloride被⽤于抑制各种疼痛状态，包括慢性肌⾁⾻骼疼痛、偏头痛和神经痛等。Flupirtinehydrochloride具有抗抑郁和抗氧化的特性，并能增加与吗啡的联合疗法中的镇痛作⽤。Flupirtinehydrochloride能够缓解异常增加的肌⾁紧张，并具有肌⾁松弛作⽤。Flupirtinehydrochloride在临床中相较于其他药物，如曲马多和潘妥昔，再加上副作⽤的耐受性更优。Flupirtinehydrochloride对抑制神经过度兴奋具有显著效果，因此在各种疼痛状态中展现出抑制潜⼒。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].KornhuberJ,etal.FlupirtineshowsfunctionalNMDAreceptorantagonismbyenhancingMg2+blockviaactivationofvoltageindependentpotassiumchannels.Rapidcommunication.JNeuralTransm.1999;106(9-10):857-67.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: