MS102-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEMS102Cat.No.:HY-179630CASNo.:3058587-77-9分⼦式:C₂₄H₁₇BrF₃N₃O₃S₂分⼦量:596.44作⽤靶点:Deubiquitinase;SARS-CoV;VISTA作⽤通路:CellCycle/DNADamage;Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性MS102⼀种⼝服有效的泛素特异性肽酶2(USP2)抑制剂，其IC50为5.46μM。MS102对ACE2依赖性冠状病毒具有有效的抗病毒活性。MS102在体外和体内均能显著降低V结构域免疫球蛋⽩T细胞活化抑制因⼦(VISTA)蛋⽩的丰度。MS102可⽤于SARS-CoV-2的研究。MS102可与抗PD-1免疫⽅法联合使⽤以增强抗肿瘤免疫反应。IC50&TargetUSP25.46μM(IC50)体外研究MS102demonstratesimprovedefficacyinblockingtheinfectionofprimaryhumanbronchialepithelial(NHBE)cellsbytheauthenticSARS-CoV-2wild-type.MS102hasminimalcytotoxicityinHepG2andCalu-3cells[1].MS102iseffectiveininhibitingtheACE2-dependentcoronavirushCoV-NL63(anACE2-dependentcoronavirus)withanEC50of80nM[1].MS102demonstratessignificantreductioninVISTAproteinlevelsinMDA-MB-231,SUM159,MDA-MB-436,EMT6,andRENCAcells[2].体内研究MS102(25mg/kg,i.p.,dailyfor4days,followedby6hourschallengewithSARS-CoV-2WT)reducesSARS-CoV-2viralloadandlungpathologyinK18-hACE2transgenicmice[1].MS102(10mg/kg,intraperitonealdaily,for21dyas)enhancesanti-PD-1immunotherapybyreducingVISTAandpromotingTcellactivityinsyngeneicmousetumormodels[2].AnimalModel:K18-hACE2(transgenicmice,humanACE2drivenbyK18promoter)wereinfectedwith1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESARS-CoV-2OmicronBA.2sublineage[1]Dosage:25mg/kgAdministration:Dailyfor4days,followedby6hchallengewithSARS-CoV-2WTResult:Showedtheenhancedreductioninthe50%tissuecultureinfectiousdose(TCID50)andimprovedlungpathologyinthetreatedmice.Exhibitednotablyenhancedoutcomescomparedwiththecontrolmice.AnimalModel:FemalBALB/c(6-week-old)weresubcutaneouslyinjectedwith1×105MC38cells[2]Dosage:10mg/kgAdministration:Intraperitoneal,daily,for21daysResult:SignificantlyreducedVISTAproteinlevelsintumortissues,enhancedTcellinfiltration,andimprovedanti-PD-1immunotherapyefficacy.Combinationtherapywithanti-PD-1ledtosignificanttumorgrowthinhibition,withsurvivalratescomparabletoVsirKOtumormodels.REFERENCES[1].DangF,etal.USP2inhibitionpreventsinfectionwithACE2-dependentcoronavirusesinvitroandisprotectiveagainstSARS-CoV-2inmice.SciTranslMed.2023;15(725):eadh7668.[2].LiChen,etal.TargeteddestructionofVISTAboostsanti-tumorimmunotherapy.CellRes.2025Dec;35(12):987-1002.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplicati